Lifespan changes: From wild type to Naam;Sirt1 DF = decrease in function; IF = increase in function
D-NAAM[42];Sir2[4.5],[5.26]
All of the fly stocks were maintained on standard cornmeal molasses medium. For the longevity experiments, the flies were mated and raised on sucrose medium.
36.88
-22.44%
In adult females, the extension of life span mediated by D-NAAM overexpression is completely abolished if the Sir2 gene is mutated.
Double mutant Naam(if);Sirt1(df) has a lifespan of 36.88 days, while single mutant Sirt1(df) has a lifespan of 44.88 days, single mutant Naam(if) has a lifespan of 36.88 days and wild type has a lifespan of 47.55 days.
Dependent
Balan V et al., 2008, Life span extension and neuronal cell protection by Drosophila nicotinamidase. J Biol Chem. 283(41):27810-9 18678867 Click here to select all mutants from this PubMed ID in the graph
D-NAAM[42];Sir2[4.5],[5.26]
All of the fly stocks were maintained on standard cornmeal molasses medium. For the longevity experiments, the flies were mated and raised on sucrose medium.
45.71
In adult males, the extension of life span mediated by D-NAAM overexpression is completely abolished if the Sir2 gene is mutated.
Double mutant Naam(if);Sirt1(df) has a lifespan of 45.71 days, while single mutant Sirt1(df) has a lifespan of 47.61 days, single mutant Naam(if) has a lifespan of 57.14 days and wild type has a lifespan of 45.71 days.
Antagonistic (positive)
Balan V et al., 2008, Life span extension and neuronal cell protection by Drosophila nicotinamidase. J Biol Chem. 283(41):27810-9 18678867 Click here to select all mutants from this PubMed ID in the graph
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SynergyAge database hosts high-quality, manually curated information about the synergistic and antagonistic lifespan effects of genetic interventions in model organisms, also allowing users to explore the longevity relationships between genes in a visual way.
If you would like to cite this database please use:
Bunu, G., Toren, D., Ion, C. et al. SynergyAge, a curated database for synergistic and antagonistic interactions of longevity-associated genes. Sci Data 7, 366 (2020). https://doi.org/10.1038/s41597-020-00710-z
Group webpage: www.aging-research.group