hsp-16.1;hsp-16.11;hsp-16.2

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Genetic mutants with hsp-16.1, hsp-16.11, hsp-16.2 alterations

Names of genes are ordered alphabetically. For the order of interventions, please see the specific paper.

Temperature °C
22.5
Diet
NGM
Lifespan (days)
16.9
Lifespan change (compared to wild type)
-5.06%
Lifespan comparisons
Triple mutant hsp-16.1(RNAi);hsp-16.11(RNAi);hsp-16.2(RNAi) has a lifespan of 16.9 days, while wild type has a lifespan of 17.8 days.
Citation
View abstract
Seo K et al., 2013, Heat shock factor 1 mediates the longevity conferred by inhibition of TOR and insulin/IGF-1 signaling pathways in C. elegans. Aging Cell. 12(6):1073-81 23879233 Click here to select all mutants from this PubMed ID in the graph
Abstract
Target of rapamycin (TOR) signaling is an evolutionarily well-conserved pathway that regulates various physiologic processes, including aging and metabolism. One of the key downstream components of TOR signaling is ribosomal protein S6 kinase (S6K) whose inhibition extends the lifespan of yeast, Caenorhabditis elegans, Drosophila, and mice. Here, we demonstrate that the activation of heat shock factor 1 (HSF-1), a crucial longevity transcription factor known to act downstream of the insulin/IGF-1 signaling (IIS) pathway, mediates the prolonged lifespan conferred by mutations in C. elegans S6K (rsks-1). We found that hsf-1 is required for the longevity caused by down-regulation of components in TOR signaling pathways, including TOR and S6K. The induction of a small heat-shock protein hsp-16, a transcriptional target of HSF-1, mediates the long lifespan of rsks-1 mutants. Moreover, we show that synergistic activation of HSF-1 is required for the further enhanced longevity caused by simultaneous down-regulation of TOR and IIS pathways. Our findings suggest that HSF-1 acts as an essential longevity factor that intersects both IIS and TOR signaling pathways.

Temperature °C
22.5
Diet
NGM
Lifespan (days)
14.5
Lifespan change (compared to wild type)
-10.49%
Lifespan comparisons
Triple mutant hsp-16.1(RNAi);hsp-16.11(RNAi);hsp-16.2(RNAi) has a lifespan of 14.5 days, while wild type has a lifespan of 16.2 days.
Citation
View abstract
Seo K et al., 2013, Heat shock factor 1 mediates the longevity conferred by inhibition of TOR and insulin/IGF-1 signaling pathways in C. elegans. Aging Cell. 12(6):1073-81 23879233 Click here to select all mutants from this PubMed ID in the graph
Abstract
Target of rapamycin (TOR) signaling is an evolutionarily well-conserved pathway that regulates various physiologic processes, including aging and metabolism. One of the key downstream components of TOR signaling is ribosomal protein S6 kinase (S6K) whose inhibition extends the lifespan of yeast, Caenorhabditis elegans, Drosophila, and mice. Here, we demonstrate that the activation of heat shock factor 1 (HSF-1), a crucial longevity transcription factor known to act downstream of the insulin/IGF-1 signaling (IIS) pathway, mediates the prolonged lifespan conferred by mutations in C. elegans S6K (rsks-1). We found that hsf-1 is required for the longevity caused by down-regulation of components in TOR signaling pathways, including TOR and S6K. The induction of a small heat-shock protein hsp-16, a transcriptional target of HSF-1, mediates the long lifespan of rsks-1 mutants. Moreover, we show that synergistic activation of HSF-1 is required for the further enhanced longevity caused by simultaneous down-regulation of TOR and IIS pathways. Our findings suggest that HSF-1 acts as an essential longevity factor that intersects both IIS and TOR signaling pathways.

Search genes: hsp-16.1 hsp-16.11 hsp-16.2 hsp-16.1;hsp-16.11;hsp-16.2

Entrez ID
Symbol
GenAge
Wormbase ID

179286
hsp-16.1
View on GenAge (hsp-16.1)
WBGene00002015

Heat shock protein Hsp-16.1/Hsp-16.11

Locus: CELE_T27E4.8

Wormbase description: hsp-16.1 encodes a 16-kD heat shock protein (HSP) that is a member of the hsp16/hsp20/alphaB-crystallin (HSP16) family of heat shock proteins, and that is identical to the protein encoded by hsp-16.11; an hsp-16.1 reporter fusion, expressed broadly but most strongly in muscle and hypodermis, is induced solely in response to heat shock or other environmental stresses; expression is detectable in somatic tissues in post-gastrulation embryos, all larval stages, and in adults; HSP-16.1 is likely to function as a passive ligand temporarily preventing unfolded proteins from aggregating.

