cdk-2;glp-1

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Genetic mutants with cdk-2, glp-1 alterations

Names of genes are ordered alphabetically. For the order of interventions, please see the specific paper.

Temperature °C
20
Diet
NGM
Lifespan (days)
23.4
Lifespan change (compared to wild type)
22.51%
Phenotype
cdk-2(RNAi) has no effect on longevity of germless glp-1(e2141) mutants.
Lifespan comparisons
Double mutant cdk-2(RNAi);glp-1(e2141) has a lifespan of 23.4 days, while single mutant cdk-2(RNAi) has a lifespan of 25.6 days, single mutant glp-1(e2141) has a lifespan of 23.0 days and wild type has a lifespan of 19.1 days.
Type of interaction
See methods
Dependent
Citation
View abstract
Dottermusch M et al., 2016, Cell cycle controls stress response and longevity in C. elegans. Aging (Albany NY). 8(9):2100-2126 27668945 Click here to select all mutants from this PubMed ID in the graph
Abstract
Recent studies have revealed a variety of genes and mechanisms that influence the rate of aging progression. In this study, we identified cell cycle factors as potent regulators of health and longevity in

Temperature °C
20
Diet
NGM
Lifespan (days)
23.7
Lifespan change (compared to wild type)
25.40%
Phenotype
cdk-2(RNAi) has no effect on longevity of germless glp-1(e2141) mutants.
Lifespan comparisons
Double mutant cdk-2(RNAi);glp-1(e2141) has a lifespan of 23.7 days, while single mutant cdk-2(RNAi) has a lifespan of 26.1 days, single mutant glp-1(e2141) has a lifespan of 23.4 days and wild type has a lifespan of 18.9 days.
Type of interaction
See methods
Dependent
Citation
View abstract
Dottermusch M et al., 2016, Cell cycle controls stress response and longevity in C. elegans. Aging (Albany NY). 8(9):2100-2126 27668945 Click here to select all mutants from this PubMed ID in the graph
Abstract
Recent studies have revealed a variety of genes and mechanisms that influence the rate of aging progression. In this study, we identified cell cycle factors as potent regulators of health and longevity in

Temperature °C
20
Diet
NGM
Lifespan (days)
23.1
Lifespan change (compared to wild type)
19.69%
Phenotype
cdk-2(RNAi) has no effect on longevity of germless glp-1(e2141) mutants.
Lifespan comparisons
Double mutant cdk-2(RNAi);glp-1(e2141) has a lifespan of 23.1 days, while single mutant cdk-2(RNAi) has a lifespan of 25.3 days, single mutant glp-1(e2141) has a lifespan of 22.6 days and wild type has a lifespan of 19.3 days.
Type of interaction
See methods
Dependent
Citation
View abstract
Dottermusch M et al., 2016, Cell cycle controls stress response and longevity in C. elegans. Aging (Albany NY). 8(9):2100-2126 27668945 Click here to select all mutants from this PubMed ID in the graph
Abstract
Recent studies have revealed a variety of genes and mechanisms that influence the rate of aging progression. In this study, we identified cell cycle factors as potent regulators of health and longevity in

Search genes: cdk-2 glp-1

Entrez ID
Symbol
GenAge
Wormbase ID

171911
cdk-2
View on GenAge (cdk-2)
WBGene00019362

Cyclin-Dependent Kinase family;Cyclin-dependent kinase 2

Locus: CELE_K03E5.3

Wormbase description: cdk-2 encodes the C. elegans ortholog of cyclin-dependent kinase 2; along with CYE-1 (cyclin E), CDK-2 is required for the G1/S transition in somatic cells, centrosome assembly and polarity establishment in the embryo, proliferation of germ cells, and suppression of terminal differentiation in quiescent cells after asymmetric division; CYE-1 and CDK-2 also regulate the germline mitosis/meiosis decision through post-translational regulation of GLD-1, likely direct phosphorylation.

Entrez ID
Symbol
GenAge
Wormbase ID

176286
glp-1
View on GenAge (glp-1)
WBGene00001609

Protein glp-1

Locus: CELE_F02A9.6

Wormbase description: glp-1 encodes an N-glycosylated transmembrane protein that, along with LIN-12, comprises one of two C. elegans members of the LIN-12/Notch family of receptors; from the N- to the C-terminus, GLP-1 is characterized by ten extracellular EGF-like repeats, three LIN-12/Notch repeats, a CC-linker, a transmembrane domain, a RAM domain, six intracellular ankyrin repeats, and a PEST sequence; in C. elegans, GLP-1 activity is required for cell fate specification in germline and somatic tissues; in the germline, GLP-1, acting as a receptor for the DSL family ligand LAG-2, is essential for mitotic proliferation of germ cells and maintenance of germline stem cells; in somatic tissues, maternally provided GLP-1, acting as a receptor for the DSL family ligand APX-1, is required for inductive interactions that specify the fates of certain embryonic blastomeres; GLP-1 is also required for some later embryonic cell fate decisions, and in these decisions its activity is functionally redundant with that of LIN-12; GLP-1 expression is regulated temporally and spatially via translational control, as GLP-1 mRNA, present ubiquitously in the germline and embryo, yields detectable protein solely in lateral, interior, and endomembranes of distal, mitotic germ cells, and then predominantly in the AB blastomere and its descendants in the early embryo; proper spatial translation of glp-1 mRNA in the embryo is dependent upon genes such as the par genes, that are required for normal anterior-posterior asymmetry in the early embryo; signaling through GLP-1 controls the activity of the downstream Notch pathway components LAG-3 and LAG-1, the latter being predicted to function as part of a transcriptional feedback mechanism that positively regulates GLP-1 expression; signaling through the DNA-binding protein LAG-1 is believed to involve a direct interaction between LAG-1 and the GLP-1 RAM and ankyrin domains

Orthologs of cdk-2;glp-1 in SynergyAge

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Orthologs of cdk-2 in SynergyAge

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Orthologs of glp-1 in SynergyAge

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