aak-2;cyc-2.1

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Genetic mutants with aak-2, cyc-2.1 alterations

Names of genes are ordered alphabetically. For the order of interventions, please see the specific paper.

Temperature °C
20
Diet
NGM
Lifespan (days)
15.9
Lifespan change (compared to wild type)
-15.87%
Phenotype
Consistently, cyc-2.1 RNAi fails to extend lifespan of the aak-2(ok524) deletion mutant.
Lifespan comparisons
Double mutant aak-2(ok524);cyc-2.1(RNAi) has a lifespan of 15.9 days, while single mutant cyc-2.1(RNAi) has a lifespan of 32.2 days, single mutant aak-2(ok524) has a lifespan of 15.9 days and wild type has a lifespan of 18.9 days.
Type of interaction
See methods
Opposite lifespan effects of single mutants
Citation
View abstract
Lan J et al., 2019, Translational Regulation of Non-autonomous Mitochondrial Stress Response Promotes Longevity. Cell Rep. 28(4):1050-1062 31340143 Click here to select all mutants from this PubMed ID in the graph
Abstract
Reduced mRNA translation delays aging, but the underlying mechanisms remain underexplored. Mutations in both DAF-2 (IGF-1 receptor) and RSKS-1 (ribosomal S6 kinase/S6K) cause synergistic lifespan extension in C. elegans. To understand the roles of translational regulation in this process, we performed polysomal profiling and identified translationally regulated ribosomal and cytochrome c (CYC-2.1) genes as key mediators of longevity. cyc-2.1 knockdown significantly extends lifespan by activating the intestinal mitochondrial unfolded protein response (UPR

Temperature °C
20
Diet
NGM
Lifespan (days)
16.0
Lifespan change (compared to wild type)
-20.00%
Phenotype
Consistently, cyc-2.1 RNAi fails to extend lifespan of the aak-2(ok524) deletion mutant.
Lifespan comparisons
Double mutant aak-2(ok524);cyc-2.1(RNAi) has a lifespan of 16.0 days, while single mutant cyc-2.1(RNAi) has a lifespan of 31.6 days, single mutant aak-2(ok524) has a lifespan of 16.0 days and wild type has a lifespan of 20.0 days.
Type of interaction
See methods
Opposite lifespan effects of single mutants
Citation
View abstract
Lan J et al., 2019, Translational Regulation of Non-autonomous Mitochondrial Stress Response Promotes Longevity. Cell Rep. 28(4):1050-1062 31340143 Click here to select all mutants from this PubMed ID in the graph
Abstract
Reduced mRNA translation delays aging, but the underlying mechanisms remain underexplored. Mutations in both DAF-2 (IGF-1 receptor) and RSKS-1 (ribosomal S6 kinase/S6K) cause synergistic lifespan extension in C. elegans. To understand the roles of translational regulation in this process, we performed polysomal profiling and identified translationally regulated ribosomal and cytochrome c (CYC-2.1) genes as key mediators of longevity. cyc-2.1 knockdown significantly extends lifespan by activating the intestinal mitochondrial unfolded protein response (UPR

Search genes: aak-2 cyc-2.1

Entrez ID
Symbol
GenAge
Wormbase ID

181727
aak-2
View on GenAge (aak-2)
WBGene00020142

5'-AMP-activated protein kinase catalytic subunit alpha-2

Locus: CELE_T01C8.1

Wormbase description: aak-2 encodes one of two C. elegans homologs of the catalytic alpha subunit of AMP-activated protein kinases (AMPKs); in C. elegans, aak-2 functions downstream of environmental stressors, energy level signals (AMP:ATP ratio), and daf-2-mediated insulin signaling to positively regulate adult lifespan; in regulating lifespan, aak-2 likely acts in parallel with daf-16/FOXO; aak-2 activity is also required for dauer formation in daf-2 mutant animals at high temperature in a manner independent of the AMP:ATP ratio; in the germline, aak-2 functions downstream of daf-2 and daf-7, and in parallel to par-4 and aak-1, to negatively regulate germline proliferation during dauer development; in vitro, AAK-2 exhibits AMP-enhanced kinase activity against a known AMPK substrate, the SAMS peptide.

Entrez ID
Symbol
GenAge
Wormbase ID

177243
cyc-2.1
View on GenAge (cyc-2.1)
WBGene00017121

Cytochrome c 2.1

Locus: CELE_E04A4.7

Wormbase description: cyc-2.1 encodes, along with cyc-2.2, one of two C. elegans cytochrome c proteins; the product of cyc-2.1 is predicted to function in the electron transport chain by transferring electrons from respiratory chain Complex III to Complex IV; large-scale RNAi screens indicate the cyc-2.1 activity is required for embryonic and larval development as well as for normal brood sizes and growth rates.

Orthologs of aak-2;cyc-2.1 in SynergyAge

Show in SynergyAge
Species	Gene

Not in SynergyAge
Species	Gene
Drosophila melanogaster	AMPKalpha;Cyt-c-d
Drosophila melanogaster	AMPKalpha;Cyt-c-p
Mus musculus	Cyct;Prkaa1
Mus musculus	Cycs;Prkaa1
Mus musculus	Cyct;Prkaa2
Mus musculus	Cycs;Prkaa2
Mus musculus	Cyt-c-d;AMPKalpha
Mus musculus	Cyt-c-p;AMPKalpha

Orthologs of aak-2 in SynergyAge

Show in SynergyAge
Species	Gene

Not in SynergyAge
Species	Gene
Drosophila melanogaster	AMPKalpha
Mus musculus	Prkaa1
Mus musculus	Prkaa2

Orthologs of cyc-2.1 in SynergyAge

Show in SynergyAge
Species	Gene

Not in SynergyAge
Species	Gene
Drosophila melanogaster	Cyt-c-d
Drosophila melanogaster	Cyt-c-p
Mus musculus	Cyct
Mus musculus	Cycs