Lifespan changes: From wild type to cye-1;kri-1
20
NGM
21.0
8.25%
The longevity associated with cye-1(RNAi) was strongly suppressed by lack of kri-1(ok1251), shortening mean lifespan by up to 18%.
Double mutant cye-1(RNAi);kri-1(ok1251) has a lifespan of 21.0 days, while single mutant cye-1(RNAi) has a lifespan of 25.5 days, single mutant kri-1(ok1251) has a lifespan of 19.0 days and wild type has a lifespan of 19.4 days.
Opposite lifespan effects of single mutants
Dottermusch M et al., 2016, Cell cycle controls stress response and longevity in C. elegans. Aging (Albany NY). 8(9):2100-2126 
27668945
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20
NGM
22.5
11.94%
The longevity associated with cye-1(RNAi) was strongly suppressed by lack of kri-1(ok1251), shortening mean lifespan.
Double mutant cye-1(RNAi);kri-1(ok1251) has a lifespan of 22.5 days, while single mutant cye-1(RNAi) has a lifespan of 27.1 days, single mutant kri-1(ok1251) has a lifespan of 19.7 days and wild type has a lifespan of 20.1 days.
Opposite lifespan effects of single mutants
Dottermusch M et al., 2016, Cell cycle controls stress response and longevity in C. elegans. Aging (Albany NY). 8(9):2100-2126 27668945
Click here to select all mutants from this PubMed ID in the graph
20
NGM
19.4
3.19%
The longevity associated with cye-1(RNAi) was strongly suppressed by lack of kri-1(ok1251), shortening mean lifespan.
Double mutant cye-1(RNAi);kri-1(ok1251) has a lifespan of 19.4 days, while single mutant cye-1(RNAi) has a lifespan of 24.4 days, single mutant kri-1(ok1251) has a lifespan of 18.1 days and wild type has a lifespan of 18.8 days.
Opposite lifespan effects of single mutants
Dottermusch M et al., 2016, Cell cycle controls stress response and longevity in C. elegans. Aging (Albany NY). 8(9):2100-2126 27668945
Click here to select all mutants from this PubMed ID in the graph
G1/S-specific cyclin-E
Locus: CELE_C37A2.4
Wormbase description: cye-1 encodes the sole C. elegans E-type cyclin; CYE-1 is required for progression through the mitotic cell cycle during embryonic, larval, and germline development; cye-1 is also required for endoreduplication in intestinal cells; CYE-1 is expressed ubiquitously in nuclei during embryonic development and postembryonically in proliferating blast cells, including germline stem cells; in the germline, CYE-1 levels are negatively regulated in meiotic cells by a CUL-1, SKR-1/2, PROM-1 SCF ubiquitin ligase.
human KRIT 1 (Krev interaction trapped/cerebral cavernous malformation 1) homolog
Locus: CELE_ZK265.1
Wormbase description: kri-1 encodes an ankyrin repeat and FERM domain-containing protein orthologous to human KRIT1 (Krev interaction trapped/cerebral cavernous malformation 1, OMIM:604214); kri-1 was identified in RNAi screens for genes required for DAF-16-dependent lifespan extension in germline-depleted animals; subsequent analysis of kri-1 mutations suggests that KRI-1 is required for proper localization of DAF-16 in the intestine in response to germline loss; a rescuing KRI-1::GFP construct is expressed in larval and adult stages in pharyngeal and intestinal cells; the KRI-1::GFP is generally diffuse, but also localizes to apical and apicolateral cell surfaces as well as to intestinal nuclei in some animals.
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SynergyAge database hosts high-quality, manually curated information about the synergistic and antagonistic lifespan effects of genetic interventions in model organisms, also allowing users to explore the longevity relationships between genes in a visual way.
If you would like to cite this database please use:
Bunu, G., Toren, D., Ion, C. et al. SynergyAge, a curated database for synergistic and antagonistic interactions of longevity-associated genes. Sci Data 7, 366 (2020). https://doi.org/10.1038/s41597-020-00710-z
Group webpage: www.aging-research.group
