cyc-2.1;rsks-1

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Genetic mutants with cyc-2.1, rsks-1 alterations

Names of genes are ordered alphabetically. For the order of interventions, please see the specific paper.

Temperature °C
20
Diet
NGM
Lifespan (days)
31.2
Lifespan change (compared to wild type)
65.08%
Phenotype
Knockdown of cyc-2.1 robustly extends lifespan in the wild-type and rsks-1(ok1255) mutant backgrounds.
Lifespan comparisons
Double mutant cyc-2.1(RNAi);rsks-1(ok1255) has a lifespan of 31.2 days, while single mutant cyc-2.1(RNAi) has a lifespan of 32.2 days, single mutant rsks-1(ok1255) has a lifespan of 22.4 days and wild type has a lifespan of 18.9 days.
Type of interaction
See methods
Dependent
Citation
View abstract
Lan J et al., 2019, Translational Regulation of Non-autonomous Mitochondrial Stress Response Promotes Longevity. Cell Rep. 28(4):1050-1062 31340143 Click here to select all mutants from this PubMed ID in the graph
Abstract
Reduced mRNA translation delays aging, but the underlying mechanisms remain underexplored. Mutations in both DAF-2 (IGF-1 receptor) and RSKS-1 (ribosomal S6 kinase/S6K) cause synergistic lifespan extension in C. elegans. To understand the roles of translational regulation in this process, we performed polysomal profiling and identified translationally regulated ribosomal and cytochrome c (CYC-2.1) genes as key mediators of longevity. cyc-2.1 knockdown significantly extends lifespan by activating the intestinal mitochondrial unfolded protein response (UPR

Temperature °C
20
Diet
NGM
Lifespan (days)
28.8
Lifespan change (compared to wild type)
44.00%
Phenotype
Knockdown of cyc-2.1 robustly extends lifespan in the wild-type and rsks-1(ok1255) mutant backgrounds.
Lifespan comparisons
Double mutant cyc-2.1(RNAi);rsks-1(ok1255) has a lifespan of 28.8 days, while single mutant cyc-2.1(RNAi) has a lifespan of 31.6 days, single mutant rsks-1(ok1255) has a lifespan of 21.9 days and wild type has a lifespan of 20.0 days.
Type of interaction
See methods
Dependent
Citation
View abstract
Lan J et al., 2019, Translational Regulation of Non-autonomous Mitochondrial Stress Response Promotes Longevity. Cell Rep. 28(4):1050-1062 31340143 Click here to select all mutants from this PubMed ID in the graph
Abstract
Reduced mRNA translation delays aging, but the underlying mechanisms remain underexplored. Mutations in both DAF-2 (IGF-1 receptor) and RSKS-1 (ribosomal S6 kinase/S6K) cause synergistic lifespan extension in C. elegans. To understand the roles of translational regulation in this process, we performed polysomal profiling and identified translationally regulated ribosomal and cytochrome c (CYC-2.1) genes as key mediators of longevity. cyc-2.1 knockdown significantly extends lifespan by activating the intestinal mitochondrial unfolded protein response (UPR

Search genes: cyc-2.1 rsks-1

Entrez ID
Symbol
GenAge
Wormbase ID

177243
cyc-2.1
View on GenAge (cyc-2.1)
WBGene00017121

Cytochrome c 2.1

Locus: CELE_E04A4.7

Wormbase description: cyc-2.1 encodes, along with cyc-2.2, one of two C. elegans cytochrome c proteins; the product of cyc-2.1 is predicted to function in the electron transport chain by transferring electrons from respiratory chain Complex III to Complex IV; large-scale RNAi screens indicate the cyc-2.1 activity is required for embryonic and larval development as well as for normal brood sizes and growth rates.

Entrez ID
Symbol
GenAge
Wormbase ID

176554
rsks-1
View on GenAge (rsks-1)
WBGene00012929

Ribosomal protein S6 kinase beta

Locus: CELE_Y47D3A.16

Wormbase description: rsks-1 encodes a putative ribosomal protein S6 kinase (S6K) required additively with IFG-1 for normally high levels of protein synthesis, and for normally short lifespan; RSKS-1's effect on lifespan is independent of DAF-16, ISP-1, and SIR-2.1, and does not correlate with juglone resistance, but does correlate with abnormally high resistance to starvation and (perhaps) thermotolerance; RSKS-1 is required for normal juglone resistance, as well as normally rapid growth and normal brood sizes; RSKS-1 is expressed in E-lineage embryonic cells, and in pharyngeal and hypodermal cells of larvae and adults; RSKS-1 is orthologous to human RPS6KB1 (OMIM:608938) and RPS6KB2 (OMIM:608939).

Orthologs of cyc-2.1;rsks-1 in SynergyAge

Show in SynergyAge
Species	Gene

Not in SynergyAge
Species	Gene
Drosophila melanogaster	Cyt-c-d;S6k
Drosophila melanogaster	Cyt-c-p;S6k
Mus musculus	Cyct;Rps6kb1
Mus musculus	Cyct;Rps6kb2
Mus musculus	Cycs;Rps6kb1
Mus musculus	Cycs;Rps6kb2
Mus musculus	Rps6kb1;Cyct
Mus musculus	Rps6kb1;Cycs
Mus musculus	Rps6kb2;Cyct
Mus musculus	Rps6kb2;Cycs

Orthologs of cyc-2.1 in SynergyAge

Show in SynergyAge
Species	Gene

Not in SynergyAge
Species	Gene
Drosophila melanogaster	Cyt-c-d
Drosophila melanogaster	Cyt-c-p
Mus musculus	Cyct
Mus musculus	Cycs

Orthologs of rsks-1 in SynergyAge

Show in SynergyAge
Species	Gene

Not in SynergyAge
Species	Gene
Drosophila melanogaster	S6k
Mus musculus	Rps6kb1
Mus musculus	Rps6kb2