ragc-1;rde-1

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Genetic mutants with ragc-1, rde-1 alterations

Names of genes are ordered alphabetically. For the order of interventions, please see the specific paper.

Temperature °C
20
Diet
NGM
Lifespan (days)
23.69
Lifespan comparisons
Double mutant ragc-1(RNAi);rde-1(ne219) has a lifespan of 23.69 days, while single mutant rde-1(ne219) has a lifespan of 24.24 days.
Citation
View abstract
Robida-Stubbs S et al., 2012, TOR signaling and rapamycin influence longevity by regulating SKN-1/Nrf and DAF-16/FoxO. Cell Metab. 15(5):713-24 22560223 Click here to select all mutants from this PubMed ID in the graph
Abstract
The TOR kinase, which is present in the functionally distinct complexes TORC1 and TORC2, is essential for growth but associated with disease and aging. Elucidation of how TOR influences life span will identify mechanisms of fundamental importance in aging and TOR functions. Here we show that when TORC1 is inhibited genetically in C. elegans, SKN-1/Nrf, and DAF-16/FoxO activate protective genes, and increase stress resistance and longevity. SKN-1 also upregulates TORC1 pathway gene expression in a feedback loop. Rapamycin triggers a similar protective response in C. elegans and mice, but increases worm life span dependent upon SKN-1 and not DAF-16, apparently by interfering with TORC2 along with TORC1. TORC1, TORC2, and insulin/IGF-1-like signaling regulate SKN-1 activity through different mechanisms. We conclude that modulation of SKN-1/Nrf and DAF-16/FoxO may be generally important in the effects of TOR signaling in vivo and that these transcription factors mediate an opposing relationship between growth signals and longevity.

Temperature °C
20
Diet
NGM
Lifespan (days)
21.39
Lifespan change (compared to wild type)
-0.79%
Lifespan comparisons
Double mutant ragc-1(RNAi);rde-1(ne219) has a lifespan of 21.39 days, while single mutant ragc-1(RNAi) has a lifespan of 28.31 days, single mutant rde-1(ne219) has a lifespan of 23.72 days and wild type has a lifespan of 21.56 days.
Type of interaction
See methods
Antagonistic (negative)
Citation
View abstract
Robida-Stubbs S et al., 2012, TOR signaling and rapamycin influence longevity by regulating SKN-1/Nrf and DAF-16/FoxO. Cell Metab. 15(5):713-24 22560223 Click here to select all mutants from this PubMed ID in the graph
Abstract
The TOR kinase, which is present in the functionally distinct complexes TORC1 and TORC2, is essential for growth but associated with disease and aging. Elucidation of how TOR influences life span will identify mechanisms of fundamental importance in aging and TOR functions. Here we show that when TORC1 is inhibited genetically in C. elegans, SKN-1/Nrf, and DAF-16/FoxO activate protective genes, and increase stress resistance and longevity. SKN-1 also upregulates TORC1 pathway gene expression in a feedback loop. Rapamycin triggers a similar protective response in C. elegans and mice, but increases worm life span dependent upon SKN-1 and not DAF-16, apparently by interfering with TORC2 along with TORC1. TORC1, TORC2, and insulin/IGF-1-like signaling regulate SKN-1 activity through different mechanisms. We conclude that modulation of SKN-1/Nrf and DAF-16/FoxO may be generally important in the effects of TOR signaling in vivo and that these transcription factors mediate an opposing relationship between growth signals and longevity.

Temperature °C
20
Diet
NGM
Lifespan (days)
24.71
Lifespan comparisons
Double mutant ragc-1(RNAi);rde-1(ne219) has a lifespan of 24.71 days, while single mutant rde-1(ne219) has a lifespan of 24.8 days.
Citation
View abstract
Robida-Stubbs S et al., 2012, TOR signaling and rapamycin influence longevity by regulating SKN-1/Nrf and DAF-16/FoxO. Cell Metab. 15(5):713-24 22560223 Click here to select all mutants from this PubMed ID in the graph
Abstract
The TOR kinase, which is present in the functionally distinct complexes TORC1 and TORC2, is essential for growth but associated with disease and aging. Elucidation of how TOR influences life span will identify mechanisms of fundamental importance in aging and TOR functions. Here we show that when TORC1 is inhibited genetically in C. elegans, SKN-1/Nrf, and DAF-16/FoxO activate protective genes, and increase stress resistance and longevity. SKN-1 also upregulates TORC1 pathway gene expression in a feedback loop. Rapamycin triggers a similar protective response in C. elegans and mice, but increases worm life span dependent upon SKN-1 and not DAF-16, apparently by interfering with TORC2 along with TORC1. TORC1, TORC2, and insulin/IGF-1-like signaling regulate SKN-1 activity through different mechanisms. We conclude that modulation of SKN-1/Nrf and DAF-16/FoxO may be generally important in the effects of TOR signaling in vivo and that these transcription factors mediate an opposing relationship between growth signals and longevity.

Search genes: ragc-1 rde-1

Entrez ID
Symbol
GenAge
Wormbase ID

178084
ragc-1
View on GenAge (ragc-1)
WBGene00012497

RAs-related GTP binding protein C homolog

Locus: CELE_Y24F12A.2

Wormbase description: none available

Entrez ID
Symbol
GenAge
Wormbase ID

179393
rde-1
View on GenAge (rde-1)
WBGene00004323

hypothetical protein

Locus: CELE_K08H10.7

Wormbase description: rde-1 encodes a member of the Argonaute (SGO) and PIWI family of proteins; rde-1 activity is required for RNA-mediated interference (RNAi); specifically, in RNAi induced by exogenous dsRNA, RDE-1 acts as the siRNA acceptor for siRNAs produced by DCR-1-mediated cleavage; subsequently, RDE-1 directs a multi-protein complex to homologous mRNA targets to trigger their destabilization and degradation; RDE-1 physically interacts with the dsRNA binding protein RDE-4 in vivo and RDE-1 activity is also required for accumulation of dsRNA bound to RDE-4.

Orthologs of ragc-1;rde-1 in SynergyAge

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Species	Gene

Not in SynergyAge
Species	Gene

Orthologs of ragc-1 in SynergyAge

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Species	Gene

Not in SynergyAge
Species	Gene
Drosophila melanogaster	RagC-D
Mus musculus	Rragd
Mus musculus	Rragc

Orthologs of rde-1 in SynergyAge

Show in SynergyAge
Species	Gene