atm-1;atp-3

Lifespan changes: From wild type to atm-1;atp-3

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Genetic mutants with atm-1, atp-3 alterations

    Names of genes are ordered alphabetically. For the order of interventions, please see the specific paper.
  • Temperature °C

    20

  • Lifespan (days)

    4.25

  • Lifespan change (compared to wild type)

    -75.00%

  • Phenotype

    atm-1 plays no obvious role in the life shortening that occurs following treatment with undiluted atp-3 RNAi.

  • Lifespan comparisons

    Double mutant atm-1(gk186);atp-3(RNAi) has a lifespan of 4.25 days, while single mutant atp-3(RNAi) has a lifespan of 5.0 days, single mutant atm-1(gk186) has a lifespan of 20.5 days and wild type has a lifespan of 17.0 days.

  • Type of interaction
    See methods

    Opposite lifespan effects of single mutants

  • Citation
    View abstract

    Ventura N et al., 2009, p53/CEP-1 increases or decreases lifespan, depending on level of mitochondrial bioenergetic stress. Aging Cell. 8(4):380-93 PubMed 19416129 Click here to select all mutants from this PubMed ID in the graph

  • Temperature °C

    20

  • Lifespan (days)

    5.1

  • Lifespan change (compared to wild type)

    -68.71%

  • Phenotype

    The atm-1(gk186) plays no obvious role in the life shortening that occurs following treatment with undiluted atp-3 RNAi.

  • Lifespan comparisons

    Double mutant atm-1(gk186);atp-3(RNAi) has a lifespan of 5.1 days, while single mutant atp-3(RNAi) has a lifespan of 5.3 days, single mutant atm-1(gk186) has a lifespan of 19.5 days and wild type has a lifespan of 16.3 days.

  • Type of interaction
    See methods

    Opposite lifespan effects of single mutants

  • Citation
    View abstract

    Ventura N et al., 2009, p53/CEP-1 increases or decreases lifespan, depending on level of mitochondrial bioenergetic stress. Aging Cell. 8(4):380-93 PubMed 19416129 Click here to select all mutants from this PubMed ID in the graph

Search genes: atm-1 atp-3
  • Entrez ID
  • Symbol
  • GenAge
  • Wormbase ID

Serine/threonine-protein kinase ATM


Locus: CELE_Y48G1BL.2


Wormbase description: atm-1 encodes an ortholog of human ATM that is required for the checkpoint response to DNA damage; human ATM encodes a phosphatidylinositol-3 kinase homolog that is biochemically activated by cellular irradiation.


  • Entrez ID
  • Symbol
  • GenAge
  • Wormbase ID

ATP synthase subunit


Locus: CELE_F27C1.7


Wormbase description: atp-3 encodes the C. elegans homolog of the ATP5O subunit of mitochondrial ATP synthase (complex V); as part of the ATP synthase complex, ATP-3 controls respiration and regulates growth rate and body size, aging, and rates of behaviors such as pharyngeal pumping, defecation, and locomotion; loss of atp-3 function during larval development indicates that respiratory rates established during development persist into adulthood.


Orthologs of atm-1;atp-3 in SynergyAge
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Species Gene
Orthologs of atm-1 in SynergyAge
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Species Gene
Orthologs of atp-3 in SynergyAge
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Species Gene
About

SynergyAge database hosts high-quality, manually curated information about the synergistic and antagonistic lifespan effects of genetic interventions in model organisms, also allowing users to explore the longevity relationships between genes in a visual way.

Read more about SynergyAge database

How to cite us

If you would like to cite this database please use:

Bunu, G., Toren, D., Ion, C. et al. SynergyAge, a curated database for synergistic and antagonistic interactions of longevity-associated genes. Sci Data 7, 366 (2020). https://doi.org/10.1038/s41597-020-00710-z

Contact
Robi Tacutu, Ph.D.
Head: Systems Biology of Aging Group, Bioinformatics & Structural Biochemistry Department
Institute of Biochemistry, Ground floor
Splaiul Independentei 296, Bucharest, Romania
Email:

Group webpage: www.aging-research.group