Lifespan changes: From wild type to aak-1;frh-1 / From aak-1;frh-1 to multiple mutants

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Genetic mutants with aak-1, frh-1 alterations

    Names of genes are ordered alphabetically. For the order of interventions, please see the specific paper.
  • Temperature °C


  • Diet


  • Lifespan (days)


  • Lifespan change (compared to wild type)


  • Phenotype

    The kinase involved in energy metabolism that we tested (aak-1) affected longevity induced by RNAi-mediated Mit mutants analyzed other than frh-1 RNAi.

  • Lifespan comparisons

    Double mutant aak-1(tm1994);frh-1(RNAi) has a lifespan of 21.5 days, while single mutant frh-1(RNAi) has a lifespan of 20.6 days, single mutant aak-1(tm1994) has a lifespan of 16.5 days and wild type has a lifespan of 17.2 days.

  • Type of interaction
    See methods

    Opposite lifespan effects of single mutants

  • Citation
    View abstract

    Schiavi A et al., 2013, Autophagy induction extends lifespan and reduces lipid content in response to frataxin silencing in C. elegans. Exp Gerontol. 48(2):191-201 PubMed 23247094 Click here to select all mutants from this PubMed ID in the graph

Search genes: aak-1 frh-1
  • Entrez ID
  • Symbol
  • GenAge
  • Wormbase ID

5'-AMP-activated protein kinase catalytic subunit alpha-1

Locus: CELE_PAR2.3

Wormbase description: aak-1 encodes one of two C. elegans homologs of the catalytic alpha subunit of AMP-activated protein kinases (AMPKs); aak-1 activity is required, in parallel with aak-2 and downstream of daf-2, daf-7, and par-4, for negative regulation of germline proliferation during dauer development.

  • Entrez ID
  • Symbol
  • GenAge
  • Wormbase ID

Frataxin, mitochondrial

Locus: CELE_F59G1.7

Wormbase description: frh-1 encodes the C. elegans frataxin ortholog; by homology, FRH-1 is predicted to be a mitochondrial protein required for biogenesis of iron-sulfur clusters, co-factors necessary for proper function of electron transport chain proteins; in C. elegans, loss of frh-1 activity via RNAi results in small body size, pale coloration, reduced motility, decreased pharyngeal pumping and defecation, reduced egg-laying and fertility, hypersensitivity to oxidative stress, and altered adult lifespan; an frh-1::gfp promoter fusion is expressed in neurons, the pharynx, gut, spermatheca and body wall muscle; in the pharynx, FRH-1 localizes to the mitochondria.

Orthologs of aak-1;frh-1 in SynergyAge
Show in SynergyAge
Species Gene
Orthologs of aak-1 in SynergyAge
Show in SynergyAge
Species Gene
Orthologs of frh-1 in SynergyAge
Show in SynergyAge
Species Gene

SynergyAge database hosts high-quality, manually curated information about the synergistic and antagonistic lifespan effects of genetic interventions in model organisms, also allowing users to explore the longevity relationships between genes in a visual way.

Read more about SynergyAge database

How to cite us

If you would like to cite this database please use:

Bunu, G., Toren, D., Ion, C. et al. SynergyAge, a curated database for synergistic and antagonistic interactions of longevity-associated genes. Sci Data 7, 366 (2020). https://doi.org/10.1038/s41597-020-00710-z

Robi Tacutu, Ph.D.
Head: Systems Biology of Aging Group, Bioinformatics & Structural Biochemistry Department
Institute of Biochemistry, Ground floor
Splaiul Independentei 296, Bucharest, Romania

Group webpage: www.aging-research.group