clk-2;gro-1

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Genetic mutants with clk-2, gro-1 alterations

Names of genes are ordered alphabetically. For the order of interventions, please see the specific paper.

Temperature °C
18
Lifespan (days)
12.3
Lifespan change (compared to wild type)
-17.45%
Phenotype
gro-1(e2400); clk-2(qm37) double mutants have a mean life-span similar to that of the wild type.
Lifespan comparisons
Double mutant clk-2(qm37);gro-1(e2400) has a lifespan of 12.3 days, while single mutant clk-2(qm37) has a lifespan of 18.7 days, single mutant gro-1(e2400) has a lifespan of 19.2 days and wild type has a lifespan of 14.9 days.
Type of interaction
See methods
Antagonistic (negative)
Citation
View abstract
Lakowski B, Hekimi S, 1996, Determination of life-span in Caenorhabditis elegans by four clock genes. Science. 272(5264):1010-3 8638122 Click here to select all mutants from this PubMed ID in the graph
Abstract
The nematode worm Caenorhabditis elegans is a model system for the study of the genetic basis of aging. Maternal-effect mutations in four genes--clk-1, clk-2, clk-3, and gro-1--interact genetically to determine both the duration of development and life-span. Analysis of the phenotypes of these mutants suggests the existence of a general physiological clock in the worm. Mutations in certain genes involved in dauer formation (an alternative larval stage induced by adverse conditions in which development is arrested) can also extend life-span, but the life extension of Clock mutants appears to be independent of these genes. The daf-2(e1370) clk-1(e2519) worms, which carry life-span-extending mutations from two different pathways, live nearly five times as long as wild-type worms.

Temperature °C
15
Lifespan (days)
21.4
Lifespan comparisons
Double mutant clk-2(qm37);gro-1(e2400) has a lifespan of 21.4 days, while single mutant clk-2(qm37) has a lifespan of 24.6 days and single mutant gro-1(e2400) has a lifespan of 26.0 days.
Type of interaction
See methods
Contains dependence
Citation
View abstract
Lakowski B, Hekimi S, 1996, Determination of life-span in Caenorhabditis elegans by four clock genes. Science. 272(5264):1010-3 8638122 Click here to select all mutants from this PubMed ID in the graph
Abstract
The nematode worm Caenorhabditis elegans is a model system for the study of the genetic basis of aging. Maternal-effect mutations in four genes--clk-1, clk-2, clk-3, and gro-1--interact genetically to determine both the duration of development and life-span. Analysis of the phenotypes of these mutants suggests the existence of a general physiological clock in the worm. Mutations in certain genes involved in dauer formation (an alternative larval stage induced by adverse conditions in which development is arrested) can also extend life-span, but the life extension of Clock mutants appears to be independent of these genes. The daf-2(e1370) clk-1(e2519) worms, which carry life-span-extending mutations from two different pathways, live nearly five times as long as wild-type worms.

Search genes: clk-2 gro-1

Entrez ID
Symbol
GenAge
Wormbase ID

176065
clk-2
View on GenAge (clk-2)
WBGene00000537

Telomere length regulation protein clk-2

Locus: CELE_C07H6.6

Wormbase description: The clk-2 gene encodes an ortholog of the S. cerevisiae telomere length-regulating protein Tel2p that has been shown to bind a number of DNA structures in vitro, including single-, double- and four-stranded DNA; in C. elegans, CLK-2 activity is required for the DNA damage and S phase replication checkpoints, for embryonic development, and for normal biological rhythms and life span; a functional CLK-2::GFP fusion protein is detected exclusively in the cytoplasm of somatic tissues.

Entrez ID
Symbol
GenAge
Wormbase ID

175725
gro-1
View on GenAge (gro-1)
WBGene00001740

hypothetical protein

Locus: CELE_ZC395.6

Wormbase description: gro-1 encodes two isoforms of the C. elegans isopentenylpyroptiosphate:tRNA transferase (IPT) ortholog; by homology, GRO-1 is predicted to function in modification of a subset of tRNAs; in C. elegans, a loss-of-function mutation in gro-1 results in delayed embryogenesis and postembryonic development, slower rates of adult behaviors, reduced brood size, and a genetic background-specific increase in adult life span; gro-1's effect on embryonic development exhibits a strict maternal effect; GRO-1::GFP fusion proteins are widely expressed and localize to the cytoplasm, nucleus, and mitochondria.

Orthologs of clk-2;gro-1 in SynergyAge

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Species	Gene

Not in SynergyAge
Species	Gene
Mus musculus	Telo2;Trit1
Mus musculus	Trit1;Telo2

Orthologs of clk-2 in SynergyAge

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Species	Gene

Not in SynergyAge
Species	Gene
Mus musculus	Telo2

Orthologs of gro-1 in SynergyAge

Show in SynergyAge
Species	Gene

Not in SynergyAge
Species	Gene
Drosophila melanogaster	CG31381
Mus musculus	Trit1