cye-1;daf-16

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Genetic mutants with cye-1, daf-16 alterations

Names of genes are ordered alphabetically. For the order of interventions, please see the specific paper.

Temperature °C
20
Diet
NGM
Lifespan (days)
19.2
Lifespan change (compared to wild type)
-1.03%
Phenotype
daf-16(mgDf47) null mutation significantly suppressed the longevity of cye-1(RNAi).
Lifespan comparisons
Double mutant cye-1(RNAi);daf-16(mgDf47) has a lifespan of 19.2 days, while single mutant cye-1(RNAi) has a lifespan of 25.3 days, single mutant daf-16(mgDf47) has a lifespan of 17.2 days and wild type has a lifespan of 19.4 days.
Type of interaction
See methods
Opposite lifespan effects of single mutants
Citation
View abstract
Dottermusch M et al., 2016, Cell cycle controls stress response and longevity in C. elegans. Aging (Albany NY). 8(9):2100-2126 27668945 Click here to select all mutants from this PubMed ID in the graph
Abstract
Recent studies have revealed a variety of genes and mechanisms that influence the rate of aging progression. In this study, we identified cell cycle factors as potent regulators of health and longevity in

Temperature °C
20
Diet
NGM
Lifespan (days)
19.5
Lifespan change (compared to wild type)
-2.99%
Phenotype
daf-16(mgDf47) null mutation significantly suppressed the longevity of cye-1(RNAi).
Lifespan comparisons
Double mutant cye-1(RNAi);daf-16(mgDf47) has a lifespan of 19.5 days, while single mutant cye-1(RNAi) has a lifespan of 26.7 days, single mutant daf-16(mgDf47) has a lifespan of 17.5 days and wild type has a lifespan of 20.1 days.
Type of interaction
See methods
Opposite lifespan effects of single mutants
Citation
View abstract
Dottermusch M et al., 2016, Cell cycle controls stress response and longevity in C. elegans. Aging (Albany NY). 8(9):2100-2126 27668945 Click here to select all mutants from this PubMed ID in the graph
Abstract
Recent studies have revealed a variety of genes and mechanisms that influence the rate of aging progression. In this study, we identified cell cycle factors as potent regulators of health and longevity in

Temperature °C
20
Diet
NGM
Lifespan (days)
18.9
Lifespan change (compared to wild type)
0.53%
Phenotype
daf-16(mgDf47) null mutation significantly suppressed the longevity of cye-1(RNAi).
Lifespan comparisons
Double mutant cye-1(RNAi);daf-16(mgDf47) has a lifespan of 18.9 days, while single mutant cye-1(RNAi) has a lifespan of 24.2 days, single mutant daf-16(mgDf47) has a lifespan of 17.0 days and wild type has a lifespan of 18.8 days.
Type of interaction
See methods
Opposite lifespan effects of single mutants
Citation
View abstract
Dottermusch M et al., 2016, Cell cycle controls stress response and longevity in C. elegans. Aging (Albany NY). 8(9):2100-2126 27668945 Click here to select all mutants from this PubMed ID in the graph
Abstract
Recent studies have revealed a variety of genes and mechanisms that influence the rate of aging progression. In this study, we identified cell cycle factors as potent regulators of health and longevity in

Names of genes are ordered alphabetically. For the order of interventions, please see the specific paper.

Temperature °C
20
Diet
NGM
Lifespan (days)
18.5
Lifespan change (compared to wild type)
-4.15%
Phenotype
The longevity of cye-1(RNAi) was suppressed by daf-16(mu86) mutation.
Lifespan comparisons
Double mutant cye-1(RNAi);daf-16(mu86) has a lifespan of 18.5 days, while single mutant cye-1(RNAi) has a lifespan of 23.8 days, single mutant daf-16(mu86) has a lifespan of 16.3 days and wild type has a lifespan of 19.3 days.
Type of interaction
See methods
Opposite lifespan effects of single mutants
Citation
View abstract
Dottermusch M et al., 2016, Cell cycle controls stress response and longevity in C. elegans. Aging (Albany NY). 8(9):2100-2126 27668945 Click here to select all mutants from this PubMed ID in the graph
Abstract
Recent studies have revealed a variety of genes and mechanisms that influence the rate of aging progression. In this study, we identified cell cycle factors as potent regulators of health and longevity in

Temperature °C
20
Diet
NGM
Lifespan (days)
19.5
Phenotype
The longevity of cye-1(RNAi) was suppressed by daf-16(mu86) mutation.
Lifespan comparisons
Double mutant cye-1(RNAi);daf-16(mu86) has a lifespan of 19.5 days, while single mutant cye-1(RNAi) has a lifespan of 23.7 days, single mutant daf-16(mu86) has a lifespan of 17.0 days and wild type has a lifespan of 19.5 days.
Type of interaction
See methods
Opposite lifespan effects of single mutants
Citation
View abstract
Dottermusch M et al., 2016, Cell cycle controls stress response and longevity in C. elegans. Aging (Albany NY). 8(9):2100-2126 27668945 Click here to select all mutants from this PubMed ID in the graph
Abstract
Recent studies have revealed a variety of genes and mechanisms that influence the rate of aging progression. In this study, we identified cell cycle factors as potent regulators of health and longevity in

