Lifespan changes: From wild type to aakg-5;rrf-3

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Genetic mutants with aakg-5, rrf-3 alterations

    Names of genes are ordered alphabetically. For the order of interventions, please see the specific paper.
  • Temperature °C


  • Diet


  • Lifespan (days)


  • Lifespan comparisons

    Double mutant aakg-5(RNAi);rrf-3(pk1426) has a lifespan of 12.0 days, while single mutant rrf-3(pk1426) has a lifespan of 12.1 days.

  • Citation
    View abstract

    Tullet JM et al., 2014, DAF-16/FoxO directly regulates an atypical AMP-activated protein kinase gamma isoform to mediate the effects of insulin/IGF-1 signaling on aging in Caenorhabditis elegans. PLoS Genet. 10(2):e1004109 PubMed 24516399 Click here to select all mutants from this PubMed ID in the graph

Search genes: aakg-5 rrf-3
  • Entrez ID
  • Symbol
  • GenAge
  • Wormbase ID

AMP-Activated protein Kinase Gamma subunit

Locus: CELE_R53.7

Wormbase description: aakg-5 encodes one of five C. elegans AMP kinase (AMPK) gamma regulatory subunits.

  • Entrez ID
  • Symbol
  • GenAge
  • Wormbase ID

RNA-dependent RNA polymerase Family

Locus: CELE_F10B5.7

Wormbase description: rrf-3 encodes an RNA-directed RNA polymerase (RdRP) homolog that inhibits somatic RNAi, and thus promotes activity of repeated genes (e.g., multicopy transgenic arrays); the effect of RRF-3 on RNAi is opposite to that of RRF-1 (which stimulates somatic RNAi), which might arise from competition by RRF-3 with RRF-1 or EGO-1 in RNAi formation; rrf-3(allele) or rrf-3(allele2) mutants are hypersensitive to somatic RNAi, and conversely suppress the activity of an integrated rol6 (su1006) transgene.

Orthologs of aakg-5;rrf-3 in SynergyAge
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Species Gene
Orthologs of aakg-5 in SynergyAge
Show in SynergyAge
Species Gene
Orthologs of rrf-3 in SynergyAge
Show in SynergyAge
Species Gene

SynergyAge database hosts high-quality, manually curated information about the synergistic and antagonistic lifespan effects of genetic interventions in model organisms, also allowing users to explore the longevity relationships between genes in a visual way.

Read more about SynergyAge database

How to cite us

If you would like to cite this database please use:

Bunu, G., Toren, D., Ion, C. et al. SynergyAge, a curated database for synergistic and antagonistic interactions of longevity-associated genes. Sci Data 7, 366 (2020). https://doi.org/10.1038/s41597-020-00710-z

Robi Tacutu, Ph.D.
Head: Systems Biology of Aging Group, Bioinformatics & Structural Biochemistry Department
Institute of Biochemistry, Ground floor
Splaiul Independentei 296, Bucharest, Romania

Group webpage: www.aging-research.group