daf-16;gro-1

There is no network for this step.

Fullscreen mode

Hide graph

Legend

Genetic mutants with daf-16, gro-1 alterations

Names of genes are ordered alphabetically. For the order of interventions, please see the specific paper.

Temperature °C
18
Lifespan (days)
17.8
Lifespan change (compared to wild type)
19.46%
Phenotype
daf-16(m26) does not suppress the life-span extension seen in gro-1(e2400).
Lifespan comparisons
Double mutant daf-16(m26);gro-1(e2400) has a lifespan of 17.8 days, while single mutant gro-1(e2400) has a lifespan of 19.2 days, single mutant daf-16(m26) has a lifespan of 15.1 days and wild type has a lifespan of 14.9 days.
Type of interaction
See methods
Dependent
Citation
View abstract
Lakowski B, Hekimi S, 1996, Determination of life-span in Caenorhabditis elegans by four clock genes. Science. 272(5264):1010-3 8638122 Click here to select all mutants from this PubMed ID in the graph
Abstract
The nematode worm Caenorhabditis elegans is a model system for the study of the genetic basis of aging. Maternal-effect mutations in four genes--clk-1, clk-2, clk-3, and gro-1--interact genetically to determine both the duration of development and life-span. Analysis of the phenotypes of these mutants suggests the existence of a general physiological clock in the worm. Mutations in certain genes involved in dauer formation (an alternative larval stage induced by adverse conditions in which development is arrested) can also extend life-span, but the life extension of Clock mutants appears to be independent of these genes. The daf-2(e1370) clk-1(e2519) worms, which carry life-span-extending mutations from two different pathways, live nearly five times as long as wild-type worms.

Search genes: daf-16 gro-1

Entrez ID
Symbol
GenAge
Wormbase ID

172981
daf-16
View on GenAge (daf-16)
WBGene00000912

Forkhead box protein O;hypothetical protein

Locus: CELE_R13H8.1

Wormbase description: daf-16 encodes the sole C. elegans forkhead box O (FOXO) homologue; DAF-16 functions as a transcription factor that acts in the insulin/IGF-1-mediated signaling (IIS) pathway that regulates dauer formation, longevity, fat metabolism, stress response, and innate immunity; DAF-16 regulates these various processes through isoform-specific expression, isoform-specific regulation by different AKT kinases, and differential regulation of target genes; DAF-16 can interact with the CBP-1 transcription cofactor in vitro, and interacts genetically with other genes in the insulin signaling and with daf-12, which encodes a nuclear hormone receptor; DAF-16 is activated in response to DNA damage during development and co-regulated by EGL-27, alleviates DNA-damage-induced developmental arrest by inducing DAF-16-associated element (DAE)-regulated genes; DAF-16 is broadly expressed but displays isoform-specific tissue enrichment; DAF-16 localizes to both the cytoplasm and the nucleus, with the ratio between the two an important regulator of function.

Entrez ID
Symbol
GenAge
Wormbase ID

175725
gro-1
View on GenAge (gro-1)
WBGene00001740

hypothetical protein

Locus: CELE_ZC395.6

Wormbase description: gro-1 encodes two isoforms of the C. elegans isopentenylpyroptiosphate:tRNA transferase (IPT) ortholog; by homology, GRO-1 is predicted to function in modification of a subset of tRNAs; in C. elegans, a loss-of-function mutation in gro-1 results in delayed embryogenesis and postembryonic development, slower rates of adult behaviors, reduced brood size, and a genetic background-specific increase in adult life span; gro-1's effect on embryonic development exhibits a strict maternal effect; GRO-1::GFP fusion proteins are widely expressed and localize to the cytoplasm, nucleus, and mitochondria.

Orthologs of daf-16;gro-1 in SynergyAge

Show in SynergyAge
Species	Gene

Not in SynergyAge
Species	Gene
Mus musculus	Foxo6;Trit1
Mus musculus	Foxo1;Trit1
Mus musculus	Foxo4;Trit1
Mus musculus	Foxo3;Trit1
Mus musculus	Trit1;Foxo6
Mus musculus	Trit1;Foxo1
Mus musculus	Trit1;Foxo4
Mus musculus	Trit1;Foxo3

Orthologs of daf-16 in SynergyAge

Show in SynergyAge
Species	Gene

Not in SynergyAge
Species	Gene
Mus musculus	Foxo6
Mus musculus	Foxo1
Mus musculus	Foxo4
Mus musculus	Foxo3

Orthologs of gro-1 in SynergyAge

Show in SynergyAge
Species	Gene

Not in SynergyAge
Species	Gene
Drosophila melanogaster	CG31381
Mus musculus	Trit1

About

SynergyAge database hosts high-quality, manually curated information about the synergistic and antagonistic lifespan effects of genetic interventions in model organisms, also allowing users to explore the longevity relationships between genes in a visual way.