hsf-1;rps-6

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Genetic mutants with hsf-1, rps-6 alterations

Names of genes are ordered alphabetically. For the order of interventions, please see the specific paper.

Temperature °C
22.5
Diet
NGM
Lifespan (days)
12.1
Lifespan change (compared to wild type)
-34.24%
Phenotype
We found that increased lifespan conferred by knockdown of rps-6 was suppressed by hsf-1 mutations.
Lifespan comparisons
Double mutant hsf-1(sy441);rps-6(RNAi) has a lifespan of 12.1 days, while single mutant rps-6(RNAi) has a lifespan of 20.0 days, single mutant hsf-1(sy441) has a lifespan of 11.6 days and wild type has a lifespan of 18.4 days.
Type of interaction
See methods
Opposite lifespan effects of single mutants
Citation
View abstract
Seo K et al., 2013, Heat shock factor 1 mediates the longevity conferred by inhibition of TOR and insulin/IGF-1 signaling pathways in C. elegans. Aging Cell. 12(6):1073-81 23879233 Click here to select all mutants from this PubMed ID in the graph
Abstract
Target of rapamycin (TOR) signaling is an evolutionarily well-conserved pathway that regulates various physiologic processes, including aging and metabolism. One of the key downstream components of TOR signaling is ribosomal protein S6 kinase (S6K) whose inhibition extends the lifespan of yeast, Caenorhabditis elegans, Drosophila, and mice. Here, we demonstrate that the activation of heat shock factor 1 (HSF-1), a crucial longevity transcription factor known to act downstream of the insulin/IGF-1 signaling (IIS) pathway, mediates the prolonged lifespan conferred by mutations in C. elegans S6K (rsks-1). We found that hsf-1 is required for the longevity caused by down-regulation of components in TOR signaling pathways, including TOR and S6K. The induction of a small heat-shock protein hsp-16, a transcriptional target of HSF-1, mediates the long lifespan of rsks-1 mutants. Moreover, we show that synergistic activation of HSF-1 is required for the further enhanced longevity caused by simultaneous down-regulation of TOR and IIS pathways. Our findings suggest that HSF-1 acts as an essential longevity factor that intersects both IIS and TOR signaling pathways.

Temperature °C
22.5
Diet
NGM
Lifespan (days)
14.2
Lifespan change (compared to wild type)
-19.77%
Phenotype
We found that increased lifespan conferred by knockdown of rps-6 was suppressed by hsf-1 mutations.
Lifespan comparisons
Double mutant hsf-1(sy441);rps-6(RNAi) has a lifespan of 14.2 days, while single mutant rps-6(RNAi) has a lifespan of 19.4 days, single mutant hsf-1(sy441) has a lifespan of 13.2 days and wild type has a lifespan of 17.7 days.
Type of interaction
See methods
Opposite lifespan effects of single mutants
Citation
View abstract
Seo K et al., 2013, Heat shock factor 1 mediates the longevity conferred by inhibition of TOR and insulin/IGF-1 signaling pathways in C. elegans. Aging Cell. 12(6):1073-81 23879233 Click here to select all mutants from this PubMed ID in the graph
Abstract
Target of rapamycin (TOR) signaling is an evolutionarily well-conserved pathway that regulates various physiologic processes, including aging and metabolism. One of the key downstream components of TOR signaling is ribosomal protein S6 kinase (S6K) whose inhibition extends the lifespan of yeast, Caenorhabditis elegans, Drosophila, and mice. Here, we demonstrate that the activation of heat shock factor 1 (HSF-1), a crucial longevity transcription factor known to act downstream of the insulin/IGF-1 signaling (IIS) pathway, mediates the prolonged lifespan conferred by mutations in C. elegans S6K (rsks-1). We found that hsf-1 is required for the longevity caused by down-regulation of components in TOR signaling pathways, including TOR and S6K. The induction of a small heat-shock protein hsp-16, a transcriptional target of HSF-1, mediates the long lifespan of rsks-1 mutants. Moreover, we show that synergistic activation of HSF-1 is required for the further enhanced longevity caused by simultaneous down-regulation of TOR and IIS pathways. Our findings suggest that HSF-1 acts as an essential longevity factor that intersects both IIS and TOR signaling pathways.

Search genes: hsf-1 rps-6

Entrez ID
Symbol
GenAge
Wormbase ID

173078
hsf-1
View on GenAge (hsf-1)
WBGene00002004

Heat Shock Factor

Locus: CELE_Y53C10A.12

Wormbase description: hsf-1 encodes the C. elegans heat-shock transcription factor ortholog; HSF-1 functions as a transcriptional regulator of stress-induced gene expression whose activity is required for heat-shock and proteotoxicity response, larval development, innate immunity, and regulation of adult lifespan; HSF-1 binds bovine calmodulin in vitro in a calcium-dependent manner.

Entrez ID
Symbol
GenAge
Wormbase ID

173260
rps-6
View on GenAge (rps-6)
WBGene00004475

40S ribosomal protein S6;Ribosomal Protein, Small subunit

Locus: CELE_Y71A12B.1

Wormbase description: rps-6 encodes a small (40S) ribosomal subunit S6 protein; loss of rps-6 activity in adult animals extends lifespan.

Orthologs of hsf-1;rps-6 in SynergyAge

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Species	Gene

Not in SynergyAge
Species	Gene

Orthologs of hsf-1 in SynergyAge

Show in SynergyAge
Species	Gene

Orthologs of rps-6 in SynergyAge

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Species	Gene

Not in SynergyAge
Species	Gene
Drosophila melanogaster	RpS6
Mus musculus	Rps6
Mus musculus	LOC105244208