akt-1;eak-4

Lifespan changes: From wild type to akt-1;eak-4

There is no network for this step.
Fullscreen mode
Hide graph
Legend

Genetic mutants with akt-1, eak-4 alterations

    Names of genes are ordered alphabetically. For the order of interventions, please see the specific paper.
  • Temperature °C

    25

  • Diet

    NGM

  • Lifespan (days)

    13.25

  • Lifespan change (compared to wild type)

    1.92%

  • Phenotype

    The eak alleles did not enhance life span extension of akt-1(mg306), although they all strongly enhanced the dauer formation phenotype of akt-1(mg306).

  • Lifespan comparisons

    Double mutant akt-1(mg306);eak-4(mg348) has a lifespan of 13.25 days, while single mutant eak-4(mg348) has a lifespan of 13.5 days, single mutant akt-1(mg306) has a lifespan of 15.0 days and wild type has a lifespan of 13.0 days.

  • Type of interaction
    See methods

    Antagonistic (positive)

  • Citation
    View abstract

    Hu PJ et al., 2006, Two membrane-associated tyrosine phosphatase homologs potentiate C. elegans AKT-1/PKB signaling. PLoS Genet. 2(7):e99 PubMed 16839187 Click here to select all mutants from this PubMed ID in the graph

  • Temperature °C

    20

  • Lifespan (days)

    13.1

  • Lifespan change (compared to wild type)

    3.15%

  • Phenotype

    Double mutants had lifespans comparable to WT.

  • Lifespan comparisons

    Double mutant akt-1(mg306);eak-4(mg348) has a lifespan of 13.1 days, while single mutant akt-1(mg306) has a lifespan of 13.7 days, single mutant eak-4(mg348) has a lifespan of 12.9 days and wild type has a lifespan of 12.7 days.

  • Type of interaction
    See methods

    Dependent

  • Citation
    View abstract

    Zhang Y et al., 2008, Caenorhabditis elegans EAK-3 inhibits dauer arrest via nonautonomous regulation of nuclear DAF-16/FoxO activity. Dev Biol. 315(2):290-302 PubMed 18241854 Click here to select all mutants from this PubMed ID in the graph

Search genes: akt-1 eak-4
  • Entrez ID
  • Symbol
  • GenAge
  • Wormbase ID

Serine/threonine-protein kinase akt-1


Locus: CELE_C12D8.10


Wormbase description: akt-1 encodes an ortholog of the serine/threonine kinase Akt/PKB; akt-1 genetically interacts with the insulin signaling pathway and functions to regulate such processes as dauer larval development and salt chemotaxis learning; AKT-1 binds calmodulin in vitro in a calcium-dependent manner; an AKT-1::GFP fusion protein is widely expressed beginning in late stage embryos and continuing through adulthood; expression is seen in head, tail, and dorsal and ventral cord neurons, with additional expression seen in other cells including those of the pharynx, hypodermis, intestine, and spermatheca; two alleles of akt-1 (sa573 and sa700) have a Daf-c mutant phenotype at 27 degrees C (Hid phenotype).


  • Entrez ID
  • Symbol
  • GenAge
  • Wormbase ID

Protein eak-4


Locus: CELE_F53B2.3


Wormbase description: eak-4 encodes a novel protein that contains an N-myristoylation signal; eak-4 acts in parallel to akt-1 to regulate insulin-like signaling and dauer formation; EAK-4 is expressed primarily in the neuroendocrine XXXL/R cells, where it associates with the plasma membrane.


Orthologs of akt-1;eak-4 in SynergyAge
Show in SynergyAge
Species Gene
Orthologs of akt-1 in SynergyAge
Show in SynergyAge
Species Gene
Orthologs of eak-4 in SynergyAge
Show in SynergyAge
Species Gene
About

SynergyAge database hosts high-quality, manually curated information about the synergistic and antagonistic lifespan effects of genetic interventions in model organisms, also allowing users to explore the longevity relationships between genes in a visual way.

Read more about SynergyAge database

How to cite us

If you would like to cite this database please use:

Bunu, G., Toren, D., Ion, C. et al. SynergyAge, a curated database for synergistic and antagonistic interactions of longevity-associated genes. Sci Data 7, 366 (2020). https://doi.org/10.1038/s41597-020-00710-z

Contact
Robi Tacutu, Ph.D.
Head: Systems Biology of Aging Group, Bioinformatics & Structural Biochemistry Department
Institute of Biochemistry, Ground floor
Splaiul Independentei 296, Bucharest, Romania
Email:

Group webpage: www.aging-research.group