Lifespan changes: From wild type to daf-10;daf-2
20
37.2
97.87%
The double mutants did not live longer than the daf-2(e1370) single mutant; instead, unexpectedly, their lifespans were slightly shorter than those of daf-2(e1370). Thus, we infer that the cilium-structure mutants do not act exclusively in a daf-2-independent pathway. To reconcile these findings, we propose the model that sensory neurons do act in a daf-2-dependent pathway, but that they also affect the animal in another way. Specifically, we suggest that an environmental signal perceived by sensory cilia regulates a DAF-2 ligand.
Double mutant daf-10(m79);daf-2(e1370) has a lifespan of 37.2 days, while single mutant daf-2(e1370) has a lifespan of 49.2 days and wild type has a lifespan of 18.8 days.
Dependent
Apfeld J, Kenyon C, 1999, Regulation of lifespan by sensory perception in Caenorhabditis elegans. Nature. 402(6763):804-9 
10617200
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Intraflagellar transport protein 122 homolog
Locus: CELE_F23B2.4
Wormbase description: daf-10 encodes a WD- and WAA-repeat containing protein that is the C. elegans ortholog of intraflagellar transport (IFT) complex A component IFT122; daf-10 activity is required for intraflagellar transport and thus for proper development of amphid and phasmid neurons, dauer development, chemotaxis, and normal lifespan; a DAF-10::GFP fusion protein undergoes both anterograde and retrograde intraflagellar transport in amphid or phasmid sensory neurons.
Insulin-like receptor subunit beta;Receptor protein-tyrosine kinase;hypothetical protein
Locus: CELE_Y55D5A.5
Wormbase description: daf-2 encodes a receptor tyrosine kinase that is the C. elegans insulin/IGF receptor ortholog; DAF-2 activity is required for a number of processes in C. elegans, including embryonic and larval development, formation of the developmentally arrested dauer larval stage (diapause), larval developmental timing, adult longevity, reproduction, fat storage, salt chemotaxis learning, and stress resistance, including response to high temperature, oxidative stress, and bacterial infection; DAF-2 signals through a conserved PI 3-kinase pathway to negatively regulate the activity of DAF-16, a Forkhead-related transcription factor, by inducing its phosphorylation and nuclear exclusion; in addition, DAF-2 negatively regulates the nuclear localization, and hence transcriptional activity, of SKN-1 in intestinal nuclei; amongst the 38 predicted insulin-like molecules in C. elegans, genetic and microarray analyses suggest that at least DAF-28, INS-1, and INS-7 are likely DAF-2 ligands; genetic mosaic and tissue-specific promoter studies indicate that daf-2 can function cell nonautonomously and within multiple cell types to influence dauer formation and adult lifespan, likely by regulating the production of secondary endocrine signals that coordinate growth and longevity throughout the animal; temporal analysis of daf-2 function indicates that daf-2 regulates lifespan, reproduction, and diapause independently, at distinct times during the animal's life cycle.
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| Drosophila melanogaster | InR |
SynergyAge database hosts high-quality, manually curated information about the synergistic and antagonistic lifespan effects of genetic interventions in model organisms, also allowing users to explore the longevity relationships between genes in a visual way.
If you would like to cite this database please use:
Bunu, G., Toren, D., Ion, C. et al. SynergyAge, a curated database for synergistic and antagonistic interactions of longevity-associated genes. Sci Data 7, 366 (2020). https://doi.org/10.1038/s41597-020-00710-z
Group webpage: www.aging-research.group
