B0511.8;eat-2

Lifespan changes: From wild type to B0511.8;eat-2

There is no network for this step.
Fullscreen mode
Hide graph
Legend

Genetic mutants with B0511.8, eat-2 alterations

    Names of genes are ordered alphabetically. For the order of interventions, please see the specific paper.
  • Temperature °C

    20

  • Diet

    NGM

  • Lifespan (days)

    28.7

  • Lifespan change (compared to wild type)

    41.38%

  • Phenotype

    RNAi inactivation of B0511.8 further extends longevity of control and eat-2(ad465) mutants.

  • Lifespan comparisons

    Double mutant B0511.8(RNAi);eat-2(ad465) has a lifespan of 28.7 days, while single mutant B0511.8(RNAi) has a lifespan of 24.5 days, single mutant eat-2(ad465) has a lifespan of 22.9 days and wild type has a lifespan of 20.3 days.

  • Type of interaction
    See methods

    Synergistic (positive)

  • Citation
    View abstract

    Chen D et al., 2007, Longevity determined by developmental arrest genes in Caenorhabditis elegans. Aging Cell. 6(4):525-33 PubMed 17521386 Click here to select all mutants from this PubMed ID in the graph

Search genes: B0511.8 eat-2
  • Symbol
  • GenAge

No gene information for B0511.8


  • Entrez ID
  • Symbol
  • GenAge
  • Wormbase ID

Neuronal acetylcholine receptor subunit eat-2


Locus: CELE_Y48B6A.4


Wormbase description: eat-2 encodes a ligand-gated ion channel subunit most closely related to the non-alpha-subunits of nicotinic acetylcholine receptors (nAChR); EAT-2 functions postsynaptically in pharyngeal muscle to regulate the rate of pharyngeal pumping; eat-2 is also required for normal life span and defecation; a functional EAT-2::GFP fusion protein localizes to two small dots near the junction of pharyngeal muscles pm4 and pm5, which is the site of the posterior-most MC motor neuron processes and the MC synapse; eat-2 genetically interacts with eat-18, which encodes a predicted novel transmembrane protein expressed in pharyngeal muscle and required for proper function of pharyngeal nicotonic receptors.


Orthologs of B0511.8;eat-2 in SynergyAge
Show in SynergyAge
Species Gene
Orthologs of B0511.8 in SynergyAge
Show in SynergyAge
Species Gene
Orthologs of eat-2 in SynergyAge
Show in SynergyAge
Species Gene
About

SynergyAge database hosts high-quality, manually curated information about the synergistic and antagonistic lifespan effects of genetic interventions in model organisms, also allowing users to explore the longevity relationships between genes in a visual way.

Read more about SynergyAge database

How to cite us

If you would like to cite this database please use:

Bunu, G., Toren, D., Ion, C. et al. SynergyAge, a curated database for synergistic and antagonistic interactions of longevity-associated genes. Sci Data 7, 366 (2020). https://doi.org/10.1038/s41597-020-00710-z

Contact
Robi Tacutu, Ph.D.
Head: Systems Biology of Aging Group, Bioinformatics & Structural Biochemistry Department
Institute of Biochemistry, Ground floor
Splaiul Independentei 296, Bucharest, Romania
Email:

Group webpage: www.aging-research.group