Entrez ID
Symbol
GenAge
Wormbase ID

179289
hsp-16.11
View on GenAge (hsp-16.11)
WBGene00002017

Heat shock protein Hsp-16.1/Hsp-16.11

Locus: CELE_T27E4.2

Wormbase description: hsp-16.11 encodes a 16-kD heat shock protein (HSP) that is a member of the hsp16/hsp20/alphaB-crystallin (HSP16) family of heat shock proteins, and that is identical to the protein encoded by hsp-16.1; hsp-16.11 expression is induced in response to heat shock or other environmental stresses; HSP-16.11 is likely to function as passive ligand temporarily preventing unfolded proteins from aggregating; HSP-16.11 has been shown to interact with intracellular human beta amyloid peptide, a primary component of the extracellular plaques found in Alzheimer's disease.

Entrez ID
Symbol
GenAge
Wormbase ID

178659
hsp-16.2
View on GenAge (hsp-16.2)
WBGene00002016

Heat Shock Protein;Heat shock protein Hsp-16.2

Locus: CELE_Y46H3A.3

Wormbase description: hsp-16.2 encodes a 16-kD heat shock protein (HSP) that is a member of the hsp16/hsp20/alphaB-crystallin (HSP16) family of heat shock proteins; hsp-16.2 expression, strongest in intestine and pharynx, is induced in response to heat shock or other environmental stresses; HSP-16.2 has been shown to interact with intracellular human beta amyloid peptide, a primary component of the extracellular plaques found in Alzheimer's disease; HSP-16.2 is likely to function as a passive ligand temporarily preventing unfolded proteins from aggregating.

Orthologs of hsp-16.1;hsp-16.11;hsp-16.2 in SynergyAge

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Species	Gene

Not in SynergyAge
Species	Gene
Drosophila melanogaster	Hsp22;Hsp22;Hsp22
Drosophila melanogaster	Hsp22;Hsp22;Hsp23
Drosophila melanogaster	Hsp22;Hsp22;Hsp26
Drosophila melanogaster	Hsp22;Hsp22;Hsp27
Drosophila melanogaster	Hsp22;Hsp22;Hsp67Bc
Drosophila melanogaster	Hsp22;Hsp23;Hsp23
Drosophila melanogaster	Hsp22;Hsp23;Hsp26
Drosophila melanogaster	Hsp22;Hsp23;Hsp27
Drosophila melanogaster	Hsp22;Hsp23;Hsp67Bc
Drosophila melanogaster	Hsp22;Hsp26;Hsp26
Drosophila melanogaster	Hsp22;Hsp26;Hsp27
Drosophila melanogaster	Hsp22;Hsp26;Hsp67Bc
Drosophila melanogaster	Hsp22;Hsp27;Hsp27
Drosophila melanogaster	Hsp22;Hsp27;Hsp67Bc
Drosophila melanogaster	Hsp22;Hsp67Bc;Hsp67Bc
Drosophila melanogaster	Hsp23;Hsp23;Hsp23
Drosophila melanogaster	Hsp23;Hsp23;Hsp26
Drosophila melanogaster	Hsp23;Hsp23;Hsp27
Drosophila melanogaster	Hsp23;Hsp23;Hsp67Bc
Drosophila melanogaster	Hsp23;Hsp26;Hsp26
Drosophila melanogaster	Hsp23;Hsp26;Hsp27
Drosophila melanogaster	Hsp23;Hsp26;Hsp67Bc
Drosophila melanogaster	Hsp23;Hsp27;Hsp27
Drosophila melanogaster	Hsp23;Hsp27;Hsp67Bc
Drosophila melanogaster	Hsp23;Hsp67Bc;Hsp67Bc
Drosophila melanogaster	Hsp26;Hsp26;Hsp26
Drosophila melanogaster	Hsp26;Hsp26;Hsp27
Drosophila melanogaster	Hsp26;Hsp26;Hsp67Bc
Drosophila melanogaster	Hsp26;Hsp27;Hsp27
Drosophila melanogaster	Hsp26;Hsp27;Hsp67Bc
Drosophila melanogaster	Hsp26;Hsp67Bc;Hsp67Bc
Drosophila melanogaster	Hsp27;Hsp27;Hsp27
Drosophila melanogaster	Hsp27;Hsp27;Hsp67Bc
Drosophila melanogaster	Hsp27;Hsp67Bc;Hsp67Bc
Drosophila melanogaster	Hsp67Bc;Hsp67Bc;Hsp67Bc

Orthologs of hsp-16.1 in SynergyAge

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Species	Gene

Orthologs of hsp-16.11 in SynergyAge

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Species	Gene

Orthologs of hsp-16.2 in SynergyAge

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Species	Gene