atm-1;frh-1

Lifespan changes: From wild type to atm-1;frh-1

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Genetic mutants with atm-1, frh-1 alterations

    Names of genes are ordered alphabetically. For the order of interventions, please see the specific paper.
  • Temperature °C

    20

  • Lifespan (days)

    25.66

  • Lifespan change (compared to wild type)

    54.02%

  • Phenotype

    atm-1(gk186) play no apparent role in the life extension that occurs following mild frh-1 RNAi treatment.

  • Lifespan comparisons

    Double mutant atm-1(gk186);frh-1(RNAi) has a lifespan of 25.66 days, while single mutant frh-1(RNAi) has a lifespan of 19.66 days, single mutant atm-1(gk186) has a lifespan of 21.33 days and wild type has a lifespan of 16.66 days.

  • Type of interaction
    See methods

    Synergistic (positive)

  • Citation
    View abstract

    Ventura N et al., 2009, p53/CEP-1 increases or decreases lifespan, depending on level of mitochondrial bioenergetic stress. Aging Cell. 8(4):380-93 PubMed 19416129 Click here to select all mutants from this PubMed ID in the graph

  • Temperature °C

    20

  • Lifespan (days)

    26.2

  • Lifespan change (compared to wild type)

    60.74%

  • Lifespan comparisons

    Double mutant atm-1(gk186);frh-1(RNAi) has a lifespan of 26.2 days, while single mutant frh-1(RNAi) has a lifespan of 21.3 days, single mutant atm-1(gk186) has a lifespan of 19.5 days and wild type has a lifespan of 16.3 days.

  • Type of interaction
    See methods

    Synergistic (positive)

  • Citation
    View abstract

    Ventura N et al., 2009, p53/CEP-1 increases or decreases lifespan, depending on level of mitochondrial bioenergetic stress. Aging Cell. 8(4):380-93 PubMed 19416129 Click here to select all mutants from this PubMed ID in the graph

Search genes: atm-1 frh-1
  • Entrez ID
  • Symbol
  • GenAge
  • Wormbase ID

Serine/threonine-protein kinase ATM


Locus: CELE_Y48G1BL.2


Wormbase description: atm-1 encodes an ortholog of human ATM that is required for the checkpoint response to DNA damage; human ATM encodes a phosphatidylinositol-3 kinase homolog that is biochemically activated by cellular irradiation.


  • Entrez ID
  • Symbol
  • GenAge
  • Wormbase ID

Frataxin, mitochondrial


Locus: CELE_F59G1.7


Wormbase description: frh-1 encodes the C. elegans frataxin ortholog; by homology, FRH-1 is predicted to be a mitochondrial protein required for biogenesis of iron-sulfur clusters, co-factors necessary for proper function of electron transport chain proteins; in C. elegans, loss of frh-1 activity via RNAi results in small body size, pale coloration, reduced motility, decreased pharyngeal pumping and defecation, reduced egg-laying and fertility, hypersensitivity to oxidative stress, and altered adult lifespan; an frh-1::gfp promoter fusion is expressed in neurons, the pharynx, gut, spermatheca and body wall muscle; in the pharynx, FRH-1 localizes to the mitochondria.


Orthologs of atm-1;frh-1 in SynergyAge
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Species Gene
Orthologs of atm-1 in SynergyAge
Show in SynergyAge
Species Gene
Orthologs of frh-1 in SynergyAge
Show in SynergyAge
Species Gene
About

SynergyAge database hosts high-quality, manually curated information about the synergistic and antagonistic lifespan effects of genetic interventions in model organisms, also allowing users to explore the longevity relationships between genes in a visual way.

Read more about SynergyAge database

How to cite us

If you would like to cite this database please use:

Bunu, G., Toren, D., Ion, C. et al. SynergyAge, a curated database for synergistic and antagonistic interactions of longevity-associated genes. Sci Data 7, 366 (2020). https://doi.org/10.1038/s41597-020-00710-z

Contact
Robi Tacutu, Ph.D.
Head: Systems Biology of Aging Group, Bioinformatics & Structural Biochemistry Department
Institute of Biochemistry, Ground floor
Splaiul Independentei 296, Bucharest, Romania
Email:

Group webpage: www.aging-research.group