bir-2;daf-2;fem-1;fer-15

Lifespan changes: From wild type to bir-2;daf-2;fem-1;fer-15

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Genetic mutants with bir-2, daf-2, fem-1, fer-15 alterations

    Names of genes are ordered alphabetically. For the order of interventions, please see the specific paper.
  • Temperature °C

    20-25

  • Diet

    OP50

  • Lifespan (days)

    23.3

  • Lifespan comparisons

    Quadruple mutant bir-2(RNAi);daf-2(mu150);fem-23(hc17);fer-15(b26) has a lifespan of 23.3 days, while triple mutant daf-2(mu150);fem-23(hc17);fer-15(b26) has a lifespan of 28.8 days.

  • Citation
    View abstract

    Murphy CT et al., 2003, Genes that act downstream of DAF-16 to influence the lifespan of Caenorhabditis elegans. Nature. 424(6946):277-83 PubMed 12845331 Click here to select all mutants from this PubMed ID in the graph

Search genes: bir-2 daf-2 fem-1 fer-15 bir-2;daf-2;fem-1;fer-15
  • Entrez ID
  • Symbol
  • GenAge
  • Wormbase ID

Baculoviral IAP repeat-containing protein bir-2


Locus: CELE_C50B8.2


Wormbase description: The bir-2 gene encodes a protein with two BIR domains that may be involved in apoptosis.


  • Entrez ID
  • Symbol
  • GenAge
  • Wormbase ID

Insulin-like receptor subunit beta;Receptor protein-tyrosine kinase;hypothetical protein


Locus: CELE_Y55D5A.5


Wormbase description: daf-2 encodes a receptor tyrosine kinase that is the C. elegans insulin/IGF receptor ortholog; DAF-2 activity is required for a number of processes in C. elegans, including embryonic and larval development, formation of the developmentally arrested dauer larval stage (diapause), larval developmental timing, adult longevity, reproduction, fat storage, salt chemotaxis learning, and stress resistance, including response to high temperature, oxidative stress, and bacterial infection; DAF-2 signals through a conserved PI 3-kinase pathway to negatively regulate the activity of DAF-16, a Forkhead-related transcription factor, by inducing its phosphorylation and nuclear exclusion; in addition, DAF-2 negatively regulates the nuclear localization, and hence transcriptional activity, of SKN-1 in intestinal nuclei; amongst the 38 predicted insulin-like molecules in C. elegans, genetic and microarray analyses suggest that at least DAF-28, INS-1, and INS-7 are likely DAF-2 ligands; genetic mosaic and tissue-specific promoter studies indicate that daf-2 can function cell nonautonomously and within multiple cell types to influence dauer formation and adult lifespan, likely by regulating the production of secondary endocrine signals that coordinate growth and longevity throughout the animal; temporal analysis of daf-2 function indicates that daf-2 regulates lifespan, reproduction, and diapause independently, at distinct times during the animal's life cycle.


  • Entrez ID
  • Symbol
  • GenAge
  • Wormbase ID

Sex-determining protein fem-1


Locus: CELE_F35D6.1


Wormbase description: The fem-1 gene encodes an ankyrin repeat-containing protein orthologous to human FEM1A and is required for masculinization of germline and somatic tissues; FEM-1 is widely expressed and functions as a second messenger in the sex determination pathway, connecting the membrane protein TRA-2A to the transcription factor TRA-1A which it negatively regulates; FEM-1 may also play a role in apoptosis, as it is a substrate for the CED-3 protease and can induce apoptosis when overexpressed in mammalian cells.


  • Symbol
  • GenAge

No gene information for fer-15


Orthologs of bir-2;daf-2;fem-1;fer-15 in SynergyAge
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Orthologs of bir-2 in SynergyAge
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Species Gene
Orthologs of daf-2 in SynergyAge
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Species Gene
Drosophila melanogaster InR
Orthologs of fem-1 in SynergyAge
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Species Gene
Orthologs of fer-15 in SynergyAge
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Species Gene
About

SynergyAge database hosts high-quality, manually curated information about the synergistic and antagonistic lifespan effects of genetic interventions in model organisms, also allowing users to explore the longevity relationships between genes in a visual way.

Read more about SynergyAge database

How to cite us

If you would like to cite this database please use:

Bunu, G., Toren, D., Ion, C. et al. SynergyAge, a curated database for synergistic and antagonistic interactions of longevity-associated genes. Sci Data 7, 366 (2020). https://doi.org/10.1038/s41597-020-00710-z

Contact
Robi Tacutu, Ph.D.
Head: Systems Biology of Aging Group, Bioinformatics & Structural Biochemistry Department
Institute of Biochemistry, Ground floor
Splaiul Independentei 296, Bucharest, Romania
Email:

Group webpage: www.aging-research.group