Lifespan changes: From wild type to Mhc;Vinc DF = decrease in function; IF = increase in function

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Genetic mutants with Mhc, Vinc alterations

    Names of genes are ordered alphabetically. For the order of interventions, please see the specific paper.
  • Strain


  • Temperature °C


  • Diet

    Standard agar-containing food.

  • Lifespan (days)


  • Lifespan change (compared to wild type)


  • Phenotype

    Cardiac-specific vinculin overexpression substantially prolonged median organismal life span by as much as 150%. These data suggest that VincHE hearts produce greater contractile forces, that vinculin overexpression can rescue diminished force production, and that cardiac-specific vinculin overexpression can increase longevity.

  • Lifespan comparisons

    Double mutant Mhc(if);Vinc(if) has a lifespan of 35.0 days, while single mutant Vinc(if) has a lifespan of 75.6 days, single mutant Mhc(if) has a lifespan of 23.1 days and wild type has a lifespan of 29.4 days.

  • Type of interaction
    See methods

    Opposite lifespan effects of single mutants

  • Citation
    View abstract

    Kaushik G et al., 2015, Vinculin network-mediated cytoskeletal remodeling regulates contractile function in the aging heart. Sci Transl Med. 7(292):292ra99 PubMed 26084806 Click here to select all mutants from this PubMed ID in the graph

Search genes: Mhc Vinc
  • Entrez ID
  • Symbol
  • GenAge
  • FlyBase ID

Myosin heavy chain

Locus: Dmel_CG17927

  • Entrez ID
  • Symbol
  • GenAge
  • FlyBase ID


Locus: Dmel_CG3299

Orthologs of Mhc;Vinc in SynergyAge
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Species Gene
Orthologs of Mhc in SynergyAge
Show in SynergyAge
Species Gene
Orthologs of Vinc in SynergyAge
Show in SynergyAge
Species Gene

SynergyAge database hosts high-quality, manually curated information about the synergistic and antagonistic lifespan effects of genetic interventions in model organisms, also allowing users to explore the longevity relationships between genes in a visual way.

Read more about SynergyAge database

How to cite us

If you would like to cite this database please use:

Bunu, G., Toren, D., Ion, C. et al. SynergyAge, a curated database for synergistic and antagonistic interactions of longevity-associated genes. Sci Data 7, 366 (2020).

Robi Tacutu, Ph.D.
Head: Systems Biology of Aging Group, Bioinformatics & Structural Biochemistry Department
Institute of Biochemistry, Ground floor
Splaiul Independentei 296, Bucharest, Romania

Group webpage: