atfs-1;cco-1

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Genetic mutants with atfs-1, cco-1 alterations

Names of genes are ordered alphabetically. For the order of interventions, please see the specific paper.

Temperature °C
20
Diet
NGM
Lifespan (days)
30.0
Lifespan change (compared to wild type)
57.15%
Phenotype
Prolonged longevity by cyc-2.1 RNAi can be suppressed by an atfs-1(gk3094) deletion mutant.
Lifespan comparisons
Double mutant atfs-1(gk3094);cco-1(RNAi) has a lifespan of 30.0 days, while single mutant cco-1(RNAi) has a lifespan of 37.27 days, single mutant atfs-1(gk3094) has a lifespan of 19.09 days and wild type has a lifespan of 19.09 days.
Type of interaction
See methods
Dependent
Citation
View abstract
Lan J et al., 2019, Translational Regulation of Non-autonomous Mitochondrial Stress Response Promotes Longevity. Cell Rep. 28(4):1050-1062 31340143 Click here to select all mutants from this PubMed ID in the graph
Abstract
Reduced mRNA translation delays aging, but the underlying mechanisms remain underexplored. Mutations in both DAF-2 (IGF-1 receptor) and RSKS-1 (ribosomal S6 kinase/S6K) cause synergistic lifespan extension in C. elegans. To understand the roles of translational regulation in this process, we performed polysomal profiling and identified translationally regulated ribosomal and cytochrome c (CYC-2.1) genes as key mediators of longevity. cyc-2.1 knockdown significantly extends lifespan by activating the intestinal mitochondrial unfolded protein response (UPR

Search genes: atfs-1 cco-1

Entrez ID
Symbol
GenAge
Wormbase ID

179922
atfs-1
View on GenAge (atfs-1)
WBGene00013878

Stress activated transcription factor atfs-1

Locus: CELE_ZC376.7

Wormbase description: atfs-1 encodes a bZip transcription factor; ATFS-1 is required for the mitochondrial unfolded protein response (UPRmt); in wild-type animals, ATFS-1 is imported into the mitochondria and degraded, but in response to perturbed mitchondrial protein folding and decreased mitochondrial import efficiency, some ATFS-1 accumulates in the cytosol and then, traffics to the nucleus.

Symbol
GenAge

cco-1
View on GenAge (cco-1)

No gene information for cco-1

Orthologs of atfs-1;cco-1 in SynergyAge

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Orthologs of atfs-1 in SynergyAge

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Orthologs of cco-1 in SynergyAge

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SynergyAge database hosts high-quality, manually curated information about the synergistic and antagonistic lifespan effects of genetic interventions in model organisms, also allowing users to explore the longevity relationships between genes in a visual way.