cdk-2;kri-1

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Genetic mutants with cdk-2, kri-1 alterations

Names of genes are ordered alphabetically. For the order of interventions, please see the specific paper.

Temperature °C
20
Diet
NGM
Lifespan (days)
21.0
Lifespan change (compared to wild type)
8.25%
Phenotype
KRI-1 contributes to cdk-2(RNAi) longevity. Survival of cdk-2(RNAi) worms was substantially reduced by kri-1(ok1251) mutation.
Lifespan comparisons
Double mutant cdk-2(RNAi);kri-1(ok1251) has a lifespan of 21.0 days, while single mutant cdk-2(RNAi) has a lifespan of 24.6 days, single mutant kri-1(ok1251) has a lifespan of 19.0 days and wild type has a lifespan of 19.4 days.
Type of interaction
See methods
Opposite lifespan effects of single mutants
Citation
View abstract
Dottermusch M et al., 2016, Cell cycle controls stress response and longevity in C. elegans. Aging (Albany NY). 8(9):2100-2126 27668945 Click here to select all mutants from this PubMed ID in the graph
Abstract
Recent studies have revealed a variety of genes and mechanisms that influence the rate of aging progression. In this study, we identified cell cycle factors as potent regulators of health and longevity in

Temperature °C
20
Diet
NGM
Lifespan (days)
22.6
Lifespan change (compared to wild type)
12.44%
Phenotype
KRI-1 contributes to cdk-2(RNAi) longevity. Survival of cdk-2(RNAi) worms was substantially reduced by kri-1(ok1251) mutation.
Lifespan comparisons
Double mutant cdk-2(RNAi);kri-1(ok1251) has a lifespan of 22.6 days, while single mutant cdk-2(RNAi) has a lifespan of 26.3 days, single mutant kri-1(ok1251) has a lifespan of 19.7 days and wild type has a lifespan of 20.1 days.
Type of interaction
See methods
Opposite lifespan effects of single mutants
Citation
View abstract
Dottermusch M et al., 2016, Cell cycle controls stress response and longevity in C. elegans. Aging (Albany NY). 8(9):2100-2126 27668945 Click here to select all mutants from this PubMed ID in the graph
Abstract
Recent studies have revealed a variety of genes and mechanisms that influence the rate of aging progression. In this study, we identified cell cycle factors as potent regulators of health and longevity in

Temperature °C
20
Diet
NGM
Lifespan (days)
19.0
Lifespan change (compared to wild type)
1.06%
Phenotype
KRI-1 contributes to cdk-2(RNAi) longevity. Survival of cdk-2(RNAi) worms was substantially reduced by kri-1(ok1251) mutation.
Lifespan comparisons
Double mutant cdk-2(RNAi);kri-1(ok1251) has a lifespan of 19.0 days, while single mutant cdk-2(RNAi) has a lifespan of 23.3 days, single mutant kri-1(ok1251) has a lifespan of 18.1 days and wild type has a lifespan of 18.8 days.
Type of interaction
See methods
Opposite lifespan effects of single mutants
Citation
View abstract
Dottermusch M et al., 2016, Cell cycle controls stress response and longevity in C. elegans. Aging (Albany NY). 8(9):2100-2126 27668945 Click here to select all mutants from this PubMed ID in the graph
Abstract
Recent studies have revealed a variety of genes and mechanisms that influence the rate of aging progression. In this study, we identified cell cycle factors as potent regulators of health and longevity in

Search genes: cdk-2 kri-1

Entrez ID
Symbol
GenAge
Wormbase ID

171911
cdk-2
View on GenAge (cdk-2)
WBGene00019362

Cyclin-Dependent Kinase family;Cyclin-dependent kinase 2

Locus: CELE_K03E5.3

Wormbase description: cdk-2 encodes the C. elegans ortholog of cyclin-dependent kinase 2; along with CYE-1 (cyclin E), CDK-2 is required for the G1/S transition in somatic cells, centrosome assembly and polarity establishment in the embryo, proliferation of germ cells, and suppression of terminal differentiation in quiescent cells after asymmetric division; CYE-1 and CDK-2 also regulate the germline mitosis/meiosis decision through post-translational regulation of GLD-1, likely direct phosphorylation.

Entrez ID
Symbol
GenAge
Wormbase ID

191275
kri-1
View on GenAge (kri-1)
WBGene00013955

human KRIT 1 (Krev interaction trapped/cerebral cavernous malformation 1) homolog

Locus: CELE_ZK265.1

Wormbase description: kri-1 encodes an ankyrin repeat and FERM domain-containing protein orthologous to human KRIT1 (Krev interaction trapped/cerebral cavernous malformation 1, OMIM:604214); kri-1 was identified in RNAi screens for genes required for DAF-16-dependent lifespan extension in germline-depleted animals; subsequent analysis of kri-1 mutations suggests that KRI-1 is required for proper localization of DAF-16 in the intestine in response to germline loss; a rescuing KRI-1::GFP construct is expressed in larval and adult stages in pharyngeal and intestinal cells; the KRI-1::GFP is generally diffuse, but also localizes to apical and apicolateral cell surfaces as well as to intestinal nuclei in some animals.

Orthologs of cdk-2;kri-1 in SynergyAge

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Species	Gene

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Species	Gene

Orthologs of cdk-2 in SynergyAge

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Species	Gene

Orthologs of kri-1 in SynergyAge

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Species	Gene

Not in SynergyAge
Species	Gene
Mus musculus	Krit1