Lifespan changes: From wild type to foxo;Lrrk DF = decrease in function; IF = increase in function

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Genetic mutants with foxo, Lrrk alterations

    Names of genes are ordered alphabetically. For the order of interventions, please see the specific paper.
  • Strain


  • Temperature °C


  • Diet

    Fly food vials containing 250 ml of yeast paste and 25 mg/ml of RU486.

  • Lifespan (days)


  • Lifespan change (compared to wild type)


  • Lifespan comparisons

    Double mutant foxo(if);Lrrk(df) has a lifespan of 27.38 days, while single mutant foxo(if) has a lifespan of 27.69 days and wild type has a lifespan of 29.84 days.

  • Type of interaction
    See methods

    Partially known monotony. Negative epistasis

  • Citation
    View abstract

    Kanao T et al., 2010, Activation of FoxO by LRRK2 induces expression of proapoptotic proteins and alters survival of postmitotic dopaminergic neuron in Drosophila. Hum Mol Genet. 19(19):3747-58 PubMed 20624856 Click here to select all mutants from this PubMed ID in the graph

Search genes: foxo Lrrk
  • Entrez ID
  • Symbol
  • GenAge
  • FlyBase ID

forkhead box, sub-group O

Locus: Dmel_CG3143

  • Entrez ID
  • Symbol
  • GenAge
  • FlyBase ID

Leucine-rich repeat kinase

Locus: Dmel_CG5483

Orthologs of foxo;Lrrk in SynergyAge
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Species Gene
Orthologs of foxo in SynergyAge
Show in SynergyAge
Species Gene
Orthologs of Lrrk in SynergyAge
Show in SynergyAge
Species Gene

SynergyAge database hosts high-quality, manually curated information about the synergistic and antagonistic lifespan effects of genetic interventions in model organisms, also allowing users to explore the longevity relationships between genes in a visual way.

Read more about SynergyAge database

How to cite us

If you would like to cite this database please use:

Bunu, G., Toren, D., Ion, C. et al. SynergyAge, a curated database for synergistic and antagonistic interactions of longevity-associated genes. Sci Data 7, 366 (2020).

Robi Tacutu, Ph.D.
Head: Systems Biology of Aging Group, Bioinformatics & Structural Biochemistry Department
Institute of Biochemistry, Ground floor
Splaiul Independentei 296, Bucharest, Romania

Group webpage: