cyc-2.1;drp-1

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Genetic mutants with cyc-2.1, drp-1 alterations

Names of genes are ordered alphabetically. For the order of interventions, please see the specific paper.

Temperature °C
20
Diet
NGM
Lifespan (days)
28.6
Lifespan change (compared to wild type)
46.67%
Phenotype
cyc-2.1 RNAi treatment extends lifespan in wild-type animals by 66%, whereas the mean lifespan extension is significantly decreased to 42% in the drp-1(tm1108) mutant.
Lifespan comparisons
Double mutant cyc-2.1(RNAi);drp-1(tm1108) has a lifespan of 28.6 days, while single mutant cyc-2.1(RNAi) has a lifespan of 33.5 days, single mutant drp-1(tm1108) has a lifespan of 21.3 days and wild type has a lifespan of 19.5 days.
Type of interaction
See methods
Dependent
Citation
View abstract
Lan J et al., 2019, Translational Regulation of Non-autonomous Mitochondrial Stress Response Promotes Longevity. Cell Rep. 28(4):1050-1062 31340143 Click here to select all mutants from this PubMed ID in the graph
Abstract
Reduced mRNA translation delays aging, but the underlying mechanisms remain underexplored. Mutations in both DAF-2 (IGF-1 receptor) and RSKS-1 (ribosomal S6 kinase/S6K) cause synergistic lifespan extension in C. elegans. To understand the roles of translational regulation in this process, we performed polysomal profiling and identified translationally regulated ribosomal and cytochrome c (CYC-2.1) genes as key mediators of longevity. cyc-2.1 knockdown significantly extends lifespan by activating the intestinal mitochondrial unfolded protein response (UPR

Temperature °C
20
Diet
NGM
Lifespan (days)
29.7
Lifespan change (compared to wild type)
58.82%
Phenotype
cyc-2.1 RNAi treatment extends lifespan in wild-type animals by 66%, whereas the mean lifespan extension is significantly decreased to 42% in the drp-1(tm1108) mutant.
Lifespan comparisons
Double mutant cyc-2.1(RNAi);drp-1(tm1108) has a lifespan of 29.7 days, while single mutant cyc-2.1(RNAi) has a lifespan of 29.3 days, single mutant drp-1(tm1108) has a lifespan of 21.4 days and wild type has a lifespan of 18.7 days.
Type of interaction
See methods
Almost additive (positive)
Citation
View abstract
Lan J et al., 2019, Translational Regulation of Non-autonomous Mitochondrial Stress Response Promotes Longevity. Cell Rep. 28(4):1050-1062 31340143 Click here to select all mutants from this PubMed ID in the graph
Abstract
Reduced mRNA translation delays aging, but the underlying mechanisms remain underexplored. Mutations in both DAF-2 (IGF-1 receptor) and RSKS-1 (ribosomal S6 kinase/S6K) cause synergistic lifespan extension in C. elegans. To understand the roles of translational regulation in this process, we performed polysomal profiling and identified translationally regulated ribosomal and cytochrome c (CYC-2.1) genes as key mediators of longevity. cyc-2.1 knockdown significantly extends lifespan by activating the intestinal mitochondrial unfolded protein response (UPR

Temperature °C
20
Diet
NGM
Lifespan (days)
27.8
Lifespan change (compared to wild type)
45.55%
Phenotype
cyc-2.1 RNAi treatment extends lifespan in wild-type animals by 66%, whereas the mean lifespan extension is significantly decreased to 42% in the drp-1(tm1108) mutant.
Lifespan comparisons
Double mutant cyc-2.1(RNAi);drp-1(tm1108) has a lifespan of 27.8 days, while single mutant cyc-2.1(RNAi) has a lifespan of 32.4 days, single mutant drp-1(tm1108) has a lifespan of 18.1 days and wild type has a lifespan of 19.1 days.
Type of interaction
See methods
Opposite lifespan effects of single mutants
Citation
View abstract
Lan J et al., 2019, Translational Regulation of Non-autonomous Mitochondrial Stress Response Promotes Longevity. Cell Rep. 28(4):1050-1062 31340143 Click here to select all mutants from this PubMed ID in the graph
Abstract
Reduced mRNA translation delays aging, but the underlying mechanisms remain underexplored. Mutations in both DAF-2 (IGF-1 receptor) and RSKS-1 (ribosomal S6 kinase/S6K) cause synergistic lifespan extension in C. elegans. To understand the roles of translational regulation in this process, we performed polysomal profiling and identified translationally regulated ribosomal and cytochrome c (CYC-2.1) genes as key mediators of longevity. cyc-2.1 knockdown significantly extends lifespan by activating the intestinal mitochondrial unfolded protein response (UPR

Search genes: cyc-2.1 drp-1

Entrez ID
Symbol
GenAge
Wormbase ID

177243
cyc-2.1
View on GenAge (cyc-2.1)
WBGene00017121

Cytochrome c 2.1

Locus: CELE_E04A4.7

Wormbase description: cyc-2.1 encodes, along with cyc-2.2, one of two C. elegans cytochrome c proteins; the product of cyc-2.1 is predicted to function in the electron transport chain by transferring electrons from respiratory chain Complex III to Complex IV; large-scale RNAi screens indicate the cyc-2.1 activity is required for embryonic and larval development as well as for normal brood sizes and growth rates.

Entrez ID
Symbol
GenAge
Wormbase ID

177336
drp-1
View on GenAge (drp-1)
WBGene00001093

Dynamin-Related Protein

Locus: CELE_T12E12.4

Wormbase description: drp-1 encodes a dynamin-related protein, orthologous to Dnm1p in S. cerevisiae and DRP1 in mammals, that is required for severing of the mitochondrial outer membrane during mitochondrial division.

Orthologs of cyc-2.1;drp-1 in SynergyAge

Show in SynergyAge
Species	Gene

Not in SynergyAge
Species	Gene
Drosophila melanogaster	Cyt-c-d;Drp1
Drosophila melanogaster	Cyt-c-p;Drp1
Mus musculus	Cyct;Dnm1l
Mus musculus	Cycs;Dnm1l
Mus musculus	Dnm1l;Cyct
Mus musculus	Dnm1l;Cycs

Orthologs of cyc-2.1 in SynergyAge

Show in SynergyAge
Species	Gene

Not in SynergyAge
Species	Gene
Drosophila melanogaster	Cyt-c-d
Drosophila melanogaster	Cyt-c-p
Mus musculus	Cyct
Mus musculus	Cycs

Orthologs of drp-1 in SynergyAge

Show in SynergyAge
Species	Gene

Not in SynergyAge
Species	Gene
Drosophila melanogaster	Drp1
Mus musculus	Dnm1l