Lifespan changes: From wild type to akt-1;akt-2;jnk-1

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Genetic mutants with akt-1, akt-2, jnk-1 alterations

    Names of genes are ordered alphabetically. For the order of interventions, please see the specific paper.
  • Temperature °C


  • Lifespan (days)


  • Lifespan change (compared to wild type)


  • Phenotype

    lpIn1 strain shows a lifespan extension beyond the akt-1(ok525); akt-2(ok393) double mutant alone

  • Lifespan comparisons

    Triple mutant akt-1(ok525);akt-2(ok393);jnk-1(OE) has a lifespan of 38.8 days, while double mutant akt-1(ok525);akt-2(ok393) has a lifespan of 34.2 days and wild type has a lifespan of 14.9 days.

  • Citation
    View abstract

    Oh SW et al., 2005, JNK regulates lifespan in Caenorhabditis elegans by modulating nuclear translocation of forkhead transcription factor/DAF-16. Proc Natl Acad Sci U S A. 102(12):4494-9 PubMed 15767565 Click here to select all mutants from this PubMed ID in the graph

Search genes: akt-1 akt-2 jnk-1 akt-1;akt-2;jnk-1
  • Entrez ID
  • Symbol
  • GenAge
  • Wormbase ID

Serine/threonine-protein kinase akt-1

Locus: CELE_C12D8.10

Wormbase description: akt-1 encodes an ortholog of the serine/threonine kinase Akt/PKB; akt-1 genetically interacts with the insulin signaling pathway and functions to regulate such processes as dauer larval development and salt chemotaxis learning; AKT-1 binds calmodulin in vitro in a calcium-dependent manner; an AKT-1::GFP fusion protein is widely expressed beginning in late stage embryos and continuing through adulthood; expression is seen in head, tail, and dorsal and ventral cord neurons, with additional expression seen in other cells including those of the pharynx, hypodermis, intestine, and spermatheca; two alleles of akt-1 (sa573 and sa700) have a Daf-c mutant phenotype at 27 degrees C (Hid phenotype).

  • Entrez ID
  • Symbol
  • GenAge
  • Wormbase ID

Serine/threonine-protein kinase akt-2

Locus: CELE_F28H6.1

Wormbase description: akt-2 encodes a homolog of the serine/threonine kinase Akt/PKB, AKT-2, that is required for progression through the dauer stage of development and for the negative regulation of adult lifespan; inactivation of akt-2 causes animals to arrest constitutively at the dauer stage, while having an increased life span; widely expressed, AKT-2 is activated by the phospholipid products of phosphoinositide 3-kinase AGE-1/PI3K and by PDK-1, a homolog of vertebrate 3-phosphoinositide-dependent kinase-1 (PDK-1) Normal akt-2 (and akt-1) activity is required for excess pdk-1 activity to suppress the dauer-arrest phenotype of age-1, indicating that the 3-phosphoinositide-dependent kinase-1 homolog PDK-1 transduces signals from AGE-1 to AKT-2 (and AKT-1); conversely, the akt-2 loss-of-function phenotype is suppressed by daf-16 null mutations, indicating that the Fork head transcription factor DAF-16 is downstream of AKT-2 (and AKT-1), and that AKT-1 and AKT-2 act primarily to antagonize DAF-16.

  • Entrez ID
  • Symbol
  • GenAge
  • Wormbase ID

Stress-activated protein kinase jnk-1

Locus: CELE_B0478.1

Wormbase description: jnk-1 encodes a serine/threonine kinase that is the sole C. elegans member of the c-Jun N-terminal kinase (JNK) subgroup of mitogen-activated protein (MAP) kinases; jnk-1 is required for normal coordinated locomotion as well as for normal adult lifespan and response to heat and oxidative stress; JNK-1 exhibits kinase activity in vitro that is dependent upon activation by the JKK-1/MAPKK; in addition, JKK-1-dependent JNK-1 phosphorylation is required for JNK-1-mediated lifespan extension, as is DAF-16, with which JNK-1 physically interacts and phosphorylates and whose nuclear translocation is under JNK-1 control; a JNK-1::GFP translational fusion protein is expressed in nearly all neuronal cell bodies and processes, including the nerve ring, head and tail ganglions, and the dorsal and ventral nerve cords, at all stages of development.

Orthologs of akt-1;akt-2;jnk-1 in SynergyAge
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Orthologs of akt-1 in SynergyAge
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Species Gene
Orthologs of akt-2 in SynergyAge
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Species Gene
Orthologs of jnk-1 in SynergyAge
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Species Gene

SynergyAge database hosts high-quality, manually curated information about the synergistic and antagonistic lifespan effects of genetic interventions in model organisms, also allowing users to explore the longevity relationships between genes in a visual way.

Read more about SynergyAge database

How to cite us

If you would like to cite this database please use:

Bunu, G., Toren, D., Ion, C. et al. SynergyAge, a curated database for synergistic and antagonistic interactions of longevity-associated genes. Sci Data 7, 366 (2020). https://doi.org/10.1038/s41597-020-00710-z

Robi Tacutu, Ph.D.
Head: Systems Biology of Aging Group, Bioinformatics & Structural Biochemistry Department
Institute of Biochemistry, Ground floor
Splaiul Independentei 296, Bucharest, Romania

Group webpage: www.aging-research.group