cye-1;daf-12

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Genetic mutants with cye-1, daf-12 alterations

Names of genes are ordered alphabetically. For the order of interventions, please see the specific paper.

Temperature °C
20
Diet
NGM
Lifespan (days)
19.3
Lifespan change (compared to wild type)
-3.02%
Phenotype
daf-12(rh61rh411);cye-1(RNAi) animals have significantly shortened lifespans compared with cye-1(RNAi).
Lifespan comparisons
Double mutant cye-1(RNAi);daf-12(rh61rh411) has a lifespan of 19.3 days, while single mutant cye-1(RNAi) has a lifespan of 24.0 days, single mutant daf-12(rh61rh411) has a lifespan of 17.6 days and wild type has a lifespan of 19.9 days.
Type of interaction
See methods
Opposite lifespan effects of single mutants
Citation
View abstract
Dottermusch M et al., 2016, Cell cycle controls stress response and longevity in C. elegans. Aging (Albany NY). 8(9):2100-2126 27668945 Click here to select all mutants from this PubMed ID in the graph
Abstract
Recent studies have revealed a variety of genes and mechanisms that influence the rate of aging progression. In this study, we identified cell cycle factors as potent regulators of health and longevity in

Temperature °C
20
Diet
NGM
Lifespan (days)
19.5
Lifespan change (compared to wild type)
-4.41%
Phenotype
daf-12(rh61rh411);cye-1(RNAi) animals have significantly shortened lifespans compared with cye-1(RNAi).
Lifespan comparisons
Double mutant cye-1(RNAi);daf-12(rh61rh411) has a lifespan of 19.5 days, while single mutant cye-1(RNAi) has a lifespan of 24.3 days, single mutant daf-12(rh61rh411) has a lifespan of 18.0 days and wild type has a lifespan of 20.4 days.
Type of interaction
See methods
Opposite lifespan effects of single mutants
Citation
View abstract
Dottermusch M et al., 2016, Cell cycle controls stress response and longevity in C. elegans. Aging (Albany NY). 8(9):2100-2126 27668945 Click here to select all mutants from this PubMed ID in the graph
Abstract
Recent studies have revealed a variety of genes and mechanisms that influence the rate of aging progression. In this study, we identified cell cycle factors as potent regulators of health and longevity in

Temperature °C
20
Diet
NGM
Lifespan (days)
19.0
Lifespan change (compared to wild type)
-1.55%
Phenotype
daf-12(rh61rh411);cye-1(RNAi) animals have significantly shortened lifespans compared with cye-1(RNAi).
Lifespan comparisons
Double mutant cye-1(RNAi);daf-12(rh61rh411) has a lifespan of 19.0 days, while single mutant cye-1(RNAi) has a lifespan of 23.6 days, single mutant daf-12(rh61rh411) has a lifespan of 17.2 days and wild type has a lifespan of 19.3 days.
Type of interaction
See methods
Opposite lifespan effects of single mutants
Citation
View abstract
Dottermusch M et al., 2016, Cell cycle controls stress response and longevity in C. elegans. Aging (Albany NY). 8(9):2100-2126 27668945 Click here to select all mutants from this PubMed ID in the graph
Abstract
Recent studies have revealed a variety of genes and mechanisms that influence the rate of aging progression. In this study, we identified cell cycle factors as potent regulators of health and longevity in

Search genes: cye-1 daf-12

Entrez ID
Symbol
GenAge
Wormbase ID

172399
cye-1
View on GenAge (cye-1)
WBGene00000871

G1/S-specific cyclin-E

Locus: CELE_C37A2.4

Wormbase description: cye-1 encodes the sole C. elegans E-type cyclin; CYE-1 is required for progression through the mitotic cell cycle during embryonic, larval, and germline development; cye-1 is also required for endoreduplication in intestinal cells; CYE-1 is expressed ubiquitously in nuclei during embryonic development and postembryonically in proliferating blast cells, including germline stem cells; in the germline, CYE-1 levels are negatively regulated in meiotic cells by a CUL-1, SKR-1/2, PROM-1 SCF ubiquitin ligase.

Entrez ID
Symbol
GenAge
Wormbase ID

181263
daf-12
View on GenAge (daf-12)
WBGene00000908

Nuclear hormone receptor family member daf-12

Locus: CELE_F11A1.3

Wormbase description: daf-12 encodes a member of the steroid hormone receptor superfamily that is homologous to human VITAMIN D RECEPTOR (VDR; OMIM:601769, mutated in vitamin D-resistant rickets); daf-12 affects dauer formation downstream of the TGF- and insulin signaling pathways, and affects gonad-dependent adult longevity together with DAF-16, chemosensory signal transduction, and distal tip cell migration and hypodermal and intestinal cell lineages during the L3 larval stage; DAF-12 is expressed in the nucleus and in most cells; daf-12 expression in lateral seam cells is negatively regulated by the let-7 miRNA.

Orthologs of cye-1;daf-12 in SynergyAge

Show in SynergyAge
Species	Gene

Not in SynergyAge
Species	Gene
Drosophila melanogaster	CycE;Hr96

Orthologs of cye-1 in SynergyAge

Show in SynergyAge
Species	Gene

Not in SynergyAge
Species	Gene
Drosophila melanogaster	CycE
Mus musculus	Ccne1
Mus musculus	Ccne2

Orthologs of daf-12 in SynergyAge

Show in SynergyAge
Species	Gene

Not in SynergyAge
Species	Gene
Drosophila melanogaster	Hr96