Lifespan changes: From wild type to age-1;ife-2

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Genetic mutants with age-1, ife-2 alterations

    Names of genes are ordered alphabetically. For the order of interventions, please see the specific paper.
  • Temperature °C


  • Lifespan (days)


  • Lifespan change (compared to wild type)


  • Phenotype

    IFE-2 depletion further extends the lifespan of long-lived daf-2 and age-1 mutants

  • Lifespan comparisons

    Double mutant age-1(hx546);ife-2(RNAi) has a lifespan of 27.5 days, while single mutant age-1(hx546) has a lifespan of 22.8 days, single mutant ife-2(RNAi) has a lifespan of 22.4 days and wild type has a lifespan of 18.2 days.

  • Type of interaction
    See methods

    Synergistic (positive)

  • Citation
    View abstract

    Syntichaki P et al., 2007, eIF4E function in somatic cells modulates ageing in Caenorhabditis elegans. Nature. 445(7130):922-6 PubMed 17277769 Click here to select all mutants from this PubMed ID in the graph

Search genes: age-1 ife-2
  • Entrez ID
  • Symbol
  • GenAge
  • Wormbase ID

Phosphatidylinositol 3-kinase age-1;hypothetical protein

Locus: CELE_B0334.8

Wormbase description: age-1 encodes the C. elegans ortholog of the phosphoinositide 3-kinase (PI3K) p110 catalytic subunit; AGE-1, supplied maternally and embryonically, is a central component of the C. elegans insulin-like signaling pathway, lying downstream of the DAF-2/insulin receptor and upstream of both the PDK-1 and AKT-1/AKT-2 kinases and the DAF-16 forkhead type transcription factor, whose negative regulation is the key output of the insulin signaling pathway; in accordance with its role in insulin signaling, AGE-1 activity is required for regulation of metabolism, life span, dauer formation, stress resistance, salt chemotaxis learning, fertility, and embryonic development; although the age-1 expression pattern has not yet been reported, ectopic expression studies indicate that pan-neuronal age-1 expression is sufficient to rescue life-span defects, while neuronal, intestinal, or muscle expression can partially rescue dauer formation, and neuronal or muscle expression can rescue metabolic defects.

  • Entrez ID
  • Symbol
  • GenAge
  • Wormbase ID

Eukaryotic translation initiation factor 4E-2

Locus: CELE_R04A9.4

Wormbase description: ife-2 encodes a translation initiation factor 4F, cap-binding subunit (eIF-4E); by homology, IFE-2 is predicted to function in cap-dependent mRNA translation initiation; loss of ife-2 activity in adult animals extends lifespan.

Orthologs of age-1;ife-2 in SynergyAge
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Species Gene
Orthologs of age-1 in SynergyAge
Show in SynergyAge
Species Gene
Drosophila melanogaster Pi3K92E
Orthologs of ife-2 in SynergyAge
Show in SynergyAge
Species Gene

SynergyAge database hosts high-quality, manually curated information about the synergistic and antagonistic lifespan effects of genetic interventions in model organisms, also allowing users to explore the longevity relationships between genes in a visual way.

Read more about SynergyAge database

How to cite us

If you would like to cite this database please use:

Bunu, G., Toren, D., Ion, C. et al. SynergyAge, a curated database for synergistic and antagonistic interactions of longevity-associated genes. Sci Data 7, 366 (2020).

Robi Tacutu, Ph.D.
Head: Systems Biology of Aging Group, Bioinformatics & Structural Biochemistry Department
Institute of Biochemistry, Ground floor
Splaiul Independentei 296, Bucharest, Romania

Group webpage: