ftt-1;pdk-1

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Genetic mutants with ftt-1, pdk-1 alterations

Names of genes are ordered alphabetically. For the order of interventions, please see the specific paper.

Temperature °C
20
Diet
OP50
Lifespan (days)
19.5
Lifespan change (compared to wild type)
3.17%
Phenotype
The ftt-1 RNAi didn't induce a significant life span modulation in comparison with control. This result is relevant to a negative modulation of pdk-1 activity by ftt-2 that can be highlighted here by a life span shortening effect upon RNAi.
Lifespan comparisons
Double mutant ftt-1(RNAi);pdk-1(mg142) has a lifespan of 19.5 days, while single mutant ftt-1(RNAi) has a lifespan of 16.4 days, single mutant pdk-1(mg142) has a lifespan of 19.1 days and wild type has a lifespan of 18.9 days.
Type of interaction
See methods
Opposite lifespan effects of single mutants
Citation
View abstract
Araiz C et al., 2008, 14-3-3 regulates life span by both DAF-16-dependent and -independent mechanisms in Caenorhabditis elegans. Exp Gerontol. 43(6):505-19 18423931 Click here to select all mutants from this PubMed ID in the graph
Abstract
Caenorhabditis elegans life span, stress resistance and metabolism are regulated by the Insulin/IGF-1/DAF-2/DAF-16 pathway. DAF-16, a member of FOXO/Forkhead transcription factor family, can be targeted by 14-3-3 proteins to promote stress resistance. We have identified a 14-3-3 C. elegans homolog which promotes life span by both DAF-2-dependent and -independent mechanisms and by an unexpected DAF-16-independent mechanism. Our results demonstrate that C. elegans 14-3-3 proteins modulate stress-responsive genes throughout adulthood. In conclusion, 14-3-3 can be considered as an acute stress-responsive regulator as well as a sustained modulator of the Insulin/IGF-1/DAF-2/DAF-16 regulatory pathway in promoting life expectancy of growing old worms.

Names of genes are ordered alphabetically. For the order of interventions, please see the specific paper.

Temperature °C
20
Diet
OP50
Lifespan (days)
24.7
Lifespan change (compared to wild type)
30.69%
Phenotype
The ftt-1 RNAi didn't induce a significant life span modulation in comparison with control. This result is relevant to a negative modulation of pdk-1 activity by ftt-2 that can be highlighted here by a life span shortening effect upon RNAi.
Lifespan comparisons
Double mutant ftt-1(RNAi);pdk-1(sa709) has a lifespan of 24.7 days, while single mutant ftt-1(RNAi) has a lifespan of 16.4 days, single mutant pdk-1(sa709) has a lifespan of 21.5 days and wild type has a lifespan of 18.9 days.
Type of interaction
See methods
Enhancer, opposite lifespan effects
Citation
View abstract
Araiz C et al., 2008, 14-3-3 regulates life span by both DAF-16-dependent and -independent mechanisms in Caenorhabditis elegans. Exp Gerontol. 43(6):505-19 18423931 Click here to select all mutants from this PubMed ID in the graph
Abstract
Caenorhabditis elegans life span, stress resistance and metabolism are regulated by the Insulin/IGF-1/DAF-2/DAF-16 pathway. DAF-16, a member of FOXO/Forkhead transcription factor family, can be targeted by 14-3-3 proteins to promote stress resistance. We have identified a 14-3-3 C. elegans homolog which promotes life span by both DAF-2-dependent and -independent mechanisms and by an unexpected DAF-16-independent mechanism. Our results demonstrate that C. elegans 14-3-3 proteins modulate stress-responsive genes throughout adulthood. In conclusion, 14-3-3 can be considered as an acute stress-responsive regulator as well as a sustained modulator of the Insulin/IGF-1/DAF-2/DAF-16 regulatory pathway in promoting life expectancy of growing old worms.

Search genes: ftt-1 pdk-1

Symbol
GenAge

ftt-1
View on GenAge (ftt-1)

No gene information for ftt-1

Entrez ID
Symbol
GenAge
Wormbase ID

180475
pdk-1
View on GenAge (pdk-1)
WBGene00003965

3-phosphoinositide-dependent protein kinase 1

Locus: CELE_H42K12.1

Wormbase description: pdk-1 encodes the C. elegans 3-phosphoinositide-dependent kinase 1 ortholog; PDK-1 is a component of the DAF-2/insulin receptor-like signaling pathway and accordingly, functions to regulate such processes as dauer larvae formation, longevity, and salt chemotaxis learning; genetic analyses indicate that, in regulating dauer arrest, PDK-1 acts downstream of AGE-1/PI3K and upstream of the AKT-1 and AKT-2 kinases; a PDK-1::GFP fusion protein is expressed broadly beginning in late stage embryos and continuing on through adulthood; expression is seen in head, tail, and ventral cord motor neurons, pharyngeal tissues, hypodermal cells, the intestine, and the somatic gonad; in neurons, the PDK-1::GFP localizes to cell bodies and processes, with occasional expression seen in some neuronal nuclei.

Orthologs of ftt-1;pdk-1 in SynergyAge

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Species	Gene

Not in SynergyAge
Species	Gene

Orthologs of ftt-1 in SynergyAge

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Species	Gene

Orthologs of pdk-1 in SynergyAge

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Species	Gene

Not in SynergyAge
Species	Gene
Drosophila melanogaster	Pdk1
Mus musculus	Pdpk1