ced-4;cyc-2.1

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Genetic mutants with ced-4, cyc-2.1 alterations

Names of genes are ordered alphabetically. For the order of interventions, please see the specific paper.

Temperature °C
20
Diet
NGM
Lifespan (days)
31.11
Lifespan comparisons
Double mutant ced-4(n1162);cyc-2.1(RNAi) has a lifespan of 31.11 days, while single mutant ced-4(n1162) has a lifespan of 18.88 days.
Citation
View abstract
Lan J et al., 2019, Translational Regulation of Non-autonomous Mitochondrial Stress Response Promotes Longevity. Cell Rep. 28(4):1050-1062 31340143 Click here to select all mutants from this PubMed ID in the graph
Abstract
Reduced mRNA translation delays aging, but the underlying mechanisms remain underexplored. Mutations in both DAF-2 (IGF-1 receptor) and RSKS-1 (ribosomal S6 kinase/S6K) cause synergistic lifespan extension in C. elegans. To understand the roles of translational regulation in this process, we performed polysomal profiling and identified translationally regulated ribosomal and cytochrome c (CYC-2.1) genes as key mediators of longevity. cyc-2.1 knockdown significantly extends lifespan by activating the intestinal mitochondrial unfolded protein response (UPR

Search genes: ced-4 cyc-2.1

Entrez ID
Symbol
GenAge
Wormbase ID

175643
ced-4
View on GenAge (ced-4)
WBGene00000418

Cell death protein 4

Locus: CELE_C35D10.9

Wormbase description: ced-4 encodes a novel protein; along with CED-3, CED-4 is required for the initiation of programmed cell death; accordingly, genetic analyses indicate that ced-3 and ced-4 function upstream of ced-1, ced-2, and nuc-1 in the programmed cell death pathway; in yeast two-hybrid experiments, and upon coexpression in mammalian cells, CED-4 interacts with CED-9, an anti-apoptotic BCL-2 homolog; coexpression of CED-4 and CED-9 results in redistribution of CED-4 from the cytosol to organellar membranes, suggesting that CED-9 may negatively regulate CED-4 activity by sequestering CED-4 to intracellular membranes.

Entrez ID
Symbol
GenAge
Wormbase ID

177243
cyc-2.1
View on GenAge (cyc-2.1)
WBGene00017121

Cytochrome c 2.1

Locus: CELE_E04A4.7

Wormbase description: cyc-2.1 encodes, along with cyc-2.2, one of two C. elegans cytochrome c proteins; the product of cyc-2.1 is predicted to function in the electron transport chain by transferring electrons from respiratory chain Complex III to Complex IV; large-scale RNAi screens indicate the cyc-2.1 activity is required for embryonic and larval development as well as for normal brood sizes and growth rates.

Orthologs of ced-4;cyc-2.1 in SynergyAge

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Species	Gene

Not in SynergyAge
Species	Gene

Orthologs of ced-4 in SynergyAge

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Species	Gene

Orthologs of cyc-2.1 in SynergyAge

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Species	Gene

Not in SynergyAge
Species	Gene
Drosophila melanogaster	Cyt-c-d
Drosophila melanogaster	Cyt-c-p
Mus musculus	Cyct
Mus musculus	Cycs

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SynergyAge database hosts high-quality, manually curated information about the synergistic and antagonistic lifespan effects of genetic interventions in model organisms, also allowing users to explore the longevity relationships between genes in a visual way.