clk-1;drp-1

There is no network for this step.

Fullscreen mode

Hide graph

Legend

Genetic mutants with clk-1, drp-1 alterations

Names of genes are ordered alphabetically. For the order of interventions, please see the specific paper.

Temperature °C
20
Lifespan (days)
26.54
Lifespan change (compared to wild type)
76.58%
Phenotype
Inactivating drp-1 specifically and robustly synergizes with reduced IIS to prolong longevity.
Lifespan comparisons
Double mutant clk-1(e2519);drp-1(RNAi) has a lifespan of 26.54 days, while single mutant drp-1(RNAi) has a lifespan of 15.54 days, single mutant clk-1(e2519) has a lifespan of 24.6 days and wild type has a lifespan of 15.03 days.
Type of interaction
See methods
Synergistic (positive)
Citation
View abstract
Yang CC et al., 2011, The dynamin-related protein DRP-1 and the insulin signaling pathway cooperate to modulate Caenorhabditis elegans longevity. Aging Cell. 10(4):724-8 21463460 Click here to select all mutants from this PubMed ID in the graph
Abstract
Here, we report that inactivation of the Caenorhabditis elegans dynamin-related protein DRP-1, a key component responsible for mitochondrial fission and conserved from yeast to humans, dramatically enhanced the effect of reduced insulin signaling (IIS) to extend lifespan. This represents the first report of a beneficial impact of manipulating mitochondrial dynamics on animal lifespan and suggests that mitochondrial morphology and IIS cooperate to modulate aging.

Search genes: clk-1 drp-1

Entrez ID
Symbol
GenAge
Wormbase ID

175729
clk-1
View on GenAge (clk-1)
WBGene00000536

5-demethoxyubiquinone hydroxylase, mitochondrial

Locus: CELE_ZC395.2

Wormbase description: clk-1 encodes the C. elegans ortholog of COQ7/CAT5, a highly conserved demethoxyubiquinone (DMQ) hydroxylase that is necessary for the biosynthesis of ubiquinone (coenzyme Q, Q9) from 5-demethoxyubiquinone (DMQ9); in C. elegans, CLK-1 activity is required for normal physiological rates of growth, development, behavior, and aging, as well as for normal brood sizes.

Entrez ID
Symbol
GenAge
Wormbase ID

177336
drp-1
View on GenAge (drp-1)
WBGene00001093

Dynamin-Related Protein

Locus: CELE_T12E12.4

Wormbase description: drp-1 encodes a dynamin-related protein, orthologous to Dnm1p in S. cerevisiae and DRP1 in mammals, that is required for severing of the mitochondrial outer membrane during mitochondrial division.

Orthologs of clk-1;drp-1 in SynergyAge

Show in SynergyAge
Species	Gene

Not in SynergyAge
Species	Gene
Drosophila melanogaster	COQ7;Drp1
Mus musculus	Coq7;Dnm1l
Mus musculus	Dnm1l;Coq7

Orthologs of clk-1 in SynergyAge

Show in SynergyAge
Species	Gene

Not in SynergyAge
Species	Gene
Drosophila melanogaster	COQ7
Mus musculus	Coq7

Orthologs of drp-1 in SynergyAge

Show in SynergyAge
Species	Gene

Not in SynergyAge
Species	Gene
Drosophila melanogaster	Drp1
Mus musculus	Dnm1l

About

SynergyAge database hosts high-quality, manually curated information about the synergistic and antagonistic lifespan effects of genetic interventions in model organisms, also allowing users to explore the longevity relationships between genes in a visual way.