daf-16;rrf3

There is no network for this step.

Fullscreen mode

Hide graph

Legend

Genetic mutants with daf-16, rrf3 alterations

Names of genes are ordered alphabetically. For the order of interventions, please see the specific paper.

Temperature °C
25
Lifespan (days)
11.36
Lifespan change (compared to wild type)
-18.39%
Phenotype
daf-16, and hsf-1 RNAi, the effect of cbp-1 RNAi to increase mortality in standard conditions is completely age-dependent, occurring only after midlife, and entails a doubling of the age-dependent acceleration of mortality rate without influencing initial mortality rate, inconsistent with age-independent general sickness.
Lifespan comparisons
Double mutant daf-16(RNAi);rrf3(pk1426) has a lifespan of 11.36 days, while single mutant daf-16(RNAi) has a lifespan of 10.67 days, single mutant rrf3(pk1426) has a lifespan of 15.38 days and wild type has a lifespan of 13.92 days.
Type of interaction
See methods
Opposite lifespan effects of single mutants
Citation
View abstract
Zhang M et al., 2009, Role of CBP and SATB-1 in aging, dietary restriction, and insulin-like signaling. PLoS Biol. 7(11):e1000245 19924292 Click here to select all mutants from this PubMed ID in the graph
Abstract
How dietary restriction (DR) increases lifespan and decreases disease burden are questions of major interest in biomedical research. Here we report that hypothalamic expression of CREB-binding protein (CBP) and CBP-binding partner Special AT-rich sequence binding protein 1 (SATB-1) is highly correlated with lifespan across five strains of mice, and expression of these genes decreases with age and diabetes in mice. Furthermore, in Caenorhabditis elegans, cbp-1 is induced by bacterial dilution DR (bDR) and the daf-2 mutation, and cbp-1 RNAi specifically in adults completely blocks lifespan extension by three distinct protocols of DR, partially blocks lifespan extension by the daf-2 mutation but not of cold, and blocks delay of other age-related pathologies by bDR. Inhibiting the C. elegans ortholog of SATB-1 and CBP-binding partners daf-16 and hsf-1 also attenuates lifespan extension by bDR, but not other protocols of DR. In a transgenic Abeta42 model of Alzheimer's disease, cbp-1 RNAi prevents protective effects of bDR and accelerates Abeta42-related pathology. Furthermore, consistent with the function of CBP as a histone acetyltransferase, drugs that enhance histone acetylation increase lifespan and reduce Abeta42-related pathology, protective effects completely blocked by cbp-1 RNAi. Other factors implicated in lifespan extension are also CBP-binding partners, suggesting that CBP constitutes a common factor in the modulation of lifespan and disease burden by DR and the insulin/IGF1 signaling pathway.

Temperature °C
20
Lifespan (days)
14.65
Lifespan change (compared to wild type)
-23.38%
Lifespan comparisons
Double mutant daf-16(RNAi);rrf3(pk1426) has a lifespan of 14.65 days, while single mutant rrf3(pk1426) has a lifespan of 21.7 days and wild type has a lifespan of 19.12 days.
Type of interaction
See methods
Contains dependence
Citation
View abstract
Zhang M et al., 2009, Role of CBP and SATB-1 in aging, dietary restriction, and insulin-like signaling. PLoS Biol. 7(11):e1000245 19924292 Click here to select all mutants from this PubMed ID in the graph
Abstract
How dietary restriction (DR) increases lifespan and decreases disease burden are questions of major interest in biomedical research. Here we report that hypothalamic expression of CREB-binding protein (CBP) and CBP-binding partner Special AT-rich sequence binding protein 1 (SATB-1) is highly correlated with lifespan across five strains of mice, and expression of these genes decreases with age and diabetes in mice. Furthermore, in Caenorhabditis elegans, cbp-1 is induced by bacterial dilution DR (bDR) and the daf-2 mutation, and cbp-1 RNAi specifically in adults completely blocks lifespan extension by three distinct protocols of DR, partially blocks lifespan extension by the daf-2 mutation but not of cold, and blocks delay of other age-related pathologies by bDR. Inhibiting the C. elegans ortholog of SATB-1 and CBP-binding partners daf-16 and hsf-1 also attenuates lifespan extension by bDR, but not other protocols of DR. In a transgenic Abeta42 model of Alzheimer's disease, cbp-1 RNAi prevents protective effects of bDR and accelerates Abeta42-related pathology. Furthermore, consistent with the function of CBP as a histone acetyltransferase, drugs that enhance histone acetylation increase lifespan and reduce Abeta42-related pathology, protective effects completely blocked by cbp-1 RNAi. Other factors implicated in lifespan extension are also CBP-binding partners, suggesting that CBP constitutes a common factor in the modulation of lifespan and disease burden by DR and the insulin/IGF1 signaling pathway.

Search genes: daf-16 rrf3

Entrez ID
Symbol
GenAge
Wormbase ID

172981
daf-16
View on GenAge (daf-16)
WBGene00000912

Forkhead box protein O;hypothetical protein

Locus: CELE_R13H8.1

Wormbase description: daf-16 encodes the sole C. elegans forkhead box O (FOXO) homologue; DAF-16 functions as a transcription factor that acts in the insulin/IGF-1-mediated signaling (IIS) pathway that regulates dauer formation, longevity, fat metabolism, stress response, and innate immunity; DAF-16 regulates these various processes through isoform-specific expression, isoform-specific regulation by different AKT kinases, and differential regulation of target genes; DAF-16 can interact with the CBP-1 transcription cofactor in vitro, and interacts genetically with other genes in the insulin signaling and with daf-12, which encodes a nuclear hormone receptor; DAF-16 is activated in response to DNA damage during development and co-regulated by EGL-27, alleviates DNA-damage-induced developmental arrest by inducing DAF-16-associated element (DAE)-regulated genes; DAF-16 is broadly expressed but displays isoform-specific tissue enrichment; DAF-16 localizes to both the cytoplasm and the nucleus, with the ratio between the two an important regulator of function.

Symbol
GenAge

rrf3
View on GenAge (rrf3)

No gene information for rrf3

Orthologs of daf-16;rrf3 in SynergyAge

Show in SynergyAge
Species	Gene

Not in SynergyAge
Species	Gene

Orthologs of daf-16 in SynergyAge

Show in SynergyAge
Species	Gene

Not in SynergyAge
Species	Gene
Mus musculus	Foxo6
Mus musculus	Foxo1
Mus musculus	Foxo4
Mus musculus	Foxo3

Orthologs of rrf3 in SynergyAge

Show in SynergyAge
Species	Gene