daf-16;T06D8.6

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Genetic mutants with daf-16, T06D8.6 alterations

Names of genes are ordered alphabetically. For the order of interventions, please see the specific paper.

Temperature °C
20
Diet
NGM
Lifespan (days)
16.5
Lifespan change (compared to wild type)
-14.06%
Phenotype
RNAi inactivation of a T06D8.6 gene, key to mitochondrial function, markedly extended C. elegans lifespan on both daf-16 (mgDf47) and wild type.
Lifespan comparisons
Double mutant daf-16(mgDf47);T06D8.6(RNAi) has a lifespan of 16.5 days, while single mutant T06D8.6(RNAi) has a lifespan of 29.8 days, single mutant daf-16(mgDf47) has a lifespan of 12.5 days and wild type has a lifespan of 19.2 days.
Type of interaction
See methods
Opposite lifespan effects of single mutants
Citation
View abstract
Lee SS et al., 2003, A systematic RNAi screen identifies a critical role for mitochondria in C. elegans longevity. Nat Genet. 33(1):40-8 12447374 Click here to select all mutants from this PubMed ID in the graph
Abstract
We report a systematic RNA interference (RNAi) screen of 5,690 Caenorhabditis elegans genes for gene inactivations that increase lifespan. We found that genes important for mitochondrial function stand out as a principal group of genes affecting C. elegans lifespan. A classical genetic screen identified a mutation in the mitochondrial leucyl-tRNA synthetase gene (lrs-2) that impaired mitochondrial function and was associated with longer-lifespan. The long-lived worms with impaired mitochondria had lower ATP content and oxygen consumption, but differential responses to free-radical and other stresses. These data suggest that the longer lifespan of C. elegans with compromised mitochrondria cannot simply be assigned to lower free radical production and suggest a more complex coupling of metabolism and longevity.

Search genes: daf-16 T06D8.6

Entrez ID
Symbol
GenAge
Wormbase ID

172981
daf-16
View on GenAge (daf-16)
WBGene00000912

Forkhead box protein O;hypothetical protein

Locus: CELE_R13H8.1

Wormbase description: daf-16 encodes the sole C. elegans forkhead box O (FOXO) homologue; DAF-16 functions as a transcription factor that acts in the insulin/IGF-1-mediated signaling (IIS) pathway that regulates dauer formation, longevity, fat metabolism, stress response, and innate immunity; DAF-16 regulates these various processes through isoform-specific expression, isoform-specific regulation by different AKT kinases, and differential regulation of target genes; DAF-16 can interact with the CBP-1 transcription cofactor in vitro, and interacts genetically with other genes in the insulin signaling and with daf-12, which encodes a nuclear hormone receptor; DAF-16 is activated in response to DNA damage during development and co-regulated by EGL-27, alleviates DNA-damage-induced developmental arrest by inducing DAF-16-associated element (DAE)-regulated genes; DAF-16 is broadly expressed but displays isoform-specific tissue enrichment; DAF-16 localizes to both the cytoplasm and the nucleus, with the ratio between the two an important regulator of function.

Symbol
GenAge

T06D8.6
View on GenAge (T06D8.6)

No gene information for T06D8.6

Orthologs of daf-16;T06D8.6 in SynergyAge

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Species	Gene

Not in SynergyAge
Species	Gene

Orthologs of daf-16 in SynergyAge

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Species	Gene

Not in SynergyAge
Species	Gene
Mus musculus	Foxo6
Mus musculus	Foxo1
Mus musculus	Foxo4
Mus musculus	Foxo3

Orthologs of T06D8.6 in SynergyAge

Show in SynergyAge
Species	Gene

About

SynergyAge database hosts high-quality, manually curated information about the synergistic and antagonistic lifespan effects of genetic interventions in model organisms, also allowing users to explore the longevity relationships between genes in a visual way.