Lifespan changes: From wild type to daf-2;npr-1 / From daf-2;npr-1 to multiple mutants
21
live OP50
31.74
129.17%
The lifespan of daf-2(e1370) mutants was not further extended by npr-1 loss of function, suggesting that lifespan lengthening by inhibition of daf-2 and npr-1 takes place through overlapping mechanisms.
Double mutant daf-2(e1370);npr-1(ad609) has a lifespan of 31.74 days, while single mutant npr-1(ad609) has a lifespan of 15.18 days, single mutant daf-2(e1370) has a lifespan of 30.82 days and wild type has a lifespan of 13.85 days.
Almost additive (positive)
Abergel R et al., 2017, Synergism between soluble guanylate cyclase signaling and neuropeptides extends lifespan in the nematode Caenorhabditis elegans. Aging Cell. 16(2):401-413 28054425 Click here to select all mutants from this PubMed ID in the graph
21
live OP50
33.86
150.63%
The lifespan of daf-2(e1370) mutants was not further extended by npr-1 loss of function, suggesting that lifespan lengthening by inhibition of daf-2 and npr-1 takes place through overlapping mechanisms.
Double mutant daf-2(e1370);npr-1(ad609) has a lifespan of 33.86 days, while single mutant npr-1(ad609) has a lifespan of 16.48 days, single mutant daf-2(e1370) has a lifespan of 31.39 days and wild type has a lifespan of 13.51 days.
Almost additive (positive)
Abergel R et al., 2017, Synergism between soluble guanylate cyclase signaling and neuropeptides extends lifespan in the nematode Caenorhabditis elegans. Aging Cell. 16(2):401-413 28054425 Click here to select all mutants from this PubMed ID in the graph
21
live OP50
25.06
88.99%
The lifespan of daf-2(e1370) mutants was not further extended by npr-1 loss of function, suggesting that lifespan lengthening by inhibition of daf-2 and npr-1 takes place through overlapping mechanisms.
Double mutant daf-2(e1370);npr-1(ad609) has a lifespan of 25.06 days, while single mutant npr-1(ad609) has a lifespan of 15.0 days, single mutant daf-2(e1370) has a lifespan of 31.68 days and wild type has a lifespan of 13.26 days.
Dependent
Abergel R et al., 2017, Synergism between soluble guanylate cyclase signaling and neuropeptides extends lifespan in the nematode Caenorhabditis elegans. Aging Cell. 16(2):401-413 28054425 Click here to select all mutants from this PubMed ID in the graph
Insulin-like receptor subunit beta;Receptor protein-tyrosine kinase;hypothetical protein
Locus: CELE_Y55D5A.5
Wormbase description: daf-2 encodes a receptor tyrosine kinase that is the C. elegans insulin/IGF receptor ortholog; DAF-2 activity is required for a number of processes in C. elegans, including embryonic and larval development, formation of the developmentally arrested dauer larval stage (diapause), larval developmental timing, adult longevity, reproduction, fat storage, salt chemotaxis learning, and stress resistance, including response to high temperature, oxidative stress, and bacterial infection; DAF-2 signals through a conserved PI 3-kinase pathway to negatively regulate the activity of DAF-16, a Forkhead-related transcription factor, by inducing its phosphorylation and nuclear exclusion; in addition, DAF-2 negatively regulates the nuclear localization, and hence transcriptional activity, of SKN-1 in intestinal nuclei; amongst the 38 predicted insulin-like molecules in C. elegans, genetic and microarray analyses suggest that at least DAF-28, INS-1, and INS-7 are likely DAF-2 ligands; genetic mosaic and tissue-specific promoter studies indicate that daf-2 can function cell nonautonomously and within multiple cell types to influence dauer formation and adult lifespan, likely by regulating the production of secondary endocrine signals that coordinate growth and longevity throughout the animal; temporal analysis of daf-2 function indicates that daf-2 regulates lifespan, reproduction, and diapause independently, at distinct times during the animal's life cycle.
NeuroPeptide Receptor family
Locus: CELE_C39E6.6
Wormbase description: npr-1 encodes a predicted G protein-coupled neuropeptide receptor that is homologous to the mammalian neuropeptide Y (NPY) receptor (OMIM:162641) required for regulating anxiety, food consumption, and pain sensation; in C. elegans, NPR-1 is involved in ethological variations of social behavior such as social versus solitary feeding; in regulating social behavior, NPR-1 functions as a receptor for the FLP-18 and FLP-21 peptide ligands; NPR-1 also affects some aspect of UNC-6/netrin-mediated branching of motor neurons, as strong npr-1 mutations can suppress abnormal migration of ventral nerve cord neurons induced by overexpression of UNC-6 lacking domain C; NPR-1 is expressed predominantly in the nervous system, and particularly in the AQR, PQR, and URX neurons that are exposed to the body fluid.
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Drosophila melanogaster | InR |
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SynergyAge database hosts high-quality, manually curated information about the synergistic and antagonistic lifespan effects of genetic interventions in model organisms, also allowing users to explore the longevity relationships between genes in a visual way.
If you would like to cite this database please use:
Bunu, G., Toren, D., Ion, C. et al. SynergyAge, a curated database for synergistic and antagonistic interactions of longevity-associated genes. Sci Data 7, 366 (2020). https://doi.org/10.1038/s41597-020-00710-z
Group webpage: www.aging-research.group