Lifespan changes: From wild type to cye-1;glp-1
20
NGM
24.5
26.94%
Knockdown of cye-1 by RNAi did not further extend the longevity of glp-1(e2141) mutant worms.
Double mutant cye-1(RNAi);glp-1(e2141) has a lifespan of 24.5 days, while single mutant cye-1(RNAi) has a lifespan of 25.8 days, single mutant glp-1(e2141) has a lifespan of 22.6 days and wild type has a lifespan of 19.3 days.
Dependent
Dottermusch M et al., 2016, Cell cycle controls stress response and longevity in C. elegans. Aging (Albany NY). 8(9):2100-2126 
27668945
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20
NGM
23.8
32.22%
Knockdown of cye-1 by RNAi did not further extend the longevity of glp-1(e2141) mutant worms.
Double mutant cye-1(RNAi);glp-1(e2141) has a lifespan of 23.8 days, while single mutant cye-1(RNAi) has a lifespan of 24.9 days, single mutant glp-1(e2141) has a lifespan of 22.9 days and wild type has a lifespan of 18.0 days.
Dependent
Dottermusch M et al., 2016, Cell cycle controls stress response and longevity in C. elegans. Aging (Albany NY). 8(9):2100-2126 27668945
Click here to select all mutants from this PubMed ID in the graph
20
NGM
26.1
33.85%
Knockdown of cye-1 by RNAi did not further extend the longevity of glp-1(e2141) mutant worms.
Double mutant cye-1(RNAi);glp-1(e2141) has a lifespan of 26.1 days, while single mutant cye-1(RNAi) has a lifespan of 27.0 days, single mutant glp-1(e2141) has a lifespan of 26.2 days and wild type has a lifespan of 19.5 days.
Antagonistic (positive)
Dottermusch M et al., 2016, Cell cycle controls stress response and longevity in C. elegans. Aging (Albany NY). 8(9):2100-2126 27668945
Click here to select all mutants from this PubMed ID in the graph
20
NGM
23.1
22.22%
Knockdown of cye-1 by RNAi did not further extend the longevity of glp-1(e2141) mutant worms.
Double mutant cye-1(RNAi);glp-1(e2141) has a lifespan of 23.1 days, while single mutant cye-1(RNAi) has a lifespan of 26.6 days, single mutant glp-1(e2141) has a lifespan of 23.4 days and wild type has a lifespan of 18.9 days.
Antagonistic (positive)
Dottermusch M et al., 2016, Cell cycle controls stress response and longevity in C. elegans. Aging (Albany NY). 8(9):2100-2126 27668945
Click here to select all mutants from this PubMed ID in the graph
G1/S-specific cyclin-E
Locus: CELE_C37A2.4
Wormbase description: cye-1 encodes the sole C. elegans E-type cyclin; CYE-1 is required for progression through the mitotic cell cycle during embryonic, larval, and germline development; cye-1 is also required for endoreduplication in intestinal cells; CYE-1 is expressed ubiquitously in nuclei during embryonic development and postembryonically in proliferating blast cells, including germline stem cells; in the germline, CYE-1 levels are negatively regulated in meiotic cells by a CUL-1, SKR-1/2, PROM-1 SCF ubiquitin ligase.
Protein glp-1
Locus: CELE_F02A9.6
Wormbase description: glp-1 encodes an N-glycosylated transmembrane protein that, along with LIN-12, comprises one of two C. elegans members of the LIN-12/Notch family of receptors; from the N- to the C-terminus, GLP-1 is characterized by ten extracellular EGF-like repeats, three LIN-12/Notch repeats, a CC-linker, a transmembrane domain, a RAM domain, six intracellular ankyrin repeats, and a PEST sequence; in C. elegans, GLP-1 activity is required for cell fate specification in germline and somatic tissues; in the germline, GLP-1, acting as a receptor for the DSL family ligand LAG-2, is essential for mitotic proliferation of germ cells and maintenance of germline stem cells; in somatic tissues, maternally provided GLP-1, acting as a receptor for the DSL family ligand APX-1, is required for inductive interactions that specify the fates of certain embryonic blastomeres; GLP-1 is also required for some later embryonic cell fate decisions, and in these decisions its activity is functionally redundant with that of LIN-12; GLP-1 expression is regulated temporally and spatially via translational control, as GLP-1 mRNA, present ubiquitously in the germline and embryo, yields detectable protein solely in lateral, interior, and endomembranes of distal, mitotic germ cells, and then predominantly in the AB blastomere and its descendants in the early embryo; proper spatial translation of glp-1 mRNA in the embryo is dependent upon genes such as the par genes, that are required for normal anterior-posterior asymmetry in the early embryo; signaling through GLP-1 controls the activity of the downstream Notch pathway components LAG-3 and LAG-1, the latter being predicted to function as part of a transcriptional feedback mechanism that positively regulates GLP-1 expression; signaling through the DNA-binding protein LAG-1 is believed to involve a direct interaction between LAG-1 and the GLP-1 RAM and ankyrin domains
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SynergyAge database hosts high-quality, manually curated information about the synergistic and antagonistic lifespan effects of genetic interventions in model organisms, also allowing users to explore the longevity relationships between genes in a visual way.
If you would like to cite this database please use:
Bunu, G., Toren, D., Ion, C. et al. SynergyAge, a curated database for synergistic and antagonistic interactions of longevity-associated genes. Sci Data 7, 366 (2020). https://doi.org/10.1038/s41597-020-00710-z
Group webpage: www.aging-research.group
