Lifespan changes: From wild type to p38a;p38b DF = decrease in function; IF = increase in function

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Genetic mutants with p38a, p38b alterations

    Names of genes are ordered alphabetically. For the order of interventions, please see the specific paper.
  • Strain


  • Temperature °C


  • Diet

    Standard Drosophila culture medium

  • Lifespan (days)


  • Lifespan change (compared to wild type)


  • Phenotype

    A double mutant combination of the hypomorphic p38Kb?25 allele and p38Kadel (p38K-DKO) had a severely reduced lifespan. Single mutants of p38Ka (p38Kadel) or p38Kb (p38K?45) also had significantly reduced lifespan.

  • Lifespan comparisons

    Double mutant p38a(df);p38b(df) has a lifespan of 3.0 days, while single mutant p38b(df) has a lifespan of 19.0 days, single mutant p38a(df) has a lifespan of 34.0 days and wild type has a lifespan of 49.0 days.

  • Type of interaction
    See methods

    Synergistic (negative)

  • Citation
    View abstract

    Vrailas-Mortimer A et al., 2011, A muscle-specific p38 MAPK/Mef2/MnSOD pathway regulates stress, motor function, and life span in Drosophila. Dev Cell. 21(4):783-95 PubMed 22014527 Click here to select all mutants from this PubMed ID in the graph

Search genes: p38a p38b
  • Entrez ID
  • Symbol
  • GenAge
  • FlyBase ID

p38a MAP kinase

Locus: Dmel_CG5475

  • Entrez ID
  • Symbol
  • GenAge
  • FlyBase ID

p38b MAP kinase

Locus: Dmel_CG7393

Orthologs of p38a;p38b in SynergyAge
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Species Gene
Orthologs of p38a in SynergyAge
Show in SynergyAge
Species Gene
Caenorhabditis elegans pmk-1
Orthologs of p38b in SynergyAge
Show in SynergyAge
Species Gene
Caenorhabditis elegans pmk-1

SynergyAge database hosts high-quality, manually curated information about the synergistic and antagonistic lifespan effects of genetic interventions in model organisms, also allowing users to explore the longevity relationships between genes in a visual way.

Read more about SynergyAge database

How to cite us

If you would like to cite this database please use:

Bunu, G., Toren, D., Ion, C. et al. SynergyAge, a curated database for synergistic and antagonistic interactions of longevity-associated genes. Sci Data 7, 366 (2020). https://doi.org/10.1038/s41597-020-00710-z

Robi Tacutu, Ph.D.
Head: Systems Biology of Aging Group, Bioinformatics & Structural Biochemistry Department
Institute of Biochemistry, Ground floor
Splaiul Independentei 296, Bucharest, Romania

Group webpage: www.aging-research.group