ftt-2;pdk-1

14-3-3-like protein 2;Fourteen-Three-Three family

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Locus: CELE_F52D10.3

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Wormbase description: ftt-2 encodes a 14-3-3 protein; FTT-2 is required for regulating the localization of the product of YAP-1, a Yes-associated protein (Yap) homolog, between the cytoplasm and the nucleus.

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3-phosphoinositide-dependent protein kinase 1

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Locus: CELE_H42K12.1

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Wormbase description: pdk-1 encodes the C. elegans 3-phosphoinositide-dependent kinase 1 ortholog; PDK-1 is a component of the DAF-2/insulin receptor-like signaling pathway and accordingly, functions to regulate such processes as dauer larvae formation, longevity, and salt chemotaxis learning; genetic analyses indicate that, in regulating dauer arrest, PDK-1 acts downstream of AGE-1/PI3K and upstream of the AKT-1 and AKT-2 kinases; a PDK-1::GFP fusion protein is expressed broadly beginning in late stage embryos and continuing on through adulthood; expression is seen in head, tail, and ventral cord motor neurons, pharyngeal tissues, hypodermal cells, the intestine, and the somatic gonad; in neurons, the PDK-1::GFP localizes to cell bodies and processes, with occasional expression seen in some neuronal nuclei.

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