Lifespan changes: From wild type to age-1;cst-1

There is no network for this step.
Fullscreen mode
Hide graph

Genetic mutants with age-1, cst-1 alterations

    Names of genes are ordered alphabetically. For the order of interventions, please see the specific paper.
  • Lifespan (days)


  • Lifespan change (compared to wild type)


  • Phenotype

    CST knockdown reduced life span to a similar extent in both N2 and DAF-2-deficient daf-2(e1368) C. elegans as well as in both age-1(hx546) and N2 nematodes

  • Lifespan comparisons

    Double mutant age-1(hx546);cst-1(RNAi) has a lifespan of 21.1 days, while single mutant age-1(hx546) has a lifespan of 24.8 days and wild type has a lifespan of 16.3 days.

  • Type of interaction
    See methods

    Contains dependence

  • Citation
    View abstract

    Lehtinen MK et al., 2006, A conserved MST-FOXO signaling pathway mediates oxidative-stress responses and extends life span. Cell. 125(5):987-1001 PubMed 16751106 Click here to select all mutants from this PubMed ID in the graph

Search genes: age-1 cst-1
  • Entrez ID
  • Symbol
  • GenAge
  • Wormbase ID

Phosphatidylinositol 3-kinase age-1;hypothetical protein

Locus: CELE_B0334.8

Wormbase description: age-1 encodes the C. elegans ortholog of the phosphoinositide 3-kinase (PI3K) p110 catalytic subunit; AGE-1, supplied maternally and embryonically, is a central component of the C. elegans insulin-like signaling pathway, lying downstream of the DAF-2/insulin receptor and upstream of both the PDK-1 and AKT-1/AKT-2 kinases and the DAF-16 forkhead type transcription factor, whose negative regulation is the key output of the insulin signaling pathway; in accordance with its role in insulin signaling, AGE-1 activity is required for regulation of metabolism, life span, dauer formation, stress resistance, salt chemotaxis learning, fertility, and embryonic development; although the age-1 expression pattern has not yet been reported, ectopic expression studies indicate that pan-neuronal age-1 expression is sufficient to rescue life-span defects, while neuronal, intestinal, or muscle expression can partially rescue dauer formation, and neuronal or muscle expression can rescue metabolic defects.

  • Entrez ID
  • Symbol
  • GenAge
  • Wormbase ID

Serine/threonine-protein kinase cst-1 37kDa subunit

Locus: CELE_F14H12.4

Wormbase description: cst-1 encodes one of two C. elegans protein kinases orthologous to the MST (mammalian Ste20-like) kinases and Drosophila Hippo; CST-1 appears to play a role in the responses to oxidative stress and determination of adult lifespan; in regulating stress response and lifespan, CST-1 functions upstream of the DAF-16/FOXO transcription factor; CST-1 physically interacts with RSF-1, the C. elegans homolog of the Ras-association domain family protein 1.

Orthologs of age-1;cst-1 in SynergyAge
Show in SynergyAge
Species Gene
Orthologs of age-1 in SynergyAge
Show in SynergyAge
Species Gene
Drosophila melanogaster Pi3K92E
Orthologs of cst-1 in SynergyAge
Show in SynergyAge
Species Gene

SynergyAge database hosts high-quality, manually curated information about the synergistic and antagonistic lifespan effects of genetic interventions in model organisms, also allowing users to explore the longevity relationships between genes in a visual way.

Read more about SynergyAge database

How to cite us

If you would like to cite this database please use:

Bunu, G., Toren, D., Ion, C. et al. SynergyAge, a curated database for synergistic and antagonistic interactions of longevity-associated genes. Sci Data 7, 366 (2020).

Robi Tacutu, Ph.D.
Head: Systems Biology of Aging Group, Bioinformatics & Structural Biochemistry Department
Institute of Biochemistry, Ground floor
Splaiul Independentei 296, Bucharest, Romania

Group webpage: