Lifespan changes: From wild type to sir-2.1;unc-64

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Genetic mutants with sir-2.1, unc-64 alterations

    Names of genes are ordered alphabetically. For the order of interventions, please see the specific paper.
  • Temperature °C


  • Diet


  • Lifespan (days)


  • Lifespan change (compared to wild type)


  • Phenotype

    sir-2.1(ok434) does not suppress the longevity of unc-64(e246).

  • Lifespan comparisons

    Double mutant sir-2.1(ok434);unc-64(e246) has a lifespan of 40.1 days, while single mutant sir-2.1(ok434) has a lifespan of 15.4 days, single mutant unc-64(e246) has a lifespan of 40.3 days and wild type has a lifespan of 16.2 days.

  • Type of interaction
    See methods

    Opposite lifespan effects of single mutants

  • Citation
    View abstract

    Wang Y, Tissenbaum HA, 2006, Overlapping and distinct functions for a Caenorhabditis elegans SIR2 and DAF-16/FOXO. Mech Ageing Dev. 127(1):48-56 PubMed 16280150 Click here to select all mutants from this PubMed ID in the graph

Search genes: sir-2.1 unc-64
  • Entrez ID
  • Symbol
  • GenAge
  • Wormbase ID

NAD-dependent protein deacetylase sir-2.1;yeast SIR related

Locus: CELE_R11A8.4

Wormbase description: sir-2.1 encodes an NAD-dependent protein deacetylase with similarity to Saccharomyces cerevisiae Sir2p and mammalian SIRT1.

  • Entrez ID
  • Symbol
  • GenAge
  • Wormbase ID

Syntaxin-1A homolog

Locus: CELE_F56A8.7

Wormbase description: unc-64 encodes syntaxin, a plasma membrane receptor for intracellular vesicles that is orthologous to vertebrate syntaxin 1A (OMIM:186590) and Drosophila Syx1A; UNC-64 is required for normal locomotion and possibly also for insulin secretion; as an essential component of the core synaptic vesicle fusion machinery, UNC-64 interacts with UNC-13, a diacylglycerol-binding protein, and SNB-1/synaptobrevin; UNC-64 trafficking from the endoplasmic reticulum to the plasma membrane is mediated by UNC-18, an SM (Sec1, Munc18) family member; unc-64 mutations can be suppressed by mutations in slo-1, a calcium-activated potassium channel; UNC-64 is expressed ubiquitously in the nervous system and in secretory cells such as the vulval uv1 cell and the excretory gland cells.

Orthologs of sir-2.1;unc-64 in SynergyAge
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Species Gene
Orthologs of sir-2.1 in SynergyAge
Show in SynergyAge
Species Gene
Orthologs of unc-64 in SynergyAge
Show in SynergyAge
Species Gene

SynergyAge database hosts high-quality, manually curated information about the synergistic and antagonistic lifespan effects of genetic interventions in model organisms, also allowing users to explore the longevity relationships between genes in a visual way.

Read more about SynergyAge database

How to cite us

If you would like to cite this database please use:

Bunu, G., Toren, D., Ion, C. et al. SynergyAge, a curated database for synergistic and antagonistic interactions of longevity-associated genes. Sci Data 7, 366 (2020).

Robi Tacutu, Ph.D.
Head: Systems Biology of Aging Group, Bioinformatics & Structural Biochemistry Department
Institute of Biochemistry, Ground floor
Splaiul Independentei 296, Bucharest, Romania

Group webpage: