bec-1;frh-1

Lifespan changes: From wild type to bec-1;frh-1

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Genetic mutants with bec-1, frh-1 alterations

    Names of genes are ordered alphabetically. For the order of interventions, please see the specific paper.
  • Temperature °C

    20

  • Diet

    NGM

  • Lifespan (days)

    16.7

  • Lifespan change (compared to wild type)

    -9.24%

  • Phenotype

    RNAi of bec-1 shortened animal lifespan, and completely abolished the lifespan extension induced by frh-1 RNAi.

  • Lifespan comparisons

    Double mutant bec-1(RNAi);frh-1(RNAi) has a lifespan of 16.7 days, while single mutant bec-1(RNAi) has a lifespan of 16.8 days, single mutant frh-1(RNAi) has a lifespan of 23.1 days and wild type has a lifespan of 18.4 days.

  • Type of interaction
    See methods

    Opposite lifespan effects of single mutants

  • Citation
    View abstract

    Schiavi A et al., 2013, Autophagy induction extends lifespan and reduces lipid content in response to frataxin silencing in C. elegans. Exp Gerontol. 48(2):191-201 PubMed 23247094 Click here to select all mutants from this PubMed ID in the graph

    Names of genes are ordered alphabetically. For the order of interventions, please see the specific paper.
  • Temperature °C

    20

  • Diet

    NGM

  • Lifespan (days)

    8.4

  • Lifespan change (compared to wild type)

    -54.35%

  • Phenotype

    Genetic suppression of bec-1 shortened animal lifespan, and completely abolished the lifespan extension induced by frh-1 RNAi.

  • Lifespan comparisons

    Double mutant bec-1(ok691);frh-1(RNAi) has a lifespan of 8.4 days, while single mutant frh-1(RNAi) has a lifespan of 23.1 days, single mutant bec-1(ok691) has a lifespan of 9.9 days and wild type has a lifespan of 18.4 days.

  • Type of interaction
    See methods

    Enhancer, opposite lifespan effects

  • Citation
    View abstract

    Schiavi A et al., 2013, Autophagy induction extends lifespan and reduces lipid content in response to frataxin silencing in C. elegans. Exp Gerontol. 48(2):191-201 PubMed 23247094 Click here to select all mutants from this PubMed ID in the graph

Search genes: bec-1 frh-1
  • Entrez ID
  • Symbol
  • GenAge
  • Wormbase ID

Beclin homolog


Locus: CELE_T19E7.3


Wormbase description: bec-1 encodes a coiled-coil protein orthologous to the yeast and mammalian autophagy proteins Atg6/Vps30/Beclin1; by homology, BEC-1 may be part of a Class III phosphatidylinositol 3-kinase complex that plays a role in localizing autophagy proteins to preautophagosomal structures and overexpression of C. elegans bec-1 in S. cerevisiae APG6/VPS30 mutants can rescue associated autophagy defects; bec-1 is also required for regulation of endocytic retrograde transport; in C. elegans, bec-1 activity is required for normal dauer morphogenesis and survival of dauer larvae, as well as for adult life span extension of daf-2(e1370) mutants at 15 degrees; in addition, bec-1(RNAi) indicates a role for bec-1 in normal growth rates, movement, and vulval morphogenesis; a bec-1::GFP reporter fusion is expressed in the hypodermis, intestine, nervous system, pharynx, and reproductive organs, all tissues that are remodeled during dauer larval development.


  • Entrez ID
  • Symbol
  • GenAge
  • Wormbase ID

Frataxin, mitochondrial


Locus: CELE_F59G1.7


Wormbase description: frh-1 encodes the C. elegans frataxin ortholog; by homology, FRH-1 is predicted to be a mitochondrial protein required for biogenesis of iron-sulfur clusters, co-factors necessary for proper function of electron transport chain proteins; in C. elegans, loss of frh-1 activity via RNAi results in small body size, pale coloration, reduced motility, decreased pharyngeal pumping and defecation, reduced egg-laying and fertility, hypersensitivity to oxidative stress, and altered adult lifespan; an frh-1::gfp promoter fusion is expressed in neurons, the pharynx, gut, spermatheca and body wall muscle; in the pharynx, FRH-1 localizes to the mitochondria.


Orthologs of bec-1;frh-1 in SynergyAge
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Orthologs of bec-1 in SynergyAge
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Orthologs of frh-1 in SynergyAge
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About

SynergyAge database hosts high-quality, manually curated information about the synergistic and antagonistic lifespan effects of genetic interventions in model organisms, also allowing users to explore the longevity relationships between genes in a visual way.

Read more about SynergyAge database

How to cite us

If you would like to cite this database please use:

Bunu, G., Toren, D., Ion, C. et al. SynergyAge, a curated database for synergistic and antagonistic interactions of longevity-associated genes. Sci Data 7, 366 (2020). https://doi.org/10.1038/s41597-020-00710-z

Contact
Robi Tacutu, Ph.D.
Head: Systems Biology of Aging Group, Bioinformatics & Structural Biochemistry Department
Institute of Biochemistry, Ground floor
Splaiul Independentei 296, Bucharest, Romania
Email:

Group webpage: www.aging-research.group