daf-16;ftt-1

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Genetic mutants with daf-16, ftt-1 alterations

Names of genes are ordered alphabetically. For the order of interventions, please see the specific paper.

Temperature °C
20
Diet
OP50
Lifespan (days)
14.0
Lifespan change (compared to wild type)
-25.93%
Phenotype
The ftt-1 gene doesn't modulate life span in daf-16 loss-of-function genetic background.
Lifespan comparisons
Double mutant daf-16(mgDf50);ftt-1(RNAi) has a lifespan of 14.0 days, while single mutant ftt-1(RNAi) has a lifespan of 16.4 days, single mutant daf-16(mgDf50) has a lifespan of 13.9 days and wild type has a lifespan of 18.9 days.
Type of interaction
See methods
Dependent
Citation
View abstract
Araiz C et al., 2008, 14-3-3 regulates life span by both DAF-16-dependent and -independent mechanisms in Caenorhabditis elegans. Exp Gerontol. 43(6):505-19 18423931 Click here to select all mutants from this PubMed ID in the graph
Abstract
Caenorhabditis elegans life span, stress resistance and metabolism are regulated by the Insulin/IGF-1/DAF-2/DAF-16 pathway. DAF-16, a member of FOXO/Forkhead transcription factor family, can be targeted by 14-3-3 proteins to promote stress resistance. We have identified a 14-3-3 C. elegans homolog which promotes life span by both DAF-2-dependent and -independent mechanisms and by an unexpected DAF-16-independent mechanism. Our results demonstrate that C. elegans 14-3-3 proteins modulate stress-responsive genes throughout adulthood. In conclusion, 14-3-3 can be considered as an acute stress-responsive regulator as well as a sustained modulator of the Insulin/IGF-1/DAF-2/DAF-16 regulatory pathway in promoting life expectancy of growing old worms.

Temperature °C
22.5
Diet
OP50
Lifespan (days)
8.7
Lifespan change (compared to wild type)
-54.21%
Phenotype
The ftt-1 gene doesn't modulate life span in daf-16 loss-of-function genetic background.
Lifespan comparisons
Double mutant daf-16(mgDf50);ftt-1(RNAi) has a lifespan of 8.7 days, while single mutant ftt-1(RNAi) has a lifespan of 16.4 days, single mutant daf-16(mgDf50) has a lifespan of 13.0 days and wild type has a lifespan of 19.0 days.
Type of interaction
See methods
Synergistic (negative)
Citation
View abstract
Araiz C et al., 2008, 14-3-3 regulates life span by both DAF-16-dependent and -independent mechanisms in Caenorhabditis elegans. Exp Gerontol. 43(6):505-19 18423931 Click here to select all mutants from this PubMed ID in the graph
Abstract
Caenorhabditis elegans life span, stress resistance and metabolism are regulated by the Insulin/IGF-1/DAF-2/DAF-16 pathway. DAF-16, a member of FOXO/Forkhead transcription factor family, can be targeted by 14-3-3 proteins to promote stress resistance. We have identified a 14-3-3 C. elegans homolog which promotes life span by both DAF-2-dependent and -independent mechanisms and by an unexpected DAF-16-independent mechanism. Our results demonstrate that C. elegans 14-3-3 proteins modulate stress-responsive genes throughout adulthood. In conclusion, 14-3-3 can be considered as an acute stress-responsive regulator as well as a sustained modulator of the Insulin/IGF-1/DAF-2/DAF-16 regulatory pathway in promoting life expectancy of growing old worms.

Search genes: daf-16 ftt-1

Entrez ID
Symbol
GenAge
Wormbase ID

172981
daf-16
View on GenAge (daf-16)
WBGene00000912

Forkhead box protein O;hypothetical protein

Locus: CELE_R13H8.1

Wormbase description: daf-16 encodes the sole C. elegans forkhead box O (FOXO) homologue; DAF-16 functions as a transcription factor that acts in the insulin/IGF-1-mediated signaling (IIS) pathway that regulates dauer formation, longevity, fat metabolism, stress response, and innate immunity; DAF-16 regulates these various processes through isoform-specific expression, isoform-specific regulation by different AKT kinases, and differential regulation of target genes; DAF-16 can interact with the CBP-1 transcription cofactor in vitro, and interacts genetically with other genes in the insulin signaling and with daf-12, which encodes a nuclear hormone receptor; DAF-16 is activated in response to DNA damage during development and co-regulated by EGL-27, alleviates DNA-damage-induced developmental arrest by inducing DAF-16-associated element (DAE)-regulated genes; DAF-16 is broadly expressed but displays isoform-specific tissue enrichment; DAF-16 localizes to both the cytoplasm and the nucleus, with the ratio between the two an important regulator of function.

Symbol
GenAge

ftt-1
View on GenAge (ftt-1)

No gene information for ftt-1

Orthologs of daf-16;ftt-1 in SynergyAge

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Species	Gene

Not in SynergyAge
Species	Gene

Orthologs of daf-16 in SynergyAge

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Species	Gene

Not in SynergyAge
Species	Gene
Mus musculus	Foxo6
Mus musculus	Foxo1
Mus musculus	Foxo4
Mus musculus	Foxo3

Orthologs of ftt-1 in SynergyAge

Show in SynergyAge
Species	Gene