cye-1;mes-1

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Genetic mutants with cye-1, mes-1 alterations

Names of genes are ordered alphabetically. For the order of interventions, please see the specific paper.

Temperature °C
20
Diet
NGM
Lifespan (days)
22.1
Lifespan change (compared to wild type)
19.46%
Phenotype
Knockdown of cye-1(RNAi) was able to extend the lifespan of fertile mes-1(bn7) worms (21%).
Lifespan comparisons
Double mutant cye-1(RNAi);mes-1(bn7) has a lifespan of 22.1 days, while single mutant cye-1(RNAi) has a lifespan of 23.4 days, single mutant mes-1(bn7) has a lifespan of 18.1 days and wild type has a lifespan of 18.5 days.
Type of interaction
See methods
Opposite lifespan effects of single mutants
Citation
View abstract
Dottermusch M et al., 2016, Cell cycle controls stress response and longevity in C. elegans. Aging (Albany NY). 8(9):2100-2126 27668945 Click here to select all mutants from this PubMed ID in the graph
Abstract
Recent studies have revealed a variety of genes and mechanisms that influence the rate of aging progression. In this study, we identified cell cycle factors as potent regulators of health and longevity in

Temperature °C
20
Diet
NGM
Lifespan (days)
23.7
Lifespan change (compared to wild type)
25.40%
Phenotype
Knockdown of cye-1(RNAi) was not able to extend the lifespan of sterile mes-1(bn7) animals.
Lifespan comparisons
Double mutant cye-1(RNAi);mes-1(bn7) has a lifespan of 23.7 days, while single mutant cye-1(RNAi) has a lifespan of 24.2 days, single mutant mes-1(bn7) has a lifespan of 24.2 days and wild type has a lifespan of 18.9 days.
Type of interaction
See methods
Antagonistic (positive)
Citation
View abstract
Dottermusch M et al., 2016, Cell cycle controls stress response and longevity in C. elegans. Aging (Albany NY). 8(9):2100-2126 27668945 Click here to select all mutants from this PubMed ID in the graph
Abstract
Recent studies have revealed a variety of genes and mechanisms that influence the rate of aging progression. In this study, we identified cell cycle factors as potent regulators of health and longevity in

Temperature °C
20
Diet
NGM
Lifespan (days)
22.0
Lifespan change (compared to wild type)
13.99%
Phenotype
Knockdown of cye-1(RNAi) was able to extend the lifespan of fertile mes-1(bn7) worms (21%).
Lifespan comparisons
Double mutant cye-1(RNAi);mes-1(bn7) has a lifespan of 22.0 days, while single mutant cye-1(RNAi) has a lifespan of 25.2 days, single mutant mes-1(bn7) has a lifespan of 18.4 days and wild type has a lifespan of 19.3 days.
Type of interaction
See methods
Opposite lifespan effects of single mutants
Citation
View abstract
Dottermusch M et al., 2016, Cell cycle controls stress response and longevity in C. elegans. Aging (Albany NY). 8(9):2100-2126 27668945 Click here to select all mutants from this PubMed ID in the graph
Abstract
Recent studies have revealed a variety of genes and mechanisms that influence the rate of aging progression. In this study, we identified cell cycle factors as potent regulators of health and longevity in

Temperature °C
20
Diet
NGM
Lifespan (days)
24.3
Lifespan change (compared to wild type)
25.91%
Phenotype
Knockdown of cye-1(RNAi) was not able to extend the lifespan of sterile mes-1(bn7) animals.
Lifespan comparisons
Double mutant cye-1(RNAi);mes-1(bn7) has a lifespan of 24.3 days, while single mutant cye-1(RNAi) has a lifespan of 25.2 days, single mutant mes-1(bn7) has a lifespan of 24.5 days and wild type has a lifespan of 19.3 days.
Type of interaction
See methods
Antagonistic (positive)
Citation
View abstract
Dottermusch M et al., 2016, Cell cycle controls stress response and longevity in C. elegans. Aging (Albany NY). 8(9):2100-2126 27668945 Click here to select all mutants from this PubMed ID in the graph
Abstract
Recent studies have revealed a variety of genes and mechanisms that influence the rate of aging progression. In this study, we identified cell cycle factors as potent regulators of health and longevity in

Temperature °C
20
Diet
NGM
Lifespan (days)
23.1
Lifespan change (compared to wild type)
24.86%
Phenotype
Knockdown of cye-1(RNAi) was not able to extend the lifespan of sterile mes-1(bn7) animals.
Lifespan comparisons
Double mutant cye-1(RNAi);mes-1(bn7) has a lifespan of 23.1 days, while single mutant cye-1(RNAi) has a lifespan of 23.4 days, single mutant mes-1(bn7) has a lifespan of 23.9 days and wild type has a lifespan of 18.5 days.
Type of interaction
See methods
Antagonistic (positive)
Citation
View abstract
Dottermusch M et al., 2016, Cell cycle controls stress response and longevity in C. elegans. Aging (Albany NY). 8(9):2100-2126 27668945 Click here to select all mutants from this PubMed ID in the graph
Abstract
Recent studies have revealed a variety of genes and mechanisms that influence the rate of aging progression. In this study, we identified cell cycle factors as potent regulators of health and longevity in

Search genes: cye-1 mes-1

Entrez ID
Symbol
GenAge
Wormbase ID

172399
cye-1
View on GenAge (cye-1)
WBGene00000871

G1/S-specific cyclin-E

Locus: CELE_C37A2.4

Wormbase description: cye-1 encodes the sole C. elegans E-type cyclin; CYE-1 is required for progression through the mitotic cell cycle during embryonic, larval, and germline development; cye-1 is also required for endoreduplication in intestinal cells; CYE-1 is expressed ubiquitously in nuclei during embryonic development and postembryonically in proliferating blast cells, including germline stem cells; in the germline, CYE-1 levels are negatively regulated in meiotic cells by a CUL-1, SKR-1/2, PROM-1 SCF ubiquitin ligase.

Entrez ID
Symbol
GenAge
Wormbase ID

181362
mes-1
View on GenAge (mes-1)
WBGene00003219

Protein mes-1

Locus: CELE_F54F7.5

Wormbase description: The mes-1 gene encodes a receptor tyrosine kinase-like protein that is required for unequal cell divisions in the early embryonic germline; during embryonic cell divisions, mes-1 is involved in positioning of the early mitotic spindle and of associated P granules.

Orthologs of cye-1;mes-1 in SynergyAge

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Species	Gene

Not in SynergyAge
Species	Gene

Orthologs of cye-1 in SynergyAge

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Species	Gene

Not in SynergyAge
Species	Gene
Drosophila melanogaster	CycE
Mus musculus	Ccne1
Mus musculus	Ccne2

Orthologs of mes-1 in SynergyAge

Show in SynergyAge
Species	Gene