Temperature °C
20
Diet
NGM
Lifespan (days)
19.1
Lifespan change (compared to wild type)
-1.55%
Phenotype
The longevity of cye-1(RNAi) was suppressed by daf-16(mu86) mutation.
Lifespan comparisons
Double mutant cye-1(RNAi);daf-16(mu86) has a lifespan of 19.1 days, while single mutant cye-1(RNAi) has a lifespan of 24.5 days, single mutant daf-16(mu86) has a lifespan of 16.7 days and wild type has a lifespan of 19.4 days.
Type of interaction
See methods
Opposite lifespan effects of single mutants
Citation
View abstract
Dottermusch M et al., 2016, Cell cycle controls stress response and longevity in C. elegans. Aging (Albany NY). 8(9):2100-2126 27668945 Click here to select all mutants from this PubMed ID in the graph
Abstract
Recent studies have revealed a variety of genes and mechanisms that influence the rate of aging progression. In this study, we identified cell cycle factors as potent regulators of health and longevity in

Temperature °C
20
Diet
NGM
Lifespan (days)
16.0
Lifespan change (compared to wild type)
-15.34%
Phenotype
The longevity of cye-1(RNAi) was suppressed by daf-16(mu86) mutation.
Lifespan comparisons
Double mutant cye-1(RNAi);daf-16(mu86) has a lifespan of 16.0 days, while single mutant cye-1(RNAi) has a lifespan of 23.5 days, single mutant daf-16(mu86) has a lifespan of 14.6 days and wild type has a lifespan of 18.9 days.
Type of interaction
See methods
Opposite lifespan effects of single mutants
Citation
View abstract
Dottermusch M et al., 2016, Cell cycle controls stress response and longevity in C. elegans. Aging (Albany NY). 8(9):2100-2126 27668945 Click here to select all mutants from this PubMed ID in the graph
Abstract
Recent studies have revealed a variety of genes and mechanisms that influence the rate of aging progression. In this study, we identified cell cycle factors as potent regulators of health and longevity in

Search genes: cye-1 daf-16

Entrez ID
Symbol
GenAge
Wormbase ID

172399
cye-1
View on GenAge (cye-1)
WBGene00000871

G1/S-specific cyclin-E

Locus: CELE_C37A2.4

Wormbase description: cye-1 encodes the sole C. elegans E-type cyclin; CYE-1 is required for progression through the mitotic cell cycle during embryonic, larval, and germline development; cye-1 is also required for endoreduplication in intestinal cells; CYE-1 is expressed ubiquitously in nuclei during embryonic development and postembryonically in proliferating blast cells, including germline stem cells; in the germline, CYE-1 levels are negatively regulated in meiotic cells by a CUL-1, SKR-1/2, PROM-1 SCF ubiquitin ligase.

Entrez ID
Symbol
GenAge
Wormbase ID

172981
daf-16
View on GenAge (daf-16)
WBGene00000912

Forkhead box protein O;hypothetical protein

Locus: CELE_R13H8.1

Wormbase description: daf-16 encodes the sole C. elegans forkhead box O (FOXO) homologue; DAF-16 functions as a transcription factor that acts in the insulin/IGF-1-mediated signaling (IIS) pathway that regulates dauer formation, longevity, fat metabolism, stress response, and innate immunity; DAF-16 regulates these various processes through isoform-specific expression, isoform-specific regulation by different AKT kinases, and differential regulation of target genes; DAF-16 can interact with the CBP-1 transcription cofactor in vitro, and interacts genetically with other genes in the insulin signaling and with daf-12, which encodes a nuclear hormone receptor; DAF-16 is activated in response to DNA damage during development and co-regulated by EGL-27, alleviates DNA-damage-induced developmental arrest by inducing DAF-16-associated element (DAE)-regulated genes; DAF-16 is broadly expressed but displays isoform-specific tissue enrichment; DAF-16 localizes to both the cytoplasm and the nucleus, with the ratio between the two an important regulator of function.

Orthologs of cye-1;daf-16 in SynergyAge

Show in SynergyAge
Species	Gene

Not in SynergyAge
Species	Gene
Mus musculus	Ccne1;Foxo6
Mus musculus	Ccne1;Foxo1
Mus musculus	Ccne1;Foxo4
Mus musculus	Ccne1;Foxo3
Mus musculus	Ccne2;Foxo6
Mus musculus	Ccne2;Foxo1
Mus musculus	Ccne2;Foxo4
Mus musculus	Ccne2;Foxo3

Orthologs of cye-1 in SynergyAge

Show in SynergyAge
Species	Gene

Not in SynergyAge
Species	Gene
Drosophila melanogaster	CycE
Mus musculus	Ccne1
Mus musculus	Ccne2

Orthologs of daf-16 in SynergyAge

Show in SynergyAge
Species	Gene

Not in SynergyAge
Species	Gene
Mus musculus	Foxo6
Mus musculus	Foxo1
Mus musculus	Foxo4
Mus musculus	Foxo3