cye-1;daf-9

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Genetic mutants with cye-1, daf-9 alterations

Names of genes are ordered alphabetically. For the order of interventions, please see the specific paper.

Temperature °C
20
Diet
NGM
Lifespan (days)
19.7
Lifespan change (compared to wild type)
-1.01%
Phenotype
The lifespan extension of cye-1(RNAi) was strongly suppressed in the daf-9(rh50) mutant background.
Lifespan comparisons
Double mutant cye-1(RNAi);daf-9(rh50) has a lifespan of 19.7 days, while single mutant cye-1(RNAi) has a lifespan of 24.0 days, single mutant daf-9(rh50) has a lifespan of 18.5 days and wild type has a lifespan of 19.9 days.
Type of interaction
See methods
Opposite lifespan effects of single mutants
Citation
View abstract
Dottermusch M et al., 2016, Cell cycle controls stress response and longevity in C. elegans. Aging (Albany NY). 8(9):2100-2126 27668945 Click here to select all mutants from this PubMed ID in the graph
Abstract
Recent studies have revealed a variety of genes and mechanisms that influence the rate of aging progression. In this study, we identified cell cycle factors as potent regulators of health and longevity in

Temperature °C
20
Diet
NGM
Lifespan (days)
19.5
Lifespan change (compared to wild type)
-4.41%
Phenotype
The lifespan extension of cye-1(RNAi) was strongly suppressed in the daf-9(rh50) mutant background.
Lifespan comparisons
Double mutant cye-1(RNAi);daf-9(rh50) has a lifespan of 19.5 days, while single mutant cye-1(RNAi) has a lifespan of 24.3 days, single mutant daf-9(rh50) has a lifespan of 18.3 days and wild type has a lifespan of 20.4 days.
Type of interaction
See methods
Opposite lifespan effects of single mutants
Citation
View abstract
Dottermusch M et al., 2016, Cell cycle controls stress response and longevity in C. elegans. Aging (Albany NY). 8(9):2100-2126 27668945 Click here to select all mutants from this PubMed ID in the graph
Abstract
Recent studies have revealed a variety of genes and mechanisms that influence the rate of aging progression. In this study, we identified cell cycle factors as potent regulators of health and longevity in

Temperature °C
20
Diet
NGM
Lifespan (days)
19.9
Lifespan change (compared to wild type)
3.11%
Phenotype
The lifespan extension of cye-1(RNAi) was strongly suppressed in the daf-9(rh50) mutant background.
Lifespan comparisons
Double mutant cye-1(RNAi);daf-9(rh50) has a lifespan of 19.9 days, while single mutant cye-1(RNAi) has a lifespan of 23.6 days, single mutant daf-9(rh50) has a lifespan of 18.8 days and wild type has a lifespan of 19.3 days.
Type of interaction
See methods
Opposite lifespan effects of single mutants
Citation
View abstract
Dottermusch M et al., 2016, Cell cycle controls stress response and longevity in C. elegans. Aging (Albany NY). 8(9):2100-2126 27668945 Click here to select all mutants from this PubMed ID in the graph
Abstract
Recent studies have revealed a variety of genes and mechanisms that influence the rate of aging progression. In this study, we identified cell cycle factors as potent regulators of health and longevity in

Search genes: cye-1 daf-9

Entrez ID
Symbol
GenAge
Wormbase ID

172399
cye-1
View on GenAge (cye-1)
WBGene00000871

G1/S-specific cyclin-E

Locus: CELE_C37A2.4

Wormbase description: cye-1 encodes the sole C. elegans E-type cyclin; CYE-1 is required for progression through the mitotic cell cycle during embryonic, larval, and germline development; cye-1 is also required for endoreduplication in intestinal cells; CYE-1 is expressed ubiquitously in nuclei during embryonic development and postembryonically in proliferating blast cells, including germline stem cells; in the germline, CYE-1 levels are negatively regulated in meiotic cells by a CUL-1, SKR-1/2, PROM-1 SCF ubiquitin ligase.

Entrez ID
Symbol
GenAge
Wormbase ID

180889
daf-9
View on GenAge (daf-9)
WBGene00000905

Cytochrome P450 daf-9

Locus: CELE_T13C5.1

Wormbase description: daf-9 encodes a cytochrome P450 of the CYP2 subfamily that by homology is predicted to function as a steroidogenic or fatty acid hydroxylase; DAF-9 likely functions cell nonautonomously in hypodermal and neuronal cells to produce, for the DAF-12 nuclear receptor, a lipophilic hormone whose presence is necessary for bypassing entry into the alternative L3/dauer larval stage and promoting reproductive development; in regulating dauer formation, daf-9 acts downstream of the DAF-2/insulin/IGF receptor and the DAF-7/TGFbeta ligand, suggesting that at least two of the signaling pathways that control dauer formation converge, in part, upon daf-9; in addition, daf-9 activity is required for gonadal cell migration; a DAF-9::GFP fusion is expressed in the XXXL/R head cells at all developmental stages, in hypodermal cells from the L2 to L4 larval stages, and in the spermatheca of adult hermaphrodites.

Orthologs of cye-1;daf-9 in SynergyAge

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Species	Gene

Not in SynergyAge
Species	Gene

Orthologs of cye-1 in SynergyAge

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Species	Gene

Not in SynergyAge
Species	Gene
Drosophila melanogaster	CycE
Mus musculus	Ccne1
Mus musculus	Ccne2

Orthologs of daf-9 in SynergyAge

Show in SynergyAge
Species	Gene