cdk-2;daf-16

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Genetic mutants with cdk-2, daf-16 alterations

Names of genes are ordered alphabetically. For the order of interventions, please see the specific paper.

Temperature °C
20
Diet
NGM
Lifespan (days)
18.4
Lifespan change (compared to wild type)
-2.13%
Phenotype
The dramatic lifespan extension associated with knockdown of cdk-2 was not fully eliminated in daf-16(mgDf47) null mutants indicating that DAF-16 is central for the influence of cell cycle regulators on longevity.
Lifespan comparisons
Double mutant cdk-2(RNAi);daf-16(mgDf47) has a lifespan of 18.4 days, while single mutant cdk-2(RNAi) has a lifespan of 24.1 days, single mutant daf-16(mgDf47) has a lifespan of 16.8 days and wild type has a lifespan of 18.8 days.
Type of interaction
See methods
Opposite lifespan effects of single mutants
Citation
View abstract
Dottermusch M et al., 2016, Cell cycle controls stress response and longevity in C. elegans. Aging (Albany NY). 8(9):2100-2126 27668945 Click here to select all mutants from this PubMed ID in the graph
Abstract
Recent studies have revealed a variety of genes and mechanisms that influence the rate of aging progression. In this study, we identified cell cycle factors as potent regulators of health and longevity in

Temperature °C
20
Diet
NGM
Lifespan (days)
17.3
Lifespan change (compared to wild type)
-5.46%
Phenotype
The dramatic lifespan extension associated with knockdown of cdk-2 was not fully eliminated in daf-16(mgDf47) null mutants indicating that DAF-16 is central for the influence of cell cycle regulators on longevity.
Lifespan comparisons
Double mutant cdk-2(RNAi);daf-16(mgDf47) has a lifespan of 17.3 days, while single mutant cdk-2(RNAi) has a lifespan of 25.6 days, single mutant daf-16(mgDf47) has a lifespan of 15.9 days and wild type has a lifespan of 18.3 days.
Type of interaction
See methods
Opposite lifespan effects of single mutants
Citation
View abstract
Dottermusch M et al., 2016, Cell cycle controls stress response and longevity in C. elegans. Aging (Albany NY). 8(9):2100-2126 27668945 Click here to select all mutants from this PubMed ID in the graph
Abstract
Recent studies have revealed a variety of genes and mechanisms that influence the rate of aging progression. In this study, we identified cell cycle factors as potent regulators of health and longevity in

Temperature °C
20
Diet
NGM
Lifespan (days)
20.0
Lifespan change (compared to wild type)
3.63%
Phenotype
The dramatic lifespan extension associated with knockdown of cdk-2 was not fully eliminated in daf-16(mgDf47) null mutants indicating that DAF-16 is central for the influence of cell cycle regulators on longevity.
Lifespan comparisons
Double mutant cdk-2(RNAi);daf-16(mgDf47) has a lifespan of 20.0 days, while single mutant cdk-2(RNAi) has a lifespan of 22.7 days, single mutant daf-16(mgDf47) has a lifespan of 17.9 days and wild type has a lifespan of 19.3 days.
Type of interaction
See methods
Opposite lifespan effects of single mutants
Citation
View abstract
Dottermusch M et al., 2016, Cell cycle controls stress response and longevity in C. elegans. Aging (Albany NY). 8(9):2100-2126 27668945 Click here to select all mutants from this PubMed ID in the graph
Abstract
Recent studies have revealed a variety of genes and mechanisms that influence the rate of aging progression. In this study, we identified cell cycle factors as potent regulators of health and longevity in

Search genes: cdk-2 daf-16

Entrez ID
Symbol
GenAge
Wormbase ID

171911
cdk-2
View on GenAge (cdk-2)
WBGene00019362

Cyclin-Dependent Kinase family;Cyclin-dependent kinase 2

Locus: CELE_K03E5.3

Wormbase description: cdk-2 encodes the C. elegans ortholog of cyclin-dependent kinase 2; along with CYE-1 (cyclin E), CDK-2 is required for the G1/S transition in somatic cells, centrosome assembly and polarity establishment in the embryo, proliferation of germ cells, and suppression of terminal differentiation in quiescent cells after asymmetric division; CYE-1 and CDK-2 also regulate the germline mitosis/meiosis decision through post-translational regulation of GLD-1, likely direct phosphorylation.

Entrez ID
Symbol
GenAge
Wormbase ID

172981
daf-16
View on GenAge (daf-16)
WBGene00000912

Forkhead box protein O;hypothetical protein

Locus: CELE_R13H8.1

Wormbase description: daf-16 encodes the sole C. elegans forkhead box O (FOXO) homologue; DAF-16 functions as a transcription factor that acts in the insulin/IGF-1-mediated signaling (IIS) pathway that regulates dauer formation, longevity, fat metabolism, stress response, and innate immunity; DAF-16 regulates these various processes through isoform-specific expression, isoform-specific regulation by different AKT kinases, and differential regulation of target genes; DAF-16 can interact with the CBP-1 transcription cofactor in vitro, and interacts genetically with other genes in the insulin signaling and with daf-12, which encodes a nuclear hormone receptor; DAF-16 is activated in response to DNA damage during development and co-regulated by EGL-27, alleviates DNA-damage-induced developmental arrest by inducing DAF-16-associated element (DAE)-regulated genes; DAF-16 is broadly expressed but displays isoform-specific tissue enrichment; DAF-16 localizes to both the cytoplasm and the nucleus, with the ratio between the two an important regulator of function.

Orthologs of cdk-2;daf-16 in SynergyAge

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Species	Gene

Not in SynergyAge
Species	Gene

Orthologs of cdk-2 in SynergyAge

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Species	Gene

Orthologs of daf-16 in SynergyAge

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Species	Gene

Not in SynergyAge
Species	Gene
Mus musculus	Foxo6
Mus musculus	Foxo1
Mus musculus	Foxo4
Mus musculus	Foxo3