atfs-1;cyc-2.1

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Genetic mutants with atfs-1, cyc-2.1 alterations

Names of genes are ordered alphabetically. For the order of interventions, please see the specific paper.

Temperature °C
20
Diet
NGM
Lifespan (days)
19.8
Lifespan change (compared to wild type)
4.76%
Phenotype
The cyc-2.1 RNAi-induced longevity phenotype is suppressed by a deletion mutant of atfs-1(gk3094).
Lifespan comparisons
Double mutant atfs-1(gk3094);cyc-2.1(RNAi) has a lifespan of 19.8 days, while single mutant cyc-2.1(RNAi) has a lifespan of 32.2 days, single mutant atfs-1(gk3094) has a lifespan of 19.1 days and wild type has a lifespan of 18.9 days.
Type of interaction
See methods
Dependent
Citation
View abstract
Lan J et al., 2019, Translational Regulation of Non-autonomous Mitochondrial Stress Response Promotes Longevity. Cell Rep. 28(4):1050-1062 31340143 Click here to select all mutants from this PubMed ID in the graph
Abstract
Reduced mRNA translation delays aging, but the underlying mechanisms remain underexplored. Mutations in both DAF-2 (IGF-1 receptor) and RSKS-1 (ribosomal S6 kinase/S6K) cause synergistic lifespan extension in C. elegans. To understand the roles of translational regulation in this process, we performed polysomal profiling and identified translationally regulated ribosomal and cytochrome c (CYC-2.1) genes as key mediators of longevity. cyc-2.1 knockdown significantly extends lifespan by activating the intestinal mitochondrial unfolded protein response (UPR

Temperature °C
20
Diet
NGM
Lifespan (days)
20.3
Lifespan change (compared to wild type)
1.50%
Phenotype
The cyc-2.1 RNAi-induced longevity phenotype is suppressed by a deletion mutant of atfs-1(gk3094).
Lifespan comparisons
Double mutant atfs-1(gk3094);cyc-2.1(RNAi) has a lifespan of 20.3 days, while single mutant cyc-2.1(RNAi) has a lifespan of 31.6 days, single mutant atfs-1(gk3094) has a lifespan of 19.7 days and wild type has a lifespan of 20.0 days.
Type of interaction
See methods
Opposite lifespan effects of single mutants
Citation
View abstract
Lan J et al., 2019, Translational Regulation of Non-autonomous Mitochondrial Stress Response Promotes Longevity. Cell Rep. 28(4):1050-1062 31340143 Click here to select all mutants from this PubMed ID in the graph
Abstract
Reduced mRNA translation delays aging, but the underlying mechanisms remain underexplored. Mutations in both DAF-2 (IGF-1 receptor) and RSKS-1 (ribosomal S6 kinase/S6K) cause synergistic lifespan extension in C. elegans. To understand the roles of translational regulation in this process, we performed polysomal profiling and identified translationally regulated ribosomal and cytochrome c (CYC-2.1) genes as key mediators of longevity. cyc-2.1 knockdown significantly extends lifespan by activating the intestinal mitochondrial unfolded protein response (UPR

Search genes: atfs-1 cyc-2.1

Entrez ID
Symbol
GenAge
Wormbase ID

179922
atfs-1
View on GenAge (atfs-1)
WBGene00013878

Stress activated transcription factor atfs-1

Locus: CELE_ZC376.7

Wormbase description: atfs-1 encodes a bZip transcription factor; ATFS-1 is required for the mitochondrial unfolded protein response (UPRmt); in wild-type animals, ATFS-1 is imported into the mitochondria and degraded, but in response to perturbed mitchondrial protein folding and decreased mitochondrial import efficiency, some ATFS-1 accumulates in the cytosol and then, traffics to the nucleus.

Entrez ID
Symbol
GenAge
Wormbase ID

177243
cyc-2.1
View on GenAge (cyc-2.1)
WBGene00017121

Cytochrome c 2.1

Locus: CELE_E04A4.7

Wormbase description: cyc-2.1 encodes, along with cyc-2.2, one of two C. elegans cytochrome c proteins; the product of cyc-2.1 is predicted to function in the electron transport chain by transferring electrons from respiratory chain Complex III to Complex IV; large-scale RNAi screens indicate the cyc-2.1 activity is required for embryonic and larval development as well as for normal brood sizes and growth rates.

Orthologs of atfs-1;cyc-2.1 in SynergyAge

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Species	Gene

Not in SynergyAge
Species	Gene

Orthologs of atfs-1 in SynergyAge

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Species	Gene

Orthologs of cyc-2.1 in SynergyAge

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Species	Gene

Not in SynergyAge
Species	Gene
Drosophila melanogaster	Cyt-c-d
Drosophila melanogaster	Cyt-c-p
Mus musculus	Cyct
Mus musculus	Cycs