sod-1;sod-2;sod-3;sod-4;sod-5

Lifespan changes: From sod-1;sod-2;sod-3;sod-4;sod-5 to multiple mutants

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Genetic mutants with sod-1, sod-2, sod-3, sod-4, sod-5 alterations

    Names of genes are ordered alphabetically. For the order of interventions, please see the specific paper.
  • Temperature °C

    20

  • Diet

    NGM;OP50

  • Lifespan (days)

    13.63

  • Lifespan change (compared to wild type)

    15.41%

  • Lifespan comparisons

    Quintuple mutant sod-1(tm783);sod-2(ok1030);sod-3(tm760);sod-4(gk101);sod-5(tm1146) has a lifespan of 13.63 days, while wild type has a lifespan of 11.81 days.

  • Citation
    View abstract

    Dues DJ et al., 2019, Resistance to Stress Can Be Experimentally Dissociated From Longevity. J Gerontol A Biol Sci Med Sci. 74(8):1206-1214 PubMed 30247515 Click here to select all mutants from this PubMed ID in the graph

Search genes: sod-1 sod-2 sod-3 sod-4 sod-5 sod-1;sod-2;sod-3;sod-4;sod-5
  • Entrez ID
  • Symbol
  • GenAge
  • Wormbase ID

Superoxide dismutase [Cu-Zn]


Locus: CELE_C15F1.7


Wormbase description: sod-1 encodes the copper/zinc superoxide dismustase, an enzyme that is known to protect cells from oxidative damage; superoxide dismutase activity can be detected in worm extracts; sod-1 activity has been implicated in the increased life-span of dauer larvae where this enzyme demonstrates the highest activity compared to other life-stages as well as in the increased life span of age-1 mutants and their resistance to oxidative damage; sod-1 modulates the effect of let-60 ras on vulval and germline development via cytoplasmic reactive oxygen species; unlike other eukaryotic superoxide dismutases, sod-1 does not require the copper chaperone CCS for its activity and instead uses a glutathione pathway for acquiring copper; in humans, mutation of SOD1 (OMIM:147450) leads to amyotrophic lateral sclerosis (OMIM:105400).


  • Entrez ID
  • Symbol
  • GenAge
  • Wormbase ID

Superoxide dismutase [Mn] 1, mitochondrial


Locus: CELE_F10D11.1


Wormbase description: sod-2 encodes a iron/manganese superoxide dismutase, predicted to be mitochondrial, that might defend against oxidative stress and promote normal lifespan; sod-2 mRNA levels are diminished by mutation of daf-16, and heterologously expressed SOD-2 in E. coli protects against methyl viologen-induced oxidative stress.


  • Entrez ID
  • Symbol
  • GenAge
  • Wormbase ID

Superoxide dismutase [Mn] 2, mitochondrial


Locus: CELE_C08A9.1


Wormbase description: sod-3 encodes a iron/manganese superoxide dismutase, predicted to be mitochondrial, that might defend against oxidative stress and promote normal lifespan; sod-3 mRNA levels are diminished by mutation of daf-16 and chromatin immunoprecipitation (ChIP) studies demonstrate that DAF-16 can directly bind the sod-3 promoter; heterologously expressed SOD-3 in E. coli protects against methyl viologen-induced oxidative stress.


  • Entrez ID
  • Symbol
  • GenAge
  • Wormbase ID

Extracellular superoxide dismutase [Cu-Zn];Superoxide dismutase [Cu-Zn]


Locus: CELE_F55H2.1


Wormbase description: sod-4 encodes an extracellular Cu2+/Zn2+ superoxide dismutase (SOD) that is one of five C. elegans SOD enzymes; genetic analyses indicates that sod-4 is required for redox regulation of a number of processes including axon pathfinding in the PVQ interneurons, insulin/IGF-1 signaling, and vulval development; large-scale expression studies indicate that sod-4 is expressed in the nervous system, intestine, and rectal gland cells; sod-4 transcripts are significantly upregulated in dauers.


  • Entrez ID
  • Symbol
  • GenAge
  • Wormbase ID

Superoxide dismutase [Cu-Zn]


Locus: CELE_ZK430.3


Wormbase description: sod-5 encodes one of five superoxide (SOD) isozymes in C. elegans; along with SOD-1, SOD-5 is predicted to be one of two cytoplasmic Cu/Zn SODs in C. elegans; sod-5 expression is increased in sod-1 mutant animals and likewise, sod-1 expression is increased in sod-5 mutants, suggesting a possible mechanism of functional compensation between these two genes; the sod-5 promoter contains one copy of a DAF-16 binding element, consistent with observations that sod-5 mRNA levels increase in insulin/IGF-1 signaling pathway mutants.


Orthologs of sod-1;sod-2;sod-3;sod-4;sod-5 in SynergyAge
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Species Gene
Orthologs of sod-1 in SynergyAge
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Species Gene
Drosophila melanogaster Sod1
Mus musculus Sod1
Orthologs of sod-2 in SynergyAge
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Species Gene
Drosophila melanogaster Sod2
Orthologs of sod-3 in SynergyAge
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Species Gene
Drosophila melanogaster Sod2
Orthologs of sod-4 in SynergyAge
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Species Gene
Orthologs of sod-5 in SynergyAge
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Species Gene
Drosophila melanogaster Sod1
Mus musculus Sod1
About

SynergyAge database hosts high-quality, manually curated information about the synergistic and antagonistic lifespan effects of genetic interventions in model organisms, also allowing users to explore the longevity relationships between genes in a visual way.

Read more about SynergyAge database

How to cite us

If you would like to cite this database please use:

Bunu, G., Toren, D., Ion, C. et al. SynergyAge, a curated database for synergistic and antagonistic interactions of longevity-associated genes. Sci Data 7, 366 (2020). https://doi.org/10.1038/s41597-020-00710-z

Contact
Robi Tacutu, Ph.D.
Head: Systems Biology of Aging Group, Bioinformatics & Structural Biochemistry Department
Institute of Biochemistry, Ground floor
Splaiul Independentei 296, Bucharest, Romania
Email:

Group webpage: www.aging-research.group