Lifespan changes: From wild type to daf-2;scl-1
20
19.0
34.75%
The life span of scl-1 RNAi-treated daf-2(e1370), namely daf-2; scl-1(RNAi), was reduced by about 80% compared with the non-RNAi-treated daf-2(e1370) and became similar to that of non-RNAi-treated N2. Therefore, scl-1 is required for the long life span of daf-2(e1370). scl-1 RNAi treatment reduced the life span of age-1(hx546) by about 80% (data not shown). Thus, scl-1 is required for the extension of life span of daf-2 and age-1 mutants and may generally function to extend life span of C. elegans.
Double mutant daf-2(e1370);scl-1(RNAi) has a lifespan of 19 days, while single mutant daf-2(e1370) has a lifespan of 26.5 days and wild type has a lifespan of 14.1 days.
Contains dependence
Ookuma S et al., 2003, Identification of a DAF-16 transcriptional target gene, scl-1, that regulates longevity and stress resistance in Caenorhabditis elegans. Curr Biol. 13(5):427-31 
12620193
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Insulin-like receptor subunit beta;Receptor protein-tyrosine kinase;hypothetical protein
Locus: CELE_Y55D5A.5
Wormbase description: daf-2 encodes a receptor tyrosine kinase that is the C. elegans insulin/IGF receptor ortholog; DAF-2 activity is required for a number of processes in C. elegans, including embryonic and larval development, formation of the developmentally arrested dauer larval stage (diapause), larval developmental timing, adult longevity, reproduction, fat storage, salt chemotaxis learning, and stress resistance, including response to high temperature, oxidative stress, and bacterial infection; DAF-2 signals through a conserved PI 3-kinase pathway to negatively regulate the activity of DAF-16, a Forkhead-related transcription factor, by inducing its phosphorylation and nuclear exclusion; in addition, DAF-2 negatively regulates the nuclear localization, and hence transcriptional activity, of SKN-1 in intestinal nuclei; amongst the 38 predicted insulin-like molecules in C. elegans, genetic and microarray analyses suggest that at least DAF-28, INS-1, and INS-7 are likely DAF-2 ligands; genetic mosaic and tissue-specific promoter studies indicate that daf-2 can function cell nonautonomously and within multiple cell types to influence dauer formation and adult lifespan, likely by regulating the production of secondary endocrine signals that coordinate growth and longevity throughout the animal; temporal analysis of daf-2 function indicates that daf-2 regulates lifespan, reproduction, and diapause independently, at distinct times during the animal's life cycle.
SCP-Like extracellular protein
Locus: CELE_F49E11.9
Wormbase description: scl-1 encodes a predicted secretory protein that is a member of the cysteine-rich secretory protein (CRISP) family; scl-1 activity positively regulates longevity and stress resistance; in wild-type animals, scl-1 mRNA is detected solely in eggs, while in daf-2 mutants it is detected in eggs and late adult stages; scl-1 expression appears to be under the control of the DAF-2/insulin-like signaling pathway as, in mixed-stage cultures, scl-1 mRNA levels are increased in daf-2 and age-1 mutants and undetectable in daf-16 mutants; scl-1 contains a DAF-16 consensus binding element within its predicted regulatory regions.
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| Drosophila melanogaster | InR |
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SynergyAge database hosts high-quality, manually curated information about the synergistic and antagonistic lifespan effects of genetic interventions in model organisms, also allowing users to explore the longevity relationships between genes in a visual way.
If you would like to cite this database please use:
Bunu, G., Toren, D., Ion, C. et al. SynergyAge, a curated database for synergistic and antagonistic interactions of longevity-associated genes. Sci Data 7, 366 (2020). https://doi.org/10.1038/s41597-020-00710-z
Group webpage: www.aging-research.group
