cye-1;rrf-1

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Genetic mutants with cye-1, rrf-1 alterations

Names of genes are ordered alphabetically. For the order of interventions, please see the specific paper.

Temperature °C
20
Diet
NGM
Lifespan (days)
22.9
Lifespan change (compared to wild type)
19.90%
Phenotype
cye-1(RNAi) increases lifespan in rrf-1(pk1417) mutants to a similar extend as in wild type worms (18% compared to 24%, respectively).
Lifespan comparisons
Double mutant cye-1(RNAi);rrf-1(pk1417) has a lifespan of 22.9 days, while single mutant cye-1(RNAi) has a lifespan of 23.6 days, single mutant rrf-1(pk1417) has a lifespan of 19.4 days and wild type has a lifespan of 19.1 days.
Type of interaction
See methods
Dependent
Citation
View abstract
Dottermusch M et al., 2016, Cell cycle controls stress response and longevity in C. elegans. Aging (Albany NY). 8(9):2100-2126 27668945 Click here to select all mutants from this PubMed ID in the graph
Abstract
Recent studies have revealed a variety of genes and mechanisms that influence the rate of aging progression. In this study, we identified cell cycle factors as potent regulators of health and longevity in

Temperature °C
20
Diet
NGM
Lifespan (days)
23.7
Lifespan change (compared to wild type)
24.74%
Phenotype
cye-1(RNAi) increases lifespan in rrf-1(pk1417) mutants to a similar extend as in wild type worms.
Lifespan comparisons
Double mutant cye-1(RNAi);rrf-1(pk1417) has a lifespan of 23.7 days, while single mutant cye-1(RNAi) has a lifespan of 24.2 days, single mutant rrf-1(pk1417) has a lifespan of 19.1 days and wild type has a lifespan of 19.0 days.
Type of interaction
See methods
Dependent
Citation
View abstract
Dottermusch M et al., 2016, Cell cycle controls stress response and longevity in C. elegans. Aging (Albany NY). 8(9):2100-2126 27668945 Click here to select all mutants from this PubMed ID in the graph
Abstract
Recent studies have revealed a variety of genes and mechanisms that influence the rate of aging progression. In this study, we identified cell cycle factors as potent regulators of health and longevity in

Temperature °C
20
Diet
NGM
Lifespan (days)
22.1
Lifespan change (compared to wild type)
15.71%
Phenotype
cye-1(RNAi) increases lifespan in rrf-1(pk1417) mutants to a similar extend as in wild type worms.
Lifespan comparisons
Double mutant cye-1(RNAi);rrf-1(pk1417) has a lifespan of 22.1 days, while single mutant cye-1(RNAi) has a lifespan of 23.1 days, single mutant rrf-1(pk1417) has a lifespan of 19.8 days and wild type has a lifespan of 19.1 days.
Type of interaction
See methods
Dependent
Citation
View abstract
Dottermusch M et al., 2016, Cell cycle controls stress response and longevity in C. elegans. Aging (Albany NY). 8(9):2100-2126 27668945 Click here to select all mutants from this PubMed ID in the graph
Abstract
Recent studies have revealed a variety of genes and mechanisms that influence the rate of aging progression. In this study, we identified cell cycle factors as potent regulators of health and longevity in

Search genes: cye-1 rrf-1

Entrez ID
Symbol
GenAge
Wormbase ID

172399
cye-1
View on GenAge (cye-1)
WBGene00000871

G1/S-specific cyclin-E

Locus: CELE_C37A2.4

Wormbase description: cye-1 encodes the sole C. elegans E-type cyclin; CYE-1 is required for progression through the mitotic cell cycle during embryonic, larval, and germline development; cye-1 is also required for endoreduplication in intestinal cells; CYE-1 is expressed ubiquitously in nuclei during embryonic development and postembryonically in proliferating blast cells, including germline stem cells; in the germline, CYE-1 levels are negatively regulated in meiotic cells by a CUL-1, SKR-1/2, PROM-1 SCF ubiquitin ligase.

Entrez ID
Symbol
GenAge
Wormbase ID

172523
rrf-1
View on GenAge (rrf-1)
WBGene00004508

RNA-dependent RNA polymerase Family

Locus: CELE_F26A3.8

Wormbase description: rrf-1 encodes an RNA-directed RNA polymerase (RdRP) homolog required for somatic (but not germline) RNAi; RRF-1 is also required for 'transitive interference'.

Orthologs of cye-1;rrf-1 in SynergyAge

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Species	Gene

Not in SynergyAge
Species	Gene

Orthologs of cye-1 in SynergyAge

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Species	Gene

Not in SynergyAge
Species	Gene
Drosophila melanogaster	CycE
Mus musculus	Ccne1
Mus musculus	Ccne2

Orthologs of rrf-1 in SynergyAge

Show in SynergyAge
Species	Gene