ctb-1;drp-1;isp-1

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Genetic mutants with ctb-1, drp-1, isp-1 alterations

Names of genes are ordered alphabetically. For the order of interventions, please see the specific paper.

Temperature °C
20
Lifespan (days)
26.9
Lifespan change (compared to wild type)
78.98%
Lifespan comparisons
Triple mutant ctb-1(qm189);drp-1(RNAi);isp-1(qm150) has a lifespan of 26.9 days, while single mutant drp-1(RNAi) has a lifespan of 15.54 days, double mutant ctb-1(qm189);isp-1(qm150) has a lifespan of 24.55 days and wild type has a lifespan of 15.03 days.
Citation
View abstract
Yang CC et al., 2011, The dynamin-related protein DRP-1 and the insulin signaling pathway cooperate to modulate Caenorhabditis elegans longevity. Aging Cell. 10(4):724-8 21463460 Click here to select all mutants from this PubMed ID in the graph
Abstract
Here, we report that inactivation of the Caenorhabditis elegans dynamin-related protein DRP-1, a key component responsible for mitochondrial fission and conserved from yeast to humans, dramatically enhanced the effect of reduced insulin signaling (IIS) to extend lifespan. This represents the first report of a beneficial impact of manipulating mitochondrial dynamics on animal lifespan and suggests that mitochondrial morphology and IIS cooperate to modulate aging.

Search genes: ctb-1 drp-1 isp-1 ctb-1;drp-1;isp-1

Symbol
GenAge

ctb-1
View on GenAge (ctb-1)

No gene information for ctb-1

Entrez ID
Symbol
GenAge
Wormbase ID

177336
drp-1
View on GenAge (drp-1)
WBGene00001093

Dynamin-Related Protein

Locus: CELE_T12E12.4

Wormbase description: drp-1 encodes a dynamin-related protein, orthologous to Dnm1p in S. cerevisiae and DRP1 in mammals, that is required for severing of the mitochondrial outer membrane during mitochondrial division.

Entrez ID
Symbol
GenAge
Wormbase ID

177609
isp-1
View on GenAge (isp-1)
WBGene00002162

Cytochrome b-c1 complex subunit Rieske, mitochondrial

Locus: CELE_F42G8.12

Wormbase description: isp-1 encodes a Rieske iron sulphur protein (ISP) which is a subunit of the mitochondrial complex III in the mitochondrial membrane; the subunits are highly conserved in all mitochondria and aerobic bacteria; mitochondrial complex III catalyses electron transport from ubiquinol to cytochrome c; isp-1 mutants show low oxygen consumption, a decreased sensitivity to reactive oxygen species and increased lifespan suggesting that mitochondrial electron transport is a key factor affecting life span; isp-1 affects the rates of physiological processes like reproduction and development and also affects behavior.

Orthologs of ctb-1;drp-1;isp-1 in SynergyAge

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Species	Gene

Not in SynergyAge
Species	Gene
Mus musculus	Uqcrfs1;Dnm1l

Orthologs of ctb-1 in SynergyAge

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Species	Gene

Orthologs of drp-1 in SynergyAge

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Species	Gene

Not in SynergyAge
Species	Gene
Drosophila melanogaster	Drp1
Mus musculus	Dnm1l

Orthologs of isp-1 in SynergyAge

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Species	Gene

Not in SynergyAge
Species	Gene
Mus musculus	Uqcrfs1

About

SynergyAge database hosts high-quality, manually curated information about the synergistic and antagonistic lifespan effects of genetic interventions in model organisms, also allowing users to explore the longevity relationships between genes in a visual way.