daf-2;nmur-1

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Genetic mutants with daf-2, nmur-1 alterations

Names of genes are ordered alphabetically. For the order of interventions, please see the specific paper.

Temperature °C
25
Diet
OP50
Lifespan (days)
36.7
Lifespan change (compared to wild type)
216.38%
Phenotype
Removing nmur-1 does not significantly increase the lifespan of insulin/IGF-1 receptor daf-2 mutant worms.
Lifespan comparisons
Double mutant daf-2(e1370);nmur-1(ok1387) has a lifespan of 36.7 days, while single mutant nmur-1(ok1387) has a lifespan of 15.3 days, single mutant daf-2(e1370) has a lifespan of 33.3 days and wild type has a lifespan of 11.6 days.
Type of interaction
See methods
Almost additive (positive)
Citation
View abstract
Maier W et al., 2010, A neuromedin U receptor acts with the sensory system to modulate food type-dependent effects on C. elegans lifespan. PLoS Biol. 8(5):e1000376 20520844 Click here to select all mutants from this PubMed ID in the graph
Abstract
The type of food source has previously been shown to be as important as the level of food intake in influencing lifespan. Here we report that different Escherichia coli food sources alter Caenorhabditis elegans lifespan. These effects are modulated by different subsets of sensory neurons, which act with nmur-1, a homolog of mammalian neuromedin U receptors. Wild-type nmur-1, which is expressed in the somatic gonad, sensory neurons, and interneurons, shortens lifespan only on specific E. coli food sources-an effect that is dependent on the type of E. coli lipopolysaccharide structure. Moreover, the food type-dependent effect of nmur-1 on lifespan is different from that of food-level restriction. Together our data suggest that nmur-1 processes information from specific food cues to influence lifespan and other aspects of physiology.

Temperature °C
25
Diet
OP50
Lifespan (days)
24.4
Lifespan change (compared to wild type)
106.78%
Phenotype
Removing nmur-1 does not significantly increase the lifespan of insulin/IGF-1 receptor daf-2 mutant worms.
Lifespan comparisons
Double mutant daf-2(e1370);nmur-1(ok1387) has a lifespan of 24.4 days, while single mutant nmur-1(ok1387) has a lifespan of 14.8 days, single mutant daf-2(e1370) has a lifespan of 21.0 days and wild type has a lifespan of 11.8 days.
Type of interaction
See methods
Almost additive (positive)
Citation
View abstract
Maier W et al., 2010, A neuromedin U receptor acts with the sensory system to modulate food type-dependent effects on C. elegans lifespan. PLoS Biol. 8(5):e1000376 20520844 Click here to select all mutants from this PubMed ID in the graph
Abstract
The type of food source has previously been shown to be as important as the level of food intake in influencing lifespan. Here we report that different Escherichia coli food sources alter Caenorhabditis elegans lifespan. These effects are modulated by different subsets of sensory neurons, which act with nmur-1, a homolog of mammalian neuromedin U receptors. Wild-type nmur-1, which is expressed in the somatic gonad, sensory neurons, and interneurons, shortens lifespan only on specific E. coli food sources-an effect that is dependent on the type of E. coli lipopolysaccharide structure. Moreover, the food type-dependent effect of nmur-1 on lifespan is different from that of food-level restriction. Together our data suggest that nmur-1 processes information from specific food cues to influence lifespan and other aspects of physiology.

Search genes: daf-2 nmur-1

Entrez ID
Symbol
GenAge
Wormbase ID

175410
daf-2
View on GenAge (daf-2)
WBGene00000898

Insulin-like receptor subunit beta;Receptor protein-tyrosine kinase;hypothetical protein

Locus: CELE_Y55D5A.5

Wormbase description: daf-2 encodes a receptor tyrosine kinase that is the C. elegans insulin/IGF receptor ortholog; DAF-2 activity is required for a number of processes in C. elegans, including embryonic and larval development, formation of the developmentally arrested dauer larval stage (diapause), larval developmental timing, adult longevity, reproduction, fat storage, salt chemotaxis learning, and stress resistance, including response to high temperature, oxidative stress, and bacterial infection; DAF-2 signals through a conserved PI 3-kinase pathway to negatively regulate the activity of DAF-16, a Forkhead-related transcription factor, by inducing its phosphorylation and nuclear exclusion; in addition, DAF-2 negatively regulates the nuclear localization, and hence transcriptional activity, of SKN-1 in intestinal nuclei; amongst the 38 predicted insulin-like molecules in C. elegans, genetic and microarray analyses suggest that at least DAF-28, INS-1, and INS-7 are likely DAF-2 ligands; genetic mosaic and tissue-specific promoter studies indicate that daf-2 can function cell nonautonomously and within multiple cell types to influence dauer formation and adult lifespan, likely by regulating the production of secondary endocrine signals that coordinate growth and longevity throughout the animal; temporal analysis of daf-2 function indicates that daf-2 regulates lifespan, reproduction, and diapause independently, at distinct times during the animal's life cycle.

Entrez ID
Symbol
GenAge
Wormbase ID

183574
nmur-1
View on GenAge (nmur-1)
WBGene00016747

NMUR (NeuroMedin U Receptor) homolog

Locus: CELE_C48C5.1

Wormbase description: none available

Orthologs of daf-2;nmur-1 in SynergyAge

Show in SynergyAge
Species	Gene

Not in SynergyAge
Species	Gene

Orthologs of daf-2 in SynergyAge

Show in SynergyAge
Species	Gene
Drosophila melanogaster	InR

Not in SynergyAge
Species	Gene
Mus musculus	Insr
Mus musculus	Igf1r
Mus musculus	Insrr

Orthologs of nmur-1 in SynergyAge

Show in SynergyAge
Species	Gene