atg-4.1;daf-2

Lifespan changes: From wild type to atg-4.1;daf-2

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Genetic mutants with atg-4.1, daf-2 alterations

    Names of genes are ordered alphabetically. For the order of interventions, please see the specific paper.
  • Temperature °C

    20

  • Lifespan (days)

    37.3

  • Lifespan change (compared to wild type)

    74.30%

  • Lifespan comparisons

    Double mutant atg-4.1(RNAi);daf-2(e1370) has a lifespan of 37.3 days, while single mutant atg-4.1(RNAi) has a lifespan of 18.5 days, single mutant daf-2(e1370) has a lifespan of 34.6 days and wild type has a lifespan of 21.4 days.

  • Type of interaction
    See methods

    Enhancer, opposite lifespan effects

  • Citation
    View abstract

    Hashimoto Y et al., 2009, Lifespan extension by suppression of autophagy genes in Caenorhabditis elegans. Genes Cells. 14(6):717-26 PubMed 19469880 Click here to select all mutants from this PubMed ID in the graph

  • Temperature °C

    20

  • Lifespan (days)

    37.1

  • Lifespan change (compared to wild type)

    69.41%

  • Lifespan comparisons

    Double mutant atg-4.1(RNAi);daf-2(e1370) has a lifespan of 37.1 days, while single mutant atg-4.1(RNAi) has a lifespan of 22.0 days, single mutant daf-2(e1370) has a lifespan of 38.1 days and wild type has a lifespan of 21.9 days.

  • Type of interaction
    See methods

    Dependent

  • Citation
    View abstract

    Hashimoto Y et al., 2009, Lifespan extension by suppression of autophagy genes in Caenorhabditis elegans. Genes Cells. 14(6):717-26 PubMed 19469880 Click here to select all mutants from this PubMed ID in the graph

Search genes: atg-4.1 daf-2
  • Entrez ID
  • Symbol
  • GenAge
  • Wormbase ID

Cysteine protease


Locus: CELE_Y87G2A.3


Wormbase description: atg-4.1 encodes a putative cysteine protease orthologous to the autophagic budding yeast protein Atg4p, and to human ATG4A and ATG4B; ATG-4.1 is paralogous to ATG-4.2 and to human ATG4C (OMIM:611339) and ATG4D (OMIM:611340); ATG-4.1 is expressed from early embryos to adults, in larval and adult intestine, renal gland cells, and neurons; ATG-4.1 exhibits protease activity towards LGG-1; ATG-4.1 localizes to the cytoplasm of most cells during embryogenesis.


  • Entrez ID
  • Symbol
  • GenAge
  • Wormbase ID

Insulin-like receptor subunit beta;Receptor protein-tyrosine kinase;hypothetical protein


Locus: CELE_Y55D5A.5


Wormbase description: daf-2 encodes a receptor tyrosine kinase that is the C. elegans insulin/IGF receptor ortholog; DAF-2 activity is required for a number of processes in C. elegans, including embryonic and larval development, formation of the developmentally arrested dauer larval stage (diapause), larval developmental timing, adult longevity, reproduction, fat storage, salt chemotaxis learning, and stress resistance, including response to high temperature, oxidative stress, and bacterial infection; DAF-2 signals through a conserved PI 3-kinase pathway to negatively regulate the activity of DAF-16, a Forkhead-related transcription factor, by inducing its phosphorylation and nuclear exclusion; in addition, DAF-2 negatively regulates the nuclear localization, and hence transcriptional activity, of SKN-1 in intestinal nuclei; amongst the 38 predicted insulin-like molecules in C. elegans, genetic and microarray analyses suggest that at least DAF-28, INS-1, and INS-7 are likely DAF-2 ligands; genetic mosaic and tissue-specific promoter studies indicate that daf-2 can function cell nonautonomously and within multiple cell types to influence dauer formation and adult lifespan, likely by regulating the production of secondary endocrine signals that coordinate growth and longevity throughout the animal; temporal analysis of daf-2 function indicates that daf-2 regulates lifespan, reproduction, and diapause independently, at distinct times during the animal's life cycle.


Orthologs of atg-4.1;daf-2 in SynergyAge
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Species Gene
Orthologs of atg-4.1 in SynergyAge
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Species Gene
Orthologs of daf-2 in SynergyAge
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Species Gene
Drosophila melanogaster InR
About

SynergyAge database hosts high-quality, manually curated information about the synergistic and antagonistic lifespan effects of genetic interventions in model organisms, also allowing users to explore the longevity relationships between genes in a visual way.

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How to cite us

If you would like to cite this database please use:

Bunu, G., Toren, D., Ion, C. et al. SynergyAge, a curated database for synergistic and antagonistic interactions of longevity-associated genes. Sci Data 7, 366 (2020). https://doi.org/10.1038/s41597-020-00710-z

Contact
Robi Tacutu, Ph.D.
Head: Systems Biology of Aging Group, Bioinformatics & Structural Biochemistry Department
Institute of Biochemistry, Ground floor
Splaiul Independentei 296, Bucharest, Romania
Email:

Group webpage: www.aging-research